St18 Gene Detail

Summary

• Symbol
  St18
• Name
  suppression of tumorigenicity 18
• Synonyms
  mKIAA0535, Myt3, Nzf3

• Feature Type
  protein coding gene
• IDs
  MGI:2446700
  NCBI Gene: 240690
• Alliance
  gene page
• Transcription Start Sites
  42 TSS

Location &
Maps

• Sequence Map
  Chr1:6557455-6931164 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 1, 1.89 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  10238 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2446700	protein coding gene	Chr1:6557455-6931164 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0015820	protein coding gene	Chr1:3691040-4089826 (+)
A/J	MGP_AJ_G0015802	protein coding gene	Chr1:3637866-4023510 (+)
AKR/J	MGP_AKRJ_G0015761	protein coding gene	Chr1:3639265-4011548 (+)
BALB/cJ	MGP_BALBcJ_G0015758	protein coding gene	Chr1:3516876-3903971 (+)
C3H/HeJ	MGP_C3HHeJ_G0015592	protein coding gene	Chr1:3600147-3972343 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016210	protein coding gene	Chr1:3763176-4201077 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0013932	protein coding gene	Chr1:3118577-3457293 (+)
CAST/EiJ	MGP_CASTEiJ_G0015172	protein coding gene	Chr1:3770620-4160810 (+)
CBA/J	MGP_CBAJ_G0015565	protein coding gene	Chr1:3940494-4348487 (+)
DBA/2J	MGP_DBA2J_G0015664	protein coding gene	Chr1:3468254-3843115 (+)
FVB/NJ	MGP_FVBNJ_G0015669	protein coding gene	Chr1:3425317-3784257 (+)
LP/J	MGP_LPJ_G0015737	protein coding gene	Chr1:3773494-4158208 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015688	protein coding gene	Chr1:4209844-4615251 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016257	protein coding gene	Chr1:3584524-3960000 (+)
PWK/PhJ	MGP_PWKPhJ_G0014956	protein coding gene	Chr1:3363524-3727951 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0014736	protein coding gene	Chr1:3760783-4143249 (+)
WSB/EiJ	MGP_WSBEiJ_G0015236	protein coding gene	Chr1:3536298-3898254 (+)

Homology

• Human Ortholog
  ST18, ST18 C2H2C-type zinc finger transcription factor

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  ST18, ST18 C2H2C-type zinc finger transcription factor
  
• Synonyms
  NZF-3, NZF3, ZC2H2C3, ZC2HC10, ZNF387
• Links
  HGNC:18695

  NCBI Gene ID: 9705

  neXtProt AC: NX_O60284

  UniProt: O60284

  
  
• Chr Location
  8q11.23; chr8:52110838-52460959 (-)  GRCh38

---

• MGI Vertebrate Homology
  St18 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: ST18
• Gene Tree
  St18
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  20 phenotypes from 2 alleles in 3 genetic backgrounds
  1 phenotype from multigenic genotypes
  9 phenotype references
  

• All Mutations and Alleles
  8
• Endonuclease-mediated
  3
• Gene trapped
  1
• Targeted
  4
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  71 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype
• Recombinase Activity
  Comparison Matrix Gene Expression + Recombinase Activity

Myeloid-specific homozygous knockout causes hyperinflammation and results in increased susceptibility to polymicrobial sepsis, LPS-induced shock and DSS-induced colitis.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  25
• GO References
  6

Expression

• Assay Results
  826
• Tissues
  90
• cDNA Data
  24
• Literature Summary
  17

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase st18
  ZFIN st18

Sequences &
Gene Models

• All Sequences
  123
• RefSeq
  56
• UniProt
  8
• CCDS
  CCDS14810.1

• Ensembl
  ENSMUSG00000033740 (Evidence)
• NCBI Gene
  240690

Representative Sequences			Length	Strain/Species
genomic	240690	NCBI Gene Model | MGI Sequence Detail	373710	C57BL/6J
transcript	NM_001244692	RefSeq | MGI Sequence Detail	5913	C57BL/6
polypeptide	Q80TY4	UniProt | EBI | MGI Sequence Detail	1045	Not Applicable

