Als2cl MGI Mouse Gene Detail - MGI:2447532

Symbol

Als2cl
Name

ALS2 C-terminal like
Synonyms

D930044G19Rik, mRn.49018

Feature Type

protein coding gene
IDs

MGI:2447532
NCBI Gene: 235633
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr9:110709203-110729598 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 60.79 cM
Mapping Data

3 experiments

SNPs within 2kb

639 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2447532	protein coding gene	Chr9:110708938-110729598 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035363	protein coding gene	Chr9:113071446-113092114 (+)
A/J	MGP_AJ_G0035344	protein coding gene	Chr9:108943920-108964588 (+)
AKR/J	MGP_AKRJ_G0035275	protein coding gene	Chr9:111651660-111672328 (+)
BALB/cJ	MGP_BALBcJ_G0035339	protein coding gene	Chr9:108704320-108725725 (+)
C3H/HeJ	MGP_C3HHeJ_G0035047	protein coding gene	Chr9:112161218-112183308 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035861	protein coding gene	Chr9:116168446-116190354 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032747	protein coding gene	Chr9:106163409-106184179 (+)
CAST/EiJ	MGP_CASTEiJ_G0034353	protein coding gene	Chr9:111954079-111979306 (+)
CBA/J	MGP_CBAJ_G0035014	protein coding gene	Chr9:120466515-120493585 (+)
DBA/2J	MGP_DBA2J_G0035173	protein coding gene	Chr9:108406287-108426955 (+)
FVB/NJ	MGP_FVBNJ_G0035120	protein coding gene	Chr9:107245100-107265771 (+)
LP/J	MGP_LPJ_G0035252	protein coding gene	Chr9:113360519-113381197 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035160	protein coding gene	Chr9:121782539-121803205 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035881	protein coding gene	Chr9:112001073-112022344 (+)
PWK/PhJ	MGP_PWKPhJ_G0034060	protein coding gene	Chr9:108655358-108676594 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033895	protein coding gene	Chr9:112080909-112104311 (+)
WSB/EiJ	MGP_WSBEiJ_G0034474	protein coding gene	Chr9:111870993-111893069 (+)

Human Ortholog

ALS2CL, ALS2 C-terminal like

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ALS2CL, ALS2 C-terminal like
Synonyms

RN49018
Links

HGNC:20605

NCBI Gene ID: 259173

neXtProt AC: NX_Q60I27

UniProt: Q60I27
Chr Location

3p21.31

MGI Vertebrate Homology

Als2cl stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ALS2CL
Gene Tree

Als2cl

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
24 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

2
Gene trapped

5
Spontaneous

2
Targeted

2
Genomic Mutations

2 involving Als2cl
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

53 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

13
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

42
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase als2cl

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All Sequences

77
RefSeq

27
UniProt

3
CCDS

CCDS23579.1

Ensembl

ENSMUSG00000044037 (Evidence)
NCBI Gene

235633

			Length	Strain/Species	Flank
genomic	235633	NCBI Gene Model \| MGI Sequence Detail	20396	C57BL/6J	± kb
transcript	NM_001146060	RefSeq \| MGI Sequence Detail	5186	ZRU/MplStud
polypeptide	Q60I26	UniProt \| EBI \| MGI Sequence Detail	952	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000003972 ALS2 C-terminal-like protein

(term hierarchy)
InterPro Domains

IPR051984 Alsin GEFs and Motor Neuron Regulators

IPR035899 Dbl homology (DH) domain superfamily

IPR003409 MORN repeat

IPR003123 VPS9 domain

IPR037191 VPS9 domain superfamily

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All nucleic 42

cDNA 42

Microarray probesets 3

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MGI:2442331

Summaries

All 50

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 24
Earliest

J:13132 DEOL MS, et al., The spinner mouse. J Hered. 1962 May-Jun;53:133-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Als2cl:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr87427	Chr9:110709225-110709255 (+)	37 bp
Tssr87428	Chr9:110709260-110709275 (+)	65 bp
Tssr87429	Chr9:110709317-110709332 (+)	122 bp
Tssr87430	Chr9:110709354-110709383 (+)	166 bp
Tssr87431	Chr9:110709389-110709414 (+)	199 bp
Tssr87432	Chr9:110709418-110709432 (+)	222 bp
Tssr87433	Chr9:110709469-110709478 (+)	271 bp
Tssr87434	Chr9:110724809-110724818 (+)	15,611 bp
Tssr87435	Chr9:110724838-110724849 (+)	15,641 bp
Tssr87436	Chr9:110726016-110726047 (+)	16,829 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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