About   Help   FAQ
Klk15 Gene Detail
Summary
  • Symbol
    Klk15
  • Name
    kallikrein related-peptidase 15
  • Feature Type
    protein coding gene
  • IDs
    MGI:2447533
    NCBI Gene: 317652
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr7:43583164-43589063 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 28.41 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    331 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2447533
 protein coding gene Chr7:43578829-43589459 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032148
 protein coding gene Chr7:43986095-43991956 (+)
A/J MGP_AJ_G0032133
 protein coding gene Chr7:43065628-43071368 (+)
AKR/J MGP_AKRJ_G0032063
 protein coding gene Chr7:44459818-44465708 (+)
BALB/cJ MGP_BALBcJ_G0032138
 protein coding gene Chr7:43186332-43192513 (+)
C3H/HeJ MGP_C3HHeJ_G0031854
 protein coding gene Chr7:44959910-44966594 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032622
 protein coding gene Chr7:46212246-46219016 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029645
 protein coding gene Chr7:45194650-45837093 (+)
CAST/EiJ MGP_CASTEiJ_G0031184
 protein coding gene Chr7:36156664-36165670 (+)
CBA/J MGP_CBAJ_G0031823
 protein coding gene Chr7:47671244-47677628 (+)
DBA/2J MGP_DBA2J_G0031972
 protein coding gene Chr7:42872381-42878649 (+)
FVB/NJ MGP_FVBNJ_G0031933
 protein coding gene Chr7:42583501-42589400 (+)
LP/J MGP_LPJ_G0032051
 protein coding gene Chr7:44727673-44734959 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031969
 protein coding gene Chr7:46591332-46597217 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032642
 protein coding gene Chr7:43581478-43587390 (+)
PWK/PhJ MGP_PWKPhJ_G0030905
 protein coding gene Chr7:36332864-36338813 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030744
 protein coding gene Chr7:31619973-31625918 (+)
WSB/EiJ MGP_WSBEiJ_G0031298
 protein coding gene Chr7:44141053-44146951 (+)



Homology
more
  • Human Ortholog
    KLK15, kallikrein related peptidase 15
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KLK15, kallikrein related peptidase 15
  • Synonyms
    ACO, HSRNASPH
  • Links
    NCBI Gene ID: 55554
    neXtProt AC: NX_Q9H2R5
    UniProt: Q9H2R5

  • Chr Location
    19q13.33; chr19:50825289-50837213 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    4
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000055193 Ensembl Gene Model | MGI Sequence Detail 5900 C57BL/6J ±  kb
    transcript ENSMUST00000068625 Ensembl | MGI Sequence Detail 845 Not Applicable  
    polypeptide ENSMUSP00000066969 Ensembl | MGI Sequence Detail 254 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR001314 Peptidase S1A, chymotrypsin family
      IPR009003 Peptidase S1, PA clan
      IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold
      IPR001254 Serine proteases, trypsin domain
      IPR018114 Serine proteases, trypsin family, histidine active site
      IPR033116 Serine proteases, trypsin family, serine active site
    Molecular
    Reagents
    less
    • All nucleic 4
      cDNA 4

      Microarray probesets 1
    References
    more
    • Summaries
      All 21
      Developmental Gene Expression 1
      Gene Ontology 1
      Phenotypes 8
    • Earliest
      J:80454 Olsson AY, et al., Organization and evolution of the glandular kallikrein locus in Mus musculus. Biochem Biophys Res Commun. 2002 Nov 29;299(2):305-11
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory