H4c8 Gene Detail

Summary

• Symbol
  H4c8
• Name
  H4 clustered histone 8
• Synonyms
  Hist1h4h

• Feature Type
  protein coding gene
• IDs
  MGI:2448427
  NCBI Gene: 69386
• Member of
  Hist1 cluster
• Alliance
  gene page
• Transcription Start Sites
  1 TSS

Location &
Maps

• Sequence Map
  Chr13:23715214-23715648 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 13, 9.77 cM, cytoband A2-A3
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  74 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2448427	protein coding gene	Chr13:23715214-23715689 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020344	protein coding gene	Chr13:20942323-20942795 (+)
A/J	MGP_AJ_G0020301	protein coding gene	Chr13:20569064-20569854 (+)
AKR/J	MGP_AKRJ_G0020273	protein coding gene	Chr13:20811900-20812372 (+)
BALB/cJ	MGP_BALBcJ_G0020287	protein coding gene	Chr13:20558430-20558902 (+)
C3H/HeJ	MGP_C3HHeJ_G0020096	protein coding gene	Chr13:20894183-20894655 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020732	protein coding gene	Chr13:21707669-21708141 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018316	protein coding gene	Chr13:19372753-19373225 (+)
CAST/EiJ	MGP_CASTEiJ_G0019618	protein coding gene	Chr13:20581249-20581721 (+)
CBA/J	MGP_CBAJ_G0020047	protein coding gene	Chr13:22549119-22549591 (+)
DBA/2J	MGP_DBA2J_G0020173	protein coding gene	Chr13:20109633-20110105 (+)
FVB/NJ	MGP_FVBNJ_G0020161	protein coding gene	Chr13:19756916-19757446 (+)
LP/J	MGP_LPJ_G0020246	protein coding gene	Chr13:21269178-21270075 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020191	protein coding gene	Chr13:22862530-22864307 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020762	protein coding gene	Chr13:20667733-20669155 (+)
PWK/PhJ	MGP_PWKPhJ_G0019374	protein coding gene	Chr13:20138552-20139290 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019184	protein coding gene	Chr13:19466262-19479489 (+)
WSB/EiJ	MGP_WSBEiJ_G0019674	protein coding gene	Chr13:20796244-20796716 (+)

Homology

• Human Ortholog
  H4C5, H4 clustered histone 5

• Vertebrate Orthologs
  16

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  H4C5, H4 clustered histone 5
  
• Synonyms
  H4-16, H4C1, H4C11, H4C12, H4C13, H4C14, H4C15, H4C16, H4C2, H4C3, H4C4, H4C6, H4C8, H4C9, H4FJ, H4/j, HIST1H4E, TEBIVANED3, TEVANED3
• Links
  HGNC:4790

  NCBI Gene ID: 8367

  neXtProt AC: NX_P62805

  UniProt: P62805

  
  
• Chr Location
  6p22.2; chr6:26204610-26205021 (+)  GRCh38

---

• Human Ortholog
  H4C9, H4 clustered histone 9
  
• Synonyms
  H4-16, H4C1, H4C11, H4C12, H4C13, H4C14, H4C15, H4C16, H4C2, H4C3, H4C4, H4C5, H4C6, H4C8, H4FM, H4/m, H4M, HIST1H4I, TEBIVANED4, TEVANED4
• Links
  HGNC:4793

  NCBI Gene ID: 8294

  neXtProt AC: NX_P62805

  UniProt: P62805

  
  
• Chr Location
  6p22.1; chr6:27139282-27139678 (+)  GRCh38

---

• MGI Vertebrate Homology
  H4c8 stringent orthology
  2 human;1 mouse;4 rat;10 zebrafish
  
• HCOP
  vertebrate homology predictions: H4C5, H4C9
• Gene Tree
  H4c8
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  8 phenotype references
  

• All Mutations and Alleles
  2
• Chemically induced (other)
  1
• Radiation induced
  1
• Genomic Mutations
  2 involving H4c8
• Incidental Mutations
  APF
• Find Mice (IMSR)
  1 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  4
• GO References
  1

Expression

• Assay Results
  738
• Tissues
  24
• cDNA Data
  7
• Literature Summary
  2

Images

Tissue x Stage Matrix

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  33
• RefSeq
  2
• UniProt
  1
• CCDS
  CCDS26340.1

• Ensembl
  ENSMUSG00000060981 (Evidence)
• NCBI Gene
  69386

Representative Sequences			Length	Strain/Species
genomic	69386	NCBI Gene Model | MGI Sequence Detail	435	C57BL/6J
transcript	NM_153173	RefSeq | MGI Sequence Detail	435	C57BL/6
polypeptide	P62806	UniProt | EBI | MGI Sequence Detail	103	Not Applicable

Protein
Information

• UniProt
  1 Sequence

Molecular
Reagents

• All nucleic 9

  Genomic 1

  cDNA 7

  Primer pair 1

  
  

  Microarray probesets 3

Other
Accession IDs

MGI:1916636, MGI:6324989

References

• Summaries
  All 31

  Developmental Gene Expression 2

  Gene Ontology 1

  Phenotypes 8
• Earliest
  J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
• Latest
  J:177918 Quille ML, et al., High-throughput analysis of promoter occupancy reveals new targets for Arx, a gene mutated in mental retardation and interneuronopathies. PLoS One. 2011;6(9):e25181

TSS for H4c8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr118826	Chr13:23715253-23715258 (+)	42 bp