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Serac1 Gene Detail
Summary
  • Symbol
    Serac1
  • Name
    serine active site containing 1
  • Synonyms
    4930511N22Rik, D17Ertd141e
  • Feature Type
    protein coding gene
  • IDs
    MGI:2447813
    NCBI Gene: 321007
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:6092471-6130016 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 3.67 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1031 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2447813
 protein coding gene Chr17:6090846-6130064 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023109
 protein coding gene Chr17:3201946-3240920 (-)
A/J MGP_AJ_G0023079
 protein coding gene Chr17:3128602-3167285 (-)
AKR/J MGP_AKRJ_G0023045
 protein coding gene Chr17:3202008-3244299 (-)
BALB/cJ MGP_BALBcJ_G0023082
 protein coding gene Chr17:3098369-3135806 (-)
C3H/HeJ MGP_C3HHeJ_G0022842
 protein coding gene Chr17:3239660-3277056 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023527
 protein coding gene Chr17:3364548-3404938 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021027
 protein coding gene Chr17:2910330-2948141 (-)
CAST/EiJ MGP_CASTEiJ_G0022360
 protein coding gene Chr17:3237746-3277326 (-)
CBA/J MGP_CBAJ_G0022809
 protein coding gene Chr17:3538260-3575492 (-)
DBA/2J MGP_DBA2J_G0022944
 protein coding gene Chr17:2986086-3023398 (-)
FVB/NJ MGP_FVBNJ_G0022917
 protein coding gene Chr17:3019715-3057268 (-)
LP/J MGP_LPJ_G0023012
 protein coding gene Chr17:3342234-3379522 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022938
 protein coding gene Chr17:3352742-3392725 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023546
 protein coding gene Chr17:3229787-3268754 (-)
PWK/PhJ MGP_PWKPhJ_G0022104
 protein coding gene Chr17:3057157-3095472 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021932
 protein coding gene Chr17:3171267-3209044 (-)
WSB/EiJ MGP_WSBEiJ_G0022410
 protein coding gene Chr17:3200311-3240804 (-)



Homology
more
  • Human Ortholog
    SERAC1, serine active site containing 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SERAC1, serine active site containing 1
  • Links
    NCBI Gene ID: 84947
    neXtProt AC: NX_Q96JX3
    UniProt: Q96JX3

  • Chr Location
    6q25.3; chr6:158109519-158168280 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Serac1 mouse models; 1 with human SERAC1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    7 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 2 alleles in 2 genetic backgrounds
    361 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit 3-methylgutaconic aciduria, deafness, dystonia, hepatopathy including impaired mitochondrial oxidative phosphorylation, encephalopathy, Leigh-like syndrome and cardiomyopathy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    28
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000015659 Ensembl Gene Model | MGI Sequence Detail 37546 C57BL/6J ±  kb
    transcript ENSMUST00000097432 Ensembl | MGI Sequence Detail 4007 Not Applicable  
    polypeptide ENSMUSP00000095043 Ensembl | MGI Sequence Detail 654 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      cDNA 28
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1098532
    References
    more
    • Summaries
      All 387
      Diseases 7
      Gene Ontology 5
      Phenotypes 361
    • Earliest
      J:30229 Davisson MT, et al., Segmental trisomy as a mouse model for Down syndrome. Prog Clin Biol Res. 1993;384:117-33
    • Latest
      J:354984 Emili M, et al., Reversal of neurodevelopmental impairment and cognitive enhancement by pharmacological intervention with the polyphenol polydatin in a Down syndrome model. Neuropharmacology. 2024 Sep 27;261:110170
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory