A2m MGI Mouse Gene Detail - MGI:2449119

Symbol

A2m
Name

alpha-2-macroglobulin
Synonyms

A2mp

Feature Type

protein coding gene
IDs

MGI:2449119
NCBI Gene: 232345
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr6:121612920-121656197 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 57.49 cM
Mapping Data

12 experiments

SNPs within 2kb

1254 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2449119	protein coding gene	Chr6:121612335-121656197 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031219	protein coding gene	Chr6:124595355-124636498 (+)
A/J	MGP_AJ_G0031188	protein coding gene	Chr6:119796913-119836547 (+)
AKR/J	MGP_AKRJ_G0031119	protein coding gene	Chr6:123027278-123066904 (+)
BALB/cJ	MGP_BALBcJ_G0031199	protein coding gene	Chr6:119565552-119607493 (+)
C3H/HeJ	MGP_C3HHeJ_G0030917	protein coding gene	Chr6:123048497-123089307 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031657	protein coding gene	Chr6:127775561-127822575 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028817	protein coding gene	Chr6:116710814-116713350 (+)
CAST/EiJ	MGP_CASTEiJ_G0030306	protein coding gene	Chr6:123512191-123551538 (+)
CBA/J	MGP_CBAJ_G0030882	protein coding gene	Chr6:132856140-132899046 (+)
DBA/2J	MGP_DBA2J_G0031038	protein coding gene	Chr6:118678411-118720803 (+)
FVB/NJ	MGP_FVBNJ_G0030990	protein coding gene	Chr6:117820950-117861296 (+)
LP/J	MGP_LPJ_G0031117	protein coding gene	Chr6:124574628-124617169 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031024	protein coding gene	Chr6:136791057-136840453 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031686	protein coding gene	Chr6:123062655-123102310 (+)
PWK/PhJ	MGP_PWKPhJ_G0030021	protein coding gene	Chr6:117727604-117769536 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029850	protein coding gene	Chr6:121799928-121840754 (+)
WSB/EiJ	MGP_WSBEiJ_G0030389	protein coding gene	Chr6:123359706-123400819 (+)

Human Ortholog

A2M, alpha-2-macroglobulin

Vertebrate Orthologs

7

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

A2M, alpha-2-macroglobulin
Synonyms

A2MD, CPAMD5, FWP007, S863-7
Links

HGNC:7

NCBI Gene ID: 2

neXtProt AC: NX_P01023

UniProt: P01023
Chr Location

12p13.31; chr12:9067664-9116229 (-) GRCh38

MGI Vertebrate Homology

A2m stringent orthology
1 human;1 mouse;1 rat;5 zebrafish
HCOP

vertebrate homology predictions: A2M
Gene Tree

A2m

Diseases

6 with human A2M associations

				Human Disease	Mouse Models
				Alzheimer's disease IDs Alzheimer's disease DOID:10652 ICD10CM:G30 ICD9CM:331.0 KEGG:05010 MESH:D000544 NCI:C2866 UMLS_CUI:C0002395
				background diabetic retinopathy IDs background diabetic retinopathy DOID:13208 ICD9CM:362.01 ICD9CM:362.03 NCI:C35668 UMLS_CUI:C0004606
				COVID-19 IDs COVID-19 DOID:0080600 ICD10CM:U07.1 MESH:D000086382 NCI:C171133 UMLS_CUI:C5203670
				multiple sclerosis IDs multiple sclerosis DOID:2377 ICD10CM:G35 ICD9CM:340 MESH:D009103 NCI:C3243 OMIM:612594 OMIM:612595 OMIM:612596 UMLS_CUI:C0026769
				obstructive lung disease IDs obstructive lung disease DOID:2320 MESH:D008173 UMLS_CUI:C0600260
				Parkinson's disease IDs Parkinson's disease DOID:14330 ICD10CM:G20 ICD9CM:332 ICD9CM:332.0 KEGG:05012 MESH:D010300 NCI:C26845 OMIM:PS168600 ORDO:2828 UMLS_CUI:C0030567

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

8 phenotype references

All Mutations and Alleles

6
Endonuclease-mediated

3
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

95 strains or lines available

less

All GO Annotations

43
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1000
Tissues

71
cDNA Data

57
Literature Summary

13

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase a2m

less

All Sequences

40
RefSeq

4
UniProt

2
CCDS

CCDS39617.1

Ensembl

ENSMUSG00000030111 (Evidence)
NCBI Gene

232345

			Length	Strain/Species	Flank
genomic	232345	NCBI Gene Model \| MGI Sequence Detail	43278	C57BL/6J	± kb
transcript	NM_175628	RefSeq \| MGI Sequence Detail	4687	ZRU/MplStud
polypeptide	Q6GQT1	UniProt \| EBI \| MGI Sequence Detail	1474	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000024845 alpha-2-macroglobulin

(term hierarchy)
InterPro Domains

IPR001599 Alpha-2-macroglobulin

IPR011625 Alpha-2-macroglobulin, bait region domain

IPR050473 Alpha-2-macroglobulin/Complement system

IPR019742 Alpha-2-macroglobulin, conserved site

IPR041813 Alpha-2-macroglobulin, TED domain

IPR011626 Alpha-macroglobulin-like, TED domain

IPR047565 Alpha-macroglobulin-like, thiol-ester bond-forming region

IPR009048 Alpha-macroglobulin, receptor-binding

IPR036595 Alpha-macroglobulin, receptor-binding domain superfamily

IPR014756 Immunoglobulin E-set

IPR013783 Immunoglobulin-like fold

IPR002890 Macroglobulin domain

IPR041555 Macroglobulin domain MG3

IPR040839 Macroglobulin domain MG4

IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
GlyGen

Q6GQT1 12 sites, 1 N-linked glycan (3 sites), 1 O-linked glycan (3 sites)

less

All nucleic 60

cDNA 57

Primer pair 3

Microarray probesets 3

Summaries

All 68

Developmental Gene Expression 13

Gene Ontology 8

Phenotypes 8
Earliest

J:30080 Hudson NW, et al., Subunit and primary structure of a mouse alpha-macroglobulin, a human alpha 2-macroglobulin homologue. Biochim Biophys Acta. 1982 Jun 4;704(2):290-303
Latest

J:357285 Koo HY, et al., Analysis of Meis2 knockout mice reveals Sonic hedgehog-mediated patterning of the cochlear duct. Dev Dyn. 2024 Oct 1;

TSS for A2m:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr58629	Chr6:121613177-121613196 (+)	267 bp
Tssr58630	Chr6:121613217-121613224 (+)	301 bp
Tssr58631	Chr6:121613227-121613238 (+)	313 bp
Tssr58632	Chr6:121615247-121615258 (+)	2,333 bp
Tssr58633	Chr6:121618293-121618311 (+)	5,382 bp
Tssr58634	Chr6:121621855-121621886 (+)	8,951 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24