Egfl7 MGI Mouse Gene Detail - MGI:2449923

Symbol

Egfl7
Name

EGF-like domain 7
Synonyms

vascular endothelial-statin, VE-statin, Zneu1

Feature Type

protein coding gene
IDs

MGI:2449923
NCBI Gene: 353156
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr2:26471095-26482694 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 18.95 cM, cytoband B
Mapping Data

1 experiment

SNPs within 2kb

385 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2449923	protein coding gene	Chr2:26470026-26483132 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025491	protein coding gene	Chr2:24539502-24554156 (+)
A/J	MGP_AJ_G0025468	protein coding gene	Chr2:23599436-23612502 (+)
AKR/J	MGP_AKRJ_G0025438	protein coding gene	Chr2:24362235-24375310 (+)
BALB/cJ	MGP_BALBcJ_G0025464	protein coding gene	Chr2:23709816-23723014 (+)
C3H/HeJ	MGP_C3HHeJ_G0025225	protein coding gene	Chr2:24324651-24338932 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025908	protein coding gene	Chr2:25337417-25353562 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023319	protein coding gene	Chr2:22477687-22490825 (+)
CAST/EiJ	MGP_CASTEiJ_G0024688	protein coding gene	Chr2:24200912-24215660 (+)
CBA/J	MGP_CBAJ_G0025203	protein coding gene	Chr2:26183092-26197838 (+)
DBA/2J	MGP_DBA2J_G0025336	protein coding gene	Chr2:23419934-23433022 (+)
FVB/NJ	MGP_FVBNJ_G0025298	protein coding gene	Chr2:23176880-23190307 (+)
LP/J	MGP_LPJ_G0025422	protein coding gene	Chr2:24480251-24497972 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025329	protein coding gene	Chr2:26327499-26340566 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025967	protein coding gene	Chr2:24319991-24333094 (+)
PWK/PhJ	MGP_PWKPhJ_G0024436	protein coding gene	Chr2:23228047-23241132 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024236	protein coding gene	Chr2:24456195-24471599 (+)
WSB/EiJ	MGP_WSBEiJ_G0024757	protein coding gene	Chr2:24427751-24441957 (+)

Human Ortholog

EGFL7, EGF like domain multiple 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EGFL7, EGF like domain multiple 7
Synonyms

NEU1, VE-STATIN, ZNEU1
Links

HGNC:20594

NCBI Gene ID: 51162

neXtProt AC: NX_Q9UHF1

UniProt: Q9UHF1
Chr Location

9q34.3; chr9:136658856-136672678 (+) GRCh38

MGI Vertebrate Homology

Egfl7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: EGFL7
Gene Tree

Egfl7

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Phenotype Summary

9 phenotypes from 4 alleles in 4 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

2
Gene trapped

2
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit some embryonic lethality with absent heartbeat and systemic edema, delayed vasculogenesis, decreased angiogenesis, abnormal adult vasculature, and low-level hypoxia. Mice homozygous for a null allele that does not disrupt Mirn126 expression are normal.

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All GO Annotations

18
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

966
Tissues

140
cDNA Data

68
Literature Summary

22

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA EGFL7

Xenbase egfl7

ZFIN egfl7

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All Sequences

89
RefSeq

8
UniProt

10
CCDS

CCDS15807.3, CCDS15808.3

Ensembl

ENSMUSG00000026921 (Evidence)
NCBI Gene

353156

			Length	Strain/Species	Flank
genomic	353156	NCBI Gene Model \| MGI Sequence Detail	11600	C57BL/6J	± kb
transcript	NM_198724	RefSeq \| MGI Sequence Detail	1387	C57BL/6
polypeptide	Q9QXT5	UniProt \| EBI \| MGI Sequence Detail	275	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000006931 epidermal growth factor-like protein 7

(term hierarchy)
InterPro Domains

IPR050969 Developmental Signaling Modulators

IPR018097 EGF-like calcium-binding, conserved site

IPR001881 EGF-like calcium-binding domain

IPR000742 EGF-like domain

IPR013111 EGF-like domain, extracellular

IPR011489 EMI domain

IPR049883 NOTCH1 EGF-like calcium-binding domain

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All nucleic 76

cDNA 70

Primer pair 6

Microarray probesets 4

Summaries

All 56

Developmental Gene Expression 22

Gene Ontology 9

Phenotypes 14
Earliest

J:47981 Xiong JW, et al., Large-scale screening for developmental genes in embryonic stem cells and embryoid bodies using retroviral entrapment vectors. Dev Dyn. 1998 Jun;212(2):181-97
Latest

J:330449 Rusidze M, et al., Loss of function of the maternal membrane oestrogen receptor ERalpha alters expansion of trophoblast cells and impacts mouse fertility. Development. 2022 Oct 1;149(19):dev200683

TSS for Egfl7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr16802	Chr2:26471023-26471035 (+)	-66 bp
Tssr16803	Chr2:26471036-26471051 (+)	-51 bp
Tssr16804	Chr2:26471062-26471073 (+)	-27 bp
Tssr16805	Chr2:26471078-26471081 (+)	-15 bp
Tssr16806	Chr2:26471089-26471105 (+)	2 bp
Tssr16807	Chr2:26471134-26471147 (+)	46 bp
Tssr16808	Chr2:26473870-26473886 (+)	2,783 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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