Arhgap32 MGI Mouse Gene Detail - MGI:2450166 - Rho GTPase activating protein 32

Symbol

Arhgap32
Name

Rho GTPase activating protein 32
Synonyms

3426406O18Rik, GC-GAP, Grit, p200RhoGAP, PX-RICS

Feature Type

protein coding gene
IDs

MGI:2450166
NCBI Gene: 330914
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr9:32027432-32179742 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 17.48 cM
Mapping Data

2 experiments

SNPs within 2kb

3440 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2450166	protein coding gene	Chr9:31927921-32179742 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034522	protein coding gene	Chr9:29846676-30009691 (+)
A/J	MGP_AJ_G0034500	protein coding gene	Chr9:29085485-29241519 (+)
AKR/J	MGP_AKRJ_G0034426	protein coding gene	Chr9:29714026-29875816 (+)
BALB/cJ	MGP_BALBcJ_G0034491	protein coding gene	Chr9:28979527-29133187 (+)
C3H/HeJ	MGP_C3HHeJ_G0034203	protein coding gene	Chr9:30058368-30220556 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035012	protein coding gene	Chr9:30863526-31029279 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031942	protein coding gene	Chr9:27887623-28038628 (+)
CAST/EiJ	MGP_CASTEiJ_G0033526	protein coding gene	Chr9:29893460-30083335 (+)
CBA/J	MGP_CBAJ_G0034177	protein coding gene	Chr9:31875578-32057634 (+)
DBA/2J	MGP_DBA2J_G0034334	protein coding gene	Chr9:29097354-29250308 (+)
FVB/NJ	MGP_FVBNJ_G0034277	protein coding gene	Chr9:28499217-28653600 (+)
LP/J	MGP_LPJ_G0034420	protein coding gene	Chr9:30060996-30229422 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034321	protein coding gene	Chr9:33510356-33689002 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035032	protein coding gene	Chr9:29698787-29864058 (+)
PWK/PhJ	MGP_PWKPhJ_G0033231	protein coding gene	Chr9:29048820-29209273 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033066	protein coding gene	Chr9:29817278-29975270 (+)
WSB/EiJ	MGP_WSBEiJ_G0033641	protein coding gene	Chr9:29448789-29611863 (+)

Human Ortholog

ARHGAP32, Rho GTPase activating protein 32

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARHGAP32, Rho GTPase activating protein 32
Synonyms

GC-GAP, GRIT, p200RhoGAP, p250GAP, PX-RICS, RICS
Links

HGNC:17399

NCBI Gene ID: 9743

neXtProt AC: NX_A7KAX9

UniProt: A7KAX9
Chr Location

11q24.3; chr11:128965060-129279632 (-) GRCh38

MGI Vertebrate Homology

Arhgap32 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ARHGAP32
Gene Tree

Arhgap32

Diseases

1 with Arhgap32 mouse models

Human Disease

Mouse Models

autism spectrum disorder

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

15 phenotypes from 1 allele in 2 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

102
Endonuclease-mediated

3
Gene trapped

98
Targeted

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

87 strains or lines available

Mice homozygous for a null mutation are fertile but display abnormal neurite growth.

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All GO Annotations

29
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

765
Tissues

18
cDNA Data

35
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase arhgap32

ZFIN arhgap32a, arhgap32b

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All Sequences

71
RefSeq

20
UniProt

5
CCDS

CCDS22951.3, CCDS57666.1

Ensembl

ENSMUSG00000041444 (Evidence)
NCBI Gene

330914

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041444	Ensembl Gene Model \| MGI Sequence Detail	152311	C57BL/6J	± kb
transcript	ENSMUST00000174641	Ensembl \| MGI Sequence Detail	13568	Not Applicable
polypeptide	ENSMUSP00000133898	Ensembl \| MGI Sequence Detail	2089	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000013998 rho/Cdc42/Rac GTPase-activating protein RICS

(term hierarchy)
InterPro Domains

IPR051576 PX Domain-Containing Rho GAP

IPR036871 PX domain superfamily

IPR042139 Rho GTPase-activating protein 32, PX domain

IPR000198 Rho GTPase-activating protein domain

IPR008936 Rho GTPase activation protein

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily
GlyGen

Q811P8 12 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (9 sites)

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All nucleic 35

cDNA 35

Microarray probesets 3

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MGI:1917927

Summaries

All 48

Developmental Gene Expression 3

Diseases 1

Gene Ontology 8

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:236753 Nakamura T, et al., PX-RICS-deficient mice mimic autism spectrum disorder in Jacobsen syndrome through impaired GABAA receptor trafficking. Nat Commun. 2016 Mar 16;7:10861

TSS for Arhgap32:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr84234	Chr9:32027275-32027292 (+)	-148 bp
Tssr84235	Chr9:32027302-32027328 (+)	-117 bp
Tssr84236	Chr9:32027336-32027345 (+)	-91 bp
Tssr2817	Chr9:32054715-32054717 (+)	27,284 bp
Tssr84237	Chr9:32070848-32070852 (+)	43,418 bp
Tssr84238	Chr9:32135407-32135421 (+)	107,982 bp
Tssr84239	Chr9:32135542-32135560 (+)	108,119 bp
Tssr84240	Chr9:32135564-32135577 (+)	108,139 bp
Tssr84241	Chr9:32135581-32135588 (+)	108,153 bp
Tssr84242	Chr9:32135601-32135616 (+)	108,177 bp
Tssr84243	Chr9:32135620-32135626 (+)	108,191 bp
Tssr84244	Chr9:32135753-32135793 (+)	108,341 bp
Tssr84245	Chr9:32150442-32150474 (+)	123,026 bp