Phospho1 MGI Mouse Gene Detail - MGI:2447348

Symbol

Phospho1
Name

phosphatase, orphan 1
Synonyms

D11Moh36

Feature Type

protein coding gene
IDs

MGI:2447348
NCBI Gene: 237928
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr11:95715326-95722966 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 59.01 cM
Mapping Data

3 experiments

SNPs within 2kb

244 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2447348	protein coding gene	Chr11:95715325-95722966 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018989	protein coding gene	Chr11:98060948-98071097 (+)
A/J	MGP_AJ_G0018957	protein coding gene	Chr11:94094610-94101844 (+)
AKR/J	MGP_AKRJ_G0018927	protein coding gene	Chr11:96997027-97004345 (+)
BALB/cJ	MGP_BALBcJ_G0018930	protein coding gene	Chr11:94573778-94582120 (+)
C3H/HeJ	MGP_C3HHeJ_G0018744	protein coding gene	Chr11:97129220-97136501 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019382	protein coding gene	Chr11:101110674-101113847 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017012	protein coding gene	Chr11:91570262-91577517 (+)
CAST/EiJ	MGP_CASTEiJ_G0018298	protein coding gene	Chr11:97944113-97952525 (+)
CBA/J	MGP_CBAJ_G0018715	protein coding gene	Chr11:105263841-105274444 (+)
DBA/2J	MGP_DBA2J_G0018823	protein coding gene	Chr11:93668048-93675784 (+)
FVB/NJ	MGP_FVBNJ_G0018812	protein coding gene	Chr11:93140465-93148598 (+)
LP/J	MGP_LPJ_G0018893	protein coding gene	Chr11:98625648-98634750 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018839	protein coding gene	Chr11:105286816-105295264 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019422	protein coding gene	Chr11:97286857-97294366 (+)
PWK/PhJ	MGP_PWKPhJ_G0018069	protein coding gene	Chr11:94608544-94616520 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017858	protein coding gene	Chr11:96982220-96989326 (+)
WSB/EiJ	MGP_WSBEiJ_G0018347	protein coding gene	Chr11:97196382-97204558 (+)

Human Ortholog

PHOSPHO1, phosphoethanolamine/phosphocholine phosphatase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PHOSPHO1, phosphoethanolamine/phosphocholine phosphatase 1
Links

HGNC:16815

NCBI Gene ID: 162466

neXtProt AC: NX_Q8TCT1

UniProt: Q8TCT1
Chr Location

17q21.32; chr17:49223366-49230787 (-) GRCh38

MGI Vertebrate Homology

Phospho1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PHOSPHO1
Protein SuperFamily

PyrdxlP_Pase_PHOSPHO2
Gene Tree

Phospho1

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Phenotype Summary

32 phenotypes from 1 allele in 1 genetic background
8 phenotypes from multigenic genotypes
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (ENU)

1
Targeted

4
Genomic Mutations

2 involving Phospho1
Incidental Mutations

APF
Find Mice (IMSR)

10 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for an ENU-induced mutation exhibit fractures, bowed long bones, osteomalacia, and scoliosis.

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All GO Annotations

17
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

980
Tissues

133
cDNA Data

10
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA PHOSPHO1

Xenbase phospho1

ZFIN phospho1

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All Sequences

35
RefSeq

2
UniProt

3
CCDS

CCDS36288.1

Ensembl

ENSMUSG00000050860 (Evidence)
NCBI Gene

237928

			Length	Strain/Species	Flank
genomic	237928	NCBI Gene Model \| MGI Sequence Detail	7641	C57BL/6J	± kb
transcript	NM_153104	RefSeq \| MGI Sequence Detail	1910	ZRU/MplStud
polypeptide	Q8R2H9	UniProt \| EBI \| MGI Sequence Detail	267	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000012669 phosphoethanolamine/phosphocholine phosphatase

(term hierarchy)
EC

3.1.3.75
InterPro Domains

IPR006384 HAD hydrolase, subfamily IA, Pyridoxal phosphate phosphatase-like

IPR036412 HAD-like superfamily

IPR023214 HAD superfamily

IPR016965 Phosphatase PHOSPHO-type

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All nucleic 19

Genomic 7

cDNA 10

Primer pair 2

Microarray probesets 2

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MGI:1343159

Summaries

All 48

Developmental Gene Expression 5

Gene Ontology 11

Phenotypes 19
Earliest

J:51104 Mohlke KL, et al., Comparative mapping of distal murine chromosome 11 and human 17q21.3 in a region containing a modifying locus for murine plasma von Willebrand factor level. Genomics. 1998 Nov 15;54(1):19-30
Latest

J:295906 Jiang M, et al., Phosphocholine accumulation and PHOSPHO1 depletion promote adipose tissue thermogenesis. Proc Natl Acad Sci U S A. 2020 Jun 30;117(26):15055-15065

TSS for Phospho1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr104388	Chr11:95715295-95715338 (+)	-9 bp
Tssr104389	Chr11:95715339-95715375 (+)	31 bp
Tssr104390	Chr11:95715404-95715419 (+)	86 bp
Tssr104391	Chr11:95715961-95715975 (+)	642 bp
Tssr104392	Chr11:95715985-95716005 (+)	669 bp
Tssr104393	Chr11:95716047-95716066 (+)	731 bp
Tssr3654	Chr11:95721348-95721370 (+)	6,033 bp
Tssr104394	Chr11:95721579-95721594 (+)	6,261 bp
Tssr104395	Chr11:95722150-95722163 (+)	6,831 bp
Tssr104396	Chr11:95722187-95722199 (+)	6,867 bp
Tssr104397	Chr11:95722350-95722364 (+)	7,031 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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