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Mgst2 Gene Detail
Summary
  • Symbol
    Mgst2
  • Name
    microsomal glutathione S-transferase 2
  • Synonyms
    GST2, MGC:41409, MGST-II
  • Feature Type
    protein coding gene
  • IDs
    MGI:2448481
    NCBI Gene: 211666
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:51567781-51590098 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 22.52 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    907 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2448481
 protein coding gene Chr3:51544179-51590098 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027200
 protein coding gene Chr3:50140884-50166267 (+)
A/J MGP_AJ_G0027160
 protein coding gene Chr3:48675985-48698757 (+)
AKR/J MGP_AKRJ_G0027129
 protein coding gene Chr3:49643979-49666302 (+)
BALB/cJ MGP_BALBcJ_G0027172
 protein coding gene Chr3:48536324-48558623 (+)
C3H/HeJ MGP_C3HHeJ_G0026915
 protein coding gene Chr3:49869469-49894617 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027618
 protein coding gene Chr3:52158750-52188345 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024978
 protein coding gene Chr3:45301370-45326289 (+)
CAST/EiJ MGP_CASTEiJ_G0026368
 protein coding gene Chr3:49938351-49959413 (+)
CBA/J MGP_CBAJ_G0026892
 protein coding gene Chr3:53783712-53808986 (+)
DBA/2J MGP_DBA2J_G0027026
 protein coding gene Chr3:48281129-48303343 (+)
FVB/NJ MGP_FVBNJ_G0026994
 protein coding gene Chr3:47262397-47285022 (+)
LP/J MGP_LPJ_G0027138
 protein coding gene Chr3:50897356-50922480 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027012
 protein coding gene Chr3:57968219-57991471 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027677
 protein coding gene Chr3:49571066-49593336 (+)
PWK/PhJ MGP_PWKPhJ_G0026100
 protein coding gene Chr3:47934354-47956414 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025913
 protein coding gene Chr3:49225468-49247445 (+)
WSB/EiJ MGP_WSBEiJ_G0026442
 protein coding gene Chr3:49675023-49700138 (+)



Homology
more
  • Human Ortholog
    MGST2, microsomal glutathione S-transferase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MGST2, microsomal glutathione S-transferase 2
  • Synonyms
    GST2, MGST-II
  • Links
    NCBI Gene ID: 4258
    neXtProt AC: NX_Q99735
    UniProt: Q99735

  • Chr Location
    4q31.1; chr4:139665768-139754618 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele display resistance to induced ER stress related cell death and mortality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    28
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000074604 Ensembl Gene Model | MGI Sequence Detail 22318 C57BL/6J ±  kb
    transcript ENSMUST00000099106 Ensembl | MGI Sequence Detail 603 Not Applicable  
    polypeptide ENSMUSP00000096705 Ensembl | MGI Sequence Detail 147 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000010391 microsomal glutathione S-transferase 2
      (term hierarchy)
    • EC
      1.11.1.-, 2.5.1.18, 4.4.1.20
    • InterPro Domains
      IPR001446 5-lipoxygenase-activating protein
      IPR023352 Membrane associated eicosanoid/glutathione metabolism-like domain superfamily
      IPR001129 Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein
      IPR050997 Membrane-associated proteins in eicosanoid and glutathione metabolism
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 28

      Microarray probesets 3
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 9
      Phenotypes 13
    • Earliest
      J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory