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Iqgap2 Gene Detail
Summary
  • Symbol
    Iqgap2
  • Name
    IQ motif containing GTPase activating protein 2
  • Synonyms
    4933417J23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2449975
    NCBI Gene: 544963
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:95763685-96028788 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 50.26 cM, cytoband D1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9005 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2449975
 protein coding gene Chr13:95763682-96028991 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020844
 protein coding gene Chr13:97112816-97390196 (-)
A/J MGP_AJ_G0020798
 protein coding gene Chr13:93463608-93734598 (-)
AKR/J MGP_AKRJ_G0020772
 protein coding gene Chr13:96321261-96595369 (-)
BALB/cJ MGP_BALBcJ_G0020795
 protein coding gene Chr13:94143268-94414677 (-)
C3H/HeJ MGP_C3HHeJ_G0020588
 protein coding gene Chr13:96008525-96289411 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021231
 protein coding gene Chr13:100055234-100340655 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018800
 protein coding gene Chr13:89295140-89554847 (-)
CAST/EiJ MGP_CASTEiJ_G0020107
 protein coding gene Chr13:95316371-95596185 (-)
CBA/J MGP_CBAJ_G0020547
 protein coding gene Chr13:104031785-104312900 (-)
DBA/2J MGP_DBA2J_G0020672
 protein coding gene Chr13:93242090-93513105 (-)
FVB/NJ MGP_FVBNJ_G0020653
 protein coding gene Chr13:92026812-92293414 (-)
LP/J MGP_LPJ_G0020747
 protein coding gene Chr13:97221193-97510192 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020681
 protein coding gene Chr13:104462496-104744015 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021271
 protein coding gene Chr13:95723194-95999936 (-)
PWK/PhJ MGP_PWKPhJ_G0019859
 protein coding gene Chr13:92026196-92295693 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019683
 protein coding gene Chr13:92014438-92292311 (-)
WSB/EiJ MGP_WSBEiJ_G0020164
 protein coding gene Chr13:96225396-96498433 (-)



Homology
more
  • Human Ortholog
    IQGAP2, IQ motif containing GTPase activating protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IQGAP2, IQ motif containing GTPase activating protein 2
  • Links
    NCBI Gene ID: 10788
    neXtProt AC: NX_Q13576
    UniProt: Q13576

  • Chr Location
    5q13.3; chr5:76403285-76708132 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Iqgap2 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display reduced survival with increased incidence of hepatocellular carcinomas, increased hepatocyte apoptosis, and hepatocyte mitochondrial abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    993
  • Tissues
    154
  • cDNA Data
    157
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 544963 NCBI Gene Model | MGI Sequence Detail 265104 C57BL/6J ±  kb
    transcript NM_027711 RefSeq | MGI Sequence Detail 5771 ZRU/MplStud  
    polypeptide Q3UQ44 UniProt | EBI | MGI Sequence Detail 1575 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 160
      cDNA 157
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1918438, MGI:2145287
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 5
      Phenotypes 15
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory