Vsig10 MGI Mouse Gene Detail - MGI:2448533 - V-set and immunoglobulin domain containing 10

Symbol

Vsig10
Name

V-set and immunoglobulin domain containing 10

Feature Type

protein coding gene
IDs

MGI:2448533
NCBI Gene: 231668
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr5:117457331-117493071 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 56.88 cM
Mapping Data

1 experiment

SNPs within 2kb

1022 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2448533	protein coding gene	Chr5:117457148-117493071 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029986	protein coding gene	Chr5:120391357-120439540 (+)
A/J	MGP_AJ_G0029950	protein coding gene	Chr5:115502069-115538024 (+)
AKR/J	MGP_AKRJ_G0029889	protein coding gene	Chr5:119234599-119270669 (+)
BALB/cJ	MGP_BALBcJ_G0029961	protein coding gene	Chr5:116920018-116956543 (+)
C3H/HeJ	MGP_C3HHeJ_G0029681	protein coding gene	Chr5:119749307-119791626 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030416	protein coding gene	Chr5:124977997-125020441 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027642	protein coding gene	Chr5:110264162-110299566 (+)
CAST/EiJ	MGP_CASTEiJ_G0029090	protein coding gene	Chr5:118757226-118795420 (+)
CBA/J	MGP_CBAJ_G0029649	protein coding gene	Chr5:129800142-129844069 (+)
DBA/2J	MGP_DBA2J_G0029799	protein coding gene	Chr5:115599120-115636592 (+)
FVB/NJ	MGP_FVBNJ_G0029755	protein coding gene	Chr5:114465508-114501639 (+)
LP/J	MGP_LPJ_G0029887	protein coding gene	Chr5:120897656-120935954 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029786	protein coding gene	Chr5:134026219-134063107 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030457	protein coding gene	Chr5:118756465-118795668 (+)
PWK/PhJ	MGP_PWKPhJ_G0028803	protein coding gene	Chr5:114288005-114329050 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028641	protein coding gene	Chr5:116315823-116361491 (+)
WSB/EiJ	MGP_WSBEiJ_G0029165	protein coding gene	Chr5:119327795-119367628 (+)

Human Ortholog

VSIG10, V-set and immunoglobulin domain containing 10

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

VSIG10, V-set and immunoglobulin domain containing 10
Links

HGNC:26078

NCBI Gene ID: 54621

neXtProt AC: NX_Q8N0Z9

UniProt: Q8N0Z9
Chr Location

12q24.23; chr12:118063593-118136026 (-) GRCh38

MGI Vertebrate Homology

Vsig10 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: VSIG10
Gene Tree

Vsig10

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

11
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Vsig10
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

33 strains or lines available

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All GO Annotations

2
GO References

2

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

22

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase vsig10

ZFIN vsig10

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All Sequences

40
RefSeq

2
UniProt

3
CCDS

CCDS19603.2

Ensembl

ENSMUSG00000066894 (Evidence)
NCBI Gene

231668

			Length	Strain/Species	Flank
genomic	231668	NCBI Gene Model \| MGI Sequence Detail	35741	C57BL/6J	± kb
transcript	NM_001033311	RefSeq \| MGI Sequence Detail	4054	C57BL/6
polypeptide	D3YX43	UniProt \| EBI \| MGI Sequence Detail	558	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000029851 V-set and immunoglobulin domain-containing protein 10

(term hierarchy)
InterPro Domains

IPR051275 Cellular adhesion and signaling domain-containing protein

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR013106 Immunoglobulin V-set domain
GlyGen

D3YX43 8 sites, 4 N-linked glycans (4 sites)

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All nucleic 22

cDNA 22

Microarray probesets 4

Summaries

All 32

Gene Ontology 2

Phenotypes 14
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Vsig10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr48376	Chr5:117456803-117456824 (+)	-517 bp
Tssr48377	Chr5:117457127-117457174 (+)	-180 bp
Tssr48378	Chr5:117457323-117457349 (+)	5 bp
Tssr48379	Chr5:117457357-117457391 (+)	43 bp
Tssr48380	Chr5:117457406-117457417 (+)	81 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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