Kif18a MGI Mouse Gene Detail - MGI:2446977

Symbol

Kif18a
Name

kinesin family member 18A
Synonyms

B130001M12Rik, gcd2, MGC:27627, N-8 kinesin

Feature Type

protein coding gene
IDs

MGI:2446977
NCBI Gene: 228421
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr2:109111165-109172094 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 56.55 cM
Mapping Data

4 experiments

SNPs within 2kb

1527 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2446977	protein coding gene	Chr2:109111083-109172094 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026239	protein coding gene	Chr2:111608365-111670072 (+)
A/J	MGP_AJ_G0026200	protein coding gene	Chr2:106926434-106987920 (+)
AKR/J	MGP_AKRJ_G0026180	protein coding gene	Chr2:109945554-110005765 (+)
BALB/cJ	MGP_BALBcJ_G0026209	protein coding gene	Chr2:107197093-107258200 (+)
C3H/HeJ	MGP_C3HHeJ_G0025959	protein coding gene	Chr2:110229511-110289656 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026660	protein coding gene	Chr2:115250223-115317673 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024046	protein coding gene	Chr2:102530975-102589309 (+)
CAST/EiJ	MGP_CASTEiJ_G0025424	protein coding gene	Chr2:110720725-110786543 (+)
CBA/J	MGP_CBAJ_G0025937	protein coding gene	Chr2:119246289-119310240 (+)
DBA/2J	MGP_DBA2J_G0026075	protein coding gene	Chr2:106437832-106499796 (+)
FVB/NJ	MGP_FVBNJ_G0026038	protein coding gene	Chr2:105364356-105424233 (+)
LP/J	MGP_LPJ_G0026178	protein coding gene	Chr2:111782794-111845380 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026062	protein coding gene	Chr2:123352036-123424213 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026714	protein coding gene	Chr2:110084787-110148221 (+)
PWK/PhJ	MGP_PWKPhJ_G0025159	protein coding gene	Chr2:106074743-106137262 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024959	protein coding gene	Chr2:109315266-109371963 (+)
WSB/EiJ	MGP_WSBEiJ_G0025491	protein coding gene	Chr2:110847728-110913253 (+)

Human Ortholog

KIF18A, kinesin family member 18A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KIF18A, kinesin family member 18A
Synonyms

MS-KIF18A, PPP1R99
Links

HGNC:29441

NCBI Gene ID: 81930

neXtProt AC: NX_Q8NI77

UniProt: Q8NI77
Chr Location

11p14.1; chr11:28020619-28108156 (-) GRCh38

MGI Vertebrate Homology

Kif18a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: KIF18A
Gene Tree

Kif18a

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Phenotype Summary

33 phenotypes from 2 alleles in 5 genetic backgrounds
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

43
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

33
Radiation induced

2
Targeted

5
Genomic Mutations

3 involving Kif18a
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

63 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for loss of function alleles exhibit reduced female fertility and male infertility due to primordial germ cell depletion. The sterility phenotype is incompletely penetrant, has variable expressivity, and is modulated by strain background.

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All GO Annotations

47
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

764
Tissues

37
cDNA Data

59
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA KIF18A

Xenbase kif18a

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All Sequences

55
RefSeq

10
UniProt

4
CCDS

CCDS16507.1

Ensembl

ENSMUSG00000027115 (Evidence)
NCBI Gene

228421

			Length	Strain/Species	Flank
genomic	228421	NCBI Gene Model \| MGI Sequence Detail	60930	C57BL/6J	± kb
transcript	NM_139303	RefSeq \| MGI Sequence Detail	3289	C57BL/6
polypeptide	Q91WD7	UniProt \| EBI \| MGI Sequence Detail	886	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000009292 kinesin-like protein KIF18A

(term hierarchy)
InterPro Domains

IPR027640 Kinesin-like protein

IPR001752 Kinesin motor domain

IPR019821 Kinesin motor domain, conserved site

IPR036961 Kinesin motor domain superfamily

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 63

cDNA 59

Primer pair 3

Other 1

Microarray probesets 3

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MGI:2139208, MGI:2444495, MGI:3050505

Summaries

All 52

Developmental Gene Expression 4

Gene Ontology 8

Phenotypes 20
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:352185 Mihajlovic AI, et al., Spindle assembly checkpoint insensitivity allows meiosis-II despite chromosomal defects in aged eggs. EMBO Rep. 2023 Nov 6;24(11):e57227

TSS for Kif18a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr19299	Chr2:109111126-109111143 (+)	-30 bp
Tssr19300	Chr2:109111154-109111208 (+)	16 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24