Cadm4 MGI Mouse Gene Detail - MGI:2449088

Symbol

Cadm4
Name

cell adhesion molecule 4
Synonyms

Igsf4c, Necl-4, SynCAM 4, Tsll2

Feature Type

protein coding gene
IDs

MGI:2449088
NCBI Gene: 260299
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr7:24181448-24203958 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 11.03 cM, cytoband A3-B2
Mapping Data

2 experiments

SNPs within 2kb

601 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2449088	protein coding gene	Chr7:24181448-24203964 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031830	protein coding gene	Chr7:22805951-22831574 (+)
A/J	MGP_AJ_G0031809	protein coding gene	Chr7:22284089-22307803 (+)
AKR/J	MGP_AKRJ_G0031738	protein coding gene	Chr7:22784651-22807198 (+)
BALB/cJ	MGP_BALBcJ_G0031815	protein coding gene	Chr7:22498513-22522583 (+)
C3H/HeJ	MGP_C3HHeJ_G0031535	protein coding gene	Chr7:23199685-23227322 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032278	protein coding gene	Chr7:23557641-23581488 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029336	protein coding gene	Chr7:23756036-23778148 (+)
CAST/EiJ	MGP_CASTEiJ_G0030876	protein coding gene	Chr7:16671881-16701890 (+)
CBA/J	MGP_CBAJ_G0031500	protein coding gene	Chr7:24442762-24474125 (+)
DBA/2J	MGP_DBA2J_G0031654	protein coding gene	Chr7:22198031-22220444 (+)
FVB/NJ	MGP_FVBNJ_G0031607	protein coding gene	Chr7:22162514-22190119 (+)
LP/J	MGP_LPJ_G0031733	protein coding gene	Chr7:23164363-23189158 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031644	protein coding gene	Chr7:24212893-24237831 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032310	protein coding gene	Chr7:22503424-22526906 (+)
PWK/PhJ	MGP_PWKPhJ_G0030600	protein coding gene	Chr7:17089350-17112836 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030430	protein coding gene	Chr7:13832114-13858471 (+)
WSB/EiJ	MGP_WSBEiJ_G0030979	protein coding gene	Chr7:22627586-22652453 (+)

Human Ortholog

CADM4, cell adhesion molecule 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CADM4, cell adhesion molecule 4
Synonyms

IGSF4C, Necl-4, NECL4, synCAM4, TSLL2
Links

HGNC:30825

NCBI Gene ID: 199731

neXtProt AC: NX_Q8NFZ8

UniProt: Q8NFZ8
Chr Location

19q13.31; chr19:43622368-43641984 (-) GRCh38

MGI Vertebrate Homology

Cadm4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CADM4
Gene Tree

Cadm4

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Phenotype Summary

8 phenotypes from 2 alleles in 3 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

2
Gene trapped

1
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

14 strains or lines available

Mice homozygous for one null allele do not display myelination abnormalities. Mice with ubiquitous conditional deletion of the gene show myelination abnormalities, decreased nerve conduction velocity, hindlimb rigidity, limb grasping, and impaired coordination.

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All GO Annotations

34
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

726
Tissues

10
cDNA Data

26
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cadm4

ZFIN cadm4

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All Sequences

29
RefSeq

2
UniProt

1
CCDS

CCDS20951.1

Ensembl

ENSMUSG00000054793 (Evidence)
NCBI Gene

260299

			Length	Strain/Species	Flank
genomic	260299	NCBI Gene Model \| MGI Sequence Detail	22511	C57BL/6J	± kb
transcript	NM_153112	RefSeq \| MGI Sequence Detail	2155	C57BL/6
polypeptide	Q8R464	UniProt \| EBI \| MGI Sequence Detail	388	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000004963 cell adhesion molecule 4

(term hierarchy)
PDB

5ZO1, 5ZO2
InterPro Domains

IPR013162 CD80-like, immunoglobulin C2-set

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR013106 Immunoglobulin V-set domain

IPR003585 Neurexin/syndecan/glycophorin C
GlyGen

Q8R464 5 sites, 15 N-linked glycans (4 sites), 1 O-linked glycan (1 site)

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All nucleic 28

cDNA 26

Primer pair 1

Other 1

Microarray probesets 3

Summaries

All 44

Developmental Gene Expression 6

Gene Ontology 6

Phenotypes 10
Earliest

J:86990 Fukami T, et al., Isolation of the mouse Tsll1 and Tsll2 genes, orthologues of the human TSLC1-like genes 1 and 2 (TSLL1 and TSLL2). Gene. 2003 Dec 24;323:11-8
Latest

J:341975 Liu X, et al., Indispensable role of Nectin-like 4 in regulating synapse-related molecules, synaptic structure, and individual behavior. FASEB J. 2023 Jun;37(6):e22970

TSS for Cadm4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr64985	Chr7:24181405-24181412 (+)	-39 bp
Tssr64986	Chr7:24181416-24181501 (+)	11 bp
Tssr64987	Chr7:24199024-24199029 (+)	17,579 bp
Tssr64988	Chr7:24200153-24200163 (+)	18,710 bp
Tssr64989	Chr7:24201049-24201062 (+)	19,608 bp
Tssr64990	Chr7:24203917-24203925 (+)	22,473 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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