H2bc12 MGI Mouse Gene Detail - MGI:2448399

Symbol

H2bc12
Name

H2B clustered histone 12
Synonyms

Hist1h2bk

Feature Type

protein coding gene
IDs

MGI:2448399
NCBI Gene: 319184
Member of

Hist1 cluster
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr13:22220040-22220515 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 8.14 cM, cytoband A2-A3
Mapping Data

1 experiment

SNPs within 2kb

174 from dbSNP Build 142
Strain Annotations

8

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2448399	protein coding gene	Chr13:22219991-22220515 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020307	protein coding gene	Chr13:19356544-19356894 (+)
A/J	MGP_AJ_G0020266	protein coding gene	Chr13:18910230-18910732 (+)
AKR/J	no annotation
BALB/cJ	MGP_BALBcJ_G0020253	protein coding gene	Chr13:18960706-18961508 (+)
C3H/HeJ	no annotation
C57BL/6NJ	MGP_C57BL6NJ_G0020692	protein coding gene	Chr13:20036396-20037646 (+)
CAROLI/EiJ	no annotation
CAST/EiJ	no annotation
CBA/J	no annotation
DBA/2J	no annotation
FVB/NJ	MGP_FVBNJ_G0020125	protein coding gene	Chr13:18203940-18204268 (+)
LP/J	MGP_LPJ_G0020211	protein coding gene	Chr13:19585188-19585898 (+)
NOD/ShiLtJ	no annotation
NZO/HlLtJ	MGP_NZOHlLtJ_G0020724	protein coding gene	Chr13:19040322-19040711 (+)
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Human Ortholog

H2BC12, H2B clustered histone 12

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

H2BC12, H2B clustered histone 12
Synonyms

H2BFAiii, H2BFT, H2BK, H2B/S, HIST1H2BK
Links

HGNC:13954

NCBI Gene ID: 85236

neXtProt AC: NX_O60814

UniProt: O60814
Chr Location

6p22.1; chr6:27138293-27146858 (-) GRCh38

MGI Vertebrate Homology

H2bc12 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: H2BC12
Gene Tree

H2bc12

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Phenotype Summary

8 phenotype references

All Mutations and Alleles

2
Chemically induced (other)

1
Radiation induced

1
Genomic Mutations

2 involving H2bc12
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

7 strains or lines available

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All GO Annotations

14
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

2

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase h2bc12

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All Sequences

20
RefSeq

2
UniProt

2
CCDS

CCDS26305.1

Ensembl

ENSMUSG00000062727 (Evidence)
NCBI Gene

319184

			Length	Strain/Species	Flank
genomic	ENSMUSG00000062727	Ensembl Gene Model \| MGI Sequence Detail	476	C57BL/6J	± kb
transcript	ENSMUST00000110455	Ensembl \| MGI Sequence Detail	476	Not Applicable
polypeptide	ENSMUSP00000106085	Ensembl \| MGI Sequence Detail	126	Not Applicable

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UniProt

2 Sequences
InterPro Domains

IPR009072 Histone-fold

IPR007125 Histone H2A/H2B/H3

IPR000558 Histone H2B
GlyGen

Q8CGP1 2 sites, 1 O-linked glycan (1 site)

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All nucleic 3

Genomic 1

cDNA 2

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MGI:6324993

Summaries

All 21

Gene Ontology 3

Phenotypes 8
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:141688 Goldsworthy M, et al., Role of the transcription factor sox4 in insulin secretion and impaired glucose tolerance. Diabetes. 2008 Aug;57(8):2234-44

TSS for H2bc12:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr118816	Chr13:22219999-22220018 (+)	-31 bp
Tssr118817	Chr13:22220040-22220044 (+)	2 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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