Afmid MGI Mouse Gene Detail - MGI:2448704

Symbol

Afmid
Name

arylformamidase
Synonyms

9030621K19Rik, formylase, formylkynureninase, Kf, kynurenine formamidase

Feature Type

protein coding gene
IDs

MGI:2448704
NCBI Gene: 71562
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr11:117716750-117730734 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 82.96 cM, cytoband E2
Mapping Data

2 experiments

SNPs within 2kb

492 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2448704	protein coding gene	Chr11:117716329-117730734 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019455	protein coding gene	Chr11:122108165-122124027 (+)
A/J	MGP_AJ_G0019423	protein coding gene	Chr11:116697954-116712256 (+)
AKR/J	MGP_AKRJ_G0019393	protein coding gene	Chr11:120251141-120266178 (+)
BALB/cJ	MGP_BALBcJ_G0019398	protein coding gene	Chr11:117069119-117083034 (+)
C3H/HeJ	MGP_C3HHeJ_G0019204	protein coding gene	Chr11:120533467-120550226 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019847	protein coding gene	Chr11:125833943-125849815 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017472	protein coding gene	Chr11:113705490-113719771 (+)
CAST/EiJ	MGP_CASTEiJ_G0018758	protein coding gene	Chr11:121959544-121973158 (+)
CBA/J	MGP_CBAJ_G0019175	protein coding gene	Chr11:130788687-130805768 (+)
DBA/2J	MGP_DBA2J_G0019287	protein coding gene	Chr11:116098752-116112846 (+)
FVB/NJ	MGP_FVBNJ_G0019279	protein coding gene	Chr11:115717684-115732039 (+)
LP/J	MGP_LPJ_G0019357	protein coding gene	Chr11:122433003-122448032 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019312	protein coding gene	Chr11:129749152-129763985 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019886	protein coding gene	Chr11:120900728-120916957 (+)
PWK/PhJ	MGP_PWKPhJ_G0018524	protein coding gene	Chr11:117454030-117470018 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018316	protein coding gene	Chr11:120629689-120645790 (+)
WSB/EiJ	MGP_WSBEiJ_G0018810	protein coding gene	Chr11:120866506-120880644 (+)

Human Ortholog

AFMID, arylformamidase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AFMID, arylformamidase
Synonyms

FKF, KF, KFA
Links

HGNC:20910

NCBI Gene ID: 125061

neXtProt AC: NX_Q63HM1

UniProt: Q63HM1
Chr Location

17q25.3; chr17:78187358-78207702 (+) GRCh38

MGI Vertebrate Homology

Afmid stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: AFMID
Gene Tree

Afmid

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Phenotype Summary

17 phenotypes from 3 alleles in 3 genetic backgrounds
2 phenotypes from multigenic genotypes
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

1
Gene trapped

1
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit polydipsia, polyuria and hyperglycemia. Mice homozygous for a full exon 2 deletion show impaired glucose tolerance due to reduced insulin secretion associated with reduced islet mass.

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All GO Annotations

7
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

811
Tissues

102
cDNA Data

51
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase afmid

ZFIN afmid

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All Sequences

64
RefSeq

23
UniProt

2
CCDS

CCDS25693.1

Ensembl

ENSMUSG00000017718 (Evidence)
NCBI Gene

71562

			Length	Strain/Species	Flank
genomic	ENSMUSG00000017718	Ensembl Gene Model \| MGI Sequence Detail	13985	C57BL/6J	± kb
transcript	ENSMUST00000149668	Ensembl \| MGI Sequence Detail	1583	Not Applicable
polypeptide	ENSMUSP00000119310	Ensembl \| MGI Sequence Detail	363	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000031721 kynurenine formamidase

(term hierarchy)
EC

3.5.1.9
InterPro Domains

IPR029058 Alpha/Beta hydrolase fold

IPR049492 BD-FAE-like domain

IPR050300 'GDXG' lipolytic enzyme

IPR027519 Kynurenine formamidase, vertebrates/fungi-type

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All nucleic 51

cDNA 51

Microarray probesets 3

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MGI:1918812

Summaries

All 43

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 16
Earliest

J:52807 Dobrovolsky VN, et al., Tk+/- mouse model for detecting in vivo mutation in an endogenous, autosomal gene. Mutat Res. 1999 Jan 25;423(1-2):125-36
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Afmid:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr106087	Chr11:117716711-117716752 (+)	-18 bp
Tssr106088	Chr11:117716759-117716795 (+)	27 bp
Tssr106089	Chr11:117720196-117720208 (+)	3,452 bp
Tssr106090	Chr11:117720316-117720336 (+)	3,576 bp
Tssr106091	Chr11:117721474-117721488 (+)	4,731 bp
Tssr106092	Chr11:117723065-117723093 (+)	6,329 bp
Tssr106093	Chr11:117723112-117723125 (+)	6,369 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24