Protein
Information

• UniProt
  8 Sequences
• Protein Ontology
  PR:000015679 suppression of tumorigenicity 18 protein
  (term hierarchy)
• InterPro Domains
  IPR013681 Myelin transcription factor 1
  IPR002515 Zinc finger, C2H2C-type
  IPR036060 Zinc finger, C2H2C-type superfamily
• GlyGen
  Q80TY4 1 site, 1 O-linked glycan (1 site)

Molecular
Reagents

• All nucleic 27

  cDNA 25

  Primer pair 2

  
  

  Microarray probesets 4

Other
Accession IDs

MGI:2138535

References

• Summaries
  All 54

  Developmental Gene Expression 17

  Gene Ontology 6

  Phenotypes 9
• Earliest
  J:83413 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Feb 28;10(1):35-48
• Latest
  J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for St18:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr5835	Chr1:6557531-6557562 (+)	92 bp
Tssr5836	Chr1:6557595-6557602 (+)	144 bp
Tssr5837	Chr1:6559399-6559424 (+)	1,957 bp
Tssr5838	Chr1:6559441-6559469 (+)	2,000 bp
Tssr5839	Chr1:6570594-6570621 (+)	13,153 bp
Tssr5840	Chr1:6578059-6578062 (+)	20,606 bp
Tssr5841	Chr1:6588728-6588740 (+)	31,279 bp
Tssr5842	Chr1:6588886-6588907 (+)	31,442 bp
Tssr5843	Chr1:6598036-6598084 (+)	40,605 bp
Tssr5844	Chr1:6598137-6598160 (+)	40,694 bp
Tssr5845	Chr1:6598178-6598211 (+)	40,740 bp
Tssr5846	Chr1:6598229-6598241 (+)	40,780 bp
Tssr5847	Chr1:6598316-6598332 (+)	40,869 bp
Tssr5848	Chr1:6598477-6598498 (+)	41,033 bp
Tssr5849	Chr1:6598500-6598534 (+)	41,062 bp
Tssr5850	Chr1:6607615-6607647 (+)	50,176 bp
Tssr5851	Chr1:6610012-6610029 (+)	52,566 bp
Tssr5852	Chr1:6615220-6615260 (+)	57,785 bp
Tssr5853	Chr1:6644393-6644417 (+)	86,950 bp
Tssr5854	Chr1:6646268-6646313 (+)	88,836 bp
Tssr5855	Chr1:6661839-6661847 (+)	104,388 bp
Tssr5856	Chr1:6667258-6667264 (+)	109,806 bp
Tssr5857	Chr1:6668724-6668728 (+)	111,271 bp
Tssr5858	Chr1:6669900-6669910 (+)	112,450 bp
Tssr5859	Chr1:6704629-6704640 (+)	147,180 bp
Tssr5860	Chr1:6706194-6706216 (+)	148,750 bp
Tssr5861	Chr1:6706221-6706238 (+)	148,775 bp
Tssr5862	Chr1:6708072-6708097 (+)	150,630 bp
Tssr5863	Chr1:6708313-6708348 (+)	150,876 bp
Tssr5864	Chr1:6736238-6736250 (+)	178,789 bp
Tssr5865	Chr1:6740538-6740545 (+)	183,087 bp
Tssr5866	Chr1:6742121-6742159 (+)	184,685 bp
Tssr5867	Chr1:6743599-6743604 (+)	186,147 bp
Tssr5868	Chr1:6744333-6744355 (+)	186,889 bp
Tssr5869	Chr1:6778085-6778102 (+)	220,639 bp
Tssr5870	Chr1:6800329-6800341 (+)	242,880 bp
Tssr5871	Chr1:6800348-6800358 (+)	242,898 bp
Tssr5872	Chr1:6800359-6800375 (+)	242,912 bp
Tssr5873	Chr1:6805051-6805098 (+)	247,620 bp
Tssr5874	Chr1:6805126-6805150 (+)	247,683 bp
Tssr5875	Chr1:6819461-6819462 (+)	262,007 bp
Tssr5876	Chr1:6912228-6912252 (+)	354,785 bp