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Tenm4 Gene Detail
Summary
  • Symbol
    Tenm4
  • Name
    teneurin transmembrane protein 4
  • Synonyms
    Doc4, ELM2, l(7)-3Rn, l7Rn3, mKIAA1302, Odz4, Ten-m4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2447063
    NCBI Gene: 23966
  • Alliance
    gene page
  • Transcription Start Sites
    31 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:95820453-96560300 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 52.53 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    18762 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2447063
 protein coding gene Chr7:95550262-96560300 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032517
 protein coding gene Chr7:98840716-99603367 (+)
A/J MGP_AJ_G0032491
 protein coding gene Chr7:96392520-97132173 (+)
AKR/J MGP_AKRJ_G0032427
 protein coding gene Chr7:98667453-99429336 (+)
BALB/cJ MGP_BALBcJ_G0032502
 protein coding gene Chr7:96080788-96823016 (+)
C3H/HeJ MGP_C3HHeJ_G0032217
 protein coding gene Chr7:99050105-99806569 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033000
 protein coding gene Chr7:102692196-103463730 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029995
 protein coding gene Chr7:98885862-99615742 (+)
CAST/EiJ MGP_CASTEiJ_G0031544
 protein coding gene Chr7:90554283-91316008 (+)
CBA/J MGP_CBAJ_G0032184
 protein coding gene Chr7:106171015-106964376 (+)
DBA/2J MGP_DBA2J_G0032336
 protein coding gene Chr7:94765554-95502330 (+)
FVB/NJ MGP_FVBNJ_G0032292
 protein coding gene Chr7:94542954-95285001 (+)
LP/J MGP_LPJ_G0032425
 protein coding gene Chr7:100141495-100917828 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032325
 protein coding gene Chr7:107769314-108533544 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033022
 protein coding gene Chr7:98004608-98750348 (+)
PWK/PhJ MGP_PWKPhJ_G0031262
 protein coding gene Chr7:87813086-88558586 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031105
 protein coding gene Chr7:85243265-85991808 (+)
WSB/EiJ MGP_WSBEiJ_G0031661
 protein coding gene Chr7:98632819-99386883 (+)



Homology
more
  • Human Ortholog
    TENM4, teneurin transmembrane protein 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TENM4, teneurin transmembrane protein 4
  • Synonyms
    Doc4, ETM5, ODZ4, ten-4, TEN4, Ten-M4, TNM4
  • Links
    NCBI Gene ID: 26011
    neXtProt AC: NX_Q6N022
    UniProt: Q6N022

  • Chr Location
    11q14.1; chr11:78652829-79441030 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TENM4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 7 alleles in 7 genetic backgrounds
    18 phenotypes from multigenic genotypes
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Various ENU-induced alleles cause prenatal lethality associated with impaired mesoderm development and lead to pleiotropic phenotypes. The most severe alleles cause failure of gastrulation and somitogenesis while the least severe one allows survival to adulthood with runting of variable penetrance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    902
  • Tissues
    109
  • cDNA Data
    17
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000048078 Ensembl Gene Model | MGI Sequence Detail 739848 C57BL/6J ±  kb
    transcript ENSMUST00000107165 Ensembl | MGI Sequence Detail 10930 Not Applicable  
    polypeptide ENSMUSP00000102783 Ensembl | MGI Sequence Detail 2833 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 18
      Primer pair 5
      Other 5

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-11691, MGD-MRK-11723, MGI:2142385, MGI:96735
    References
    more
    • Summaries
      All 90
      Developmental Gene Expression 15
      Gene Ontology 10
      Phenotypes 45
    • Earliest
      J:141526 Russell LB, et al., Analysis of the albino-locus region of the mouse. III. Time of death of prenatal lethals. Genetics. 1979 May;92(1):205-13
    • Latest
      J:353379 Kurihara Y, et al., Nogo Receptor Antagonist LOTUS Promotes Neurite Outgrowth through Its Interaction with Teneurin-4. Cells. 2024 Aug 17;13(16)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory