Myo3b MGI Mouse Gene Detail - MGI:2448580

Symbol

Myo3b
Name

myosin IIIB
Synonyms

A430065P19Rik

Feature Type

protein coding gene
IDs

MGI:2448580
NCBI Gene: 329421
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr2:69869470-70259542 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 41.05 cM
Mapping Data

3 experiments

SNPs within 2kb

11365 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2448580	protein coding gene	Chr2:69869464-70259542 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025810	protein coding gene	Chr2:70049583-70466774 (+)
A/J	MGP_AJ_G0025787	protein coding gene	Chr2:67345600-67733585 (+)
AKR/J	MGP_AKRJ_G0025756	protein coding gene	Chr2:69169139-69575327 (+)
BALB/cJ	MGP_BALBcJ_G0025782	protein coding gene	Chr2:67504239-67918284 (+)
C3H/HeJ	MGP_C3HHeJ_G0025542	protein coding gene	Chr2:69399112-69791487 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026229	protein coding gene	Chr2:72169579-72591520 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023632	protein coding gene	Chr2:64574438-64963713 (+)
CAST/EiJ	MGP_CASTEiJ_G0025006	protein coding gene	Chr2:69531148-69934209 (+)
CBA/J	MGP_CBAJ_G0025522	protein coding gene	Chr2:74833801-75275147 (+)
DBA/2J	MGP_DBA2J_G0025653	protein coding gene	Chr2:66977071-67366524 (+)
FVB/NJ	MGP_FVBNJ_G0025616	protein coding gene	Chr2:66356673-66738936 (+)
LP/J	MGP_LPJ_G0025742	protein coding gene	Chr2:69907876-70312819 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025645	protein coding gene	Chr2:76894592-77308637 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026286	protein coding gene	Chr2:69263290-69670001 (+)
PWK/PhJ	MGP_PWKPhJ_G0024747	protein coding gene	Chr2:66828451-67217670 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024554	protein coding gene	Chr2:69499342-69882783 (+)
WSB/EiJ	MGP_WSBEiJ_G0025074	protein coding gene	Chr2:69687739-70099990 (+)

Human Ortholog

MYO3B, myosin IIIB

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MYO3B, myosin IIIB
Links

HGNC:15576

NCBI Gene ID: 140469

neXtProt AC: NX_Q8WXR4

UniProt: Q8WXR4
Chr Location

2q31.1; chr2:170178145-170655171 (+) GRCh38

MGI Vertebrate Homology

Myo3b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MYO3B
Gene Tree

Myo3b

less

Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

5
Targeted

3
Genomic Mutations

1 involving Myo3b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

86 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele show a subtle defect in stereocilia staircase step spacing in the extrastriolar regions of the utricle, but have normal hearing thresholds and no overt vestibular dysfunction.

less

All GO Annotations

55
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

745
Tissues

13
cDNA Data

11
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase myo3b

ZFIN myo3b

less

All Sequences

68
RefSeq

28
UniProt

4
CCDS

CCDS38139.1

Ensembl

ENSMUSG00000042064 (Evidence)
NCBI Gene

329421

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042064	Ensembl Gene Model \| MGI Sequence Detail	390073	C57BL/6J	± kb
transcript	ENSMUST00000060208	Ensembl \| MGI Sequence Detail	6256	Not Applicable
polypeptide	ENSMUSP00000055362	Ensembl \| MGI Sequence Detail	1333	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000010864 myosin-IIIB

(term hierarchy)
PDB

5ET0, 5ET1
EC

2.7.11.1
InterPro Domains

IPR036083 Class III myosin, motor domain

IPR000048 IQ motif, EF-hand binding site

IPR036961 Kinesin motor domain superfamily

IPR001609 Myosin head, motor domain

IPR052409 Myosin-III family with kinase activity

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

less

All nucleic 11

cDNA 11

Microarray probesets 3

less

MGI:2443983

Summaries

All 41

Developmental Gene Expression 3

Gene Ontology 10

Phenotypes 12
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Myo3b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr18187	Chr2:69869458-69869469 (+)	-6 bp
Tssr18188	Chr2:69869611-69869650 (+)	161 bp
Tssr18189	Chr2:69900377-69900420 (+)	30,929 bp
Tssr18190	Chr2:69922270-69922275 (+)	52,803 bp
Tssr18191	Chr2:69925315-69925328 (+)	55,852 bp
Tssr516	Chr2:69965695-69965718 (+)	96,237 bp
Tssr18192	Chr2:69973314-69973319 (+)	103,847 bp
Tssr18193	Chr2:70046159-70046166 (+)	176,693 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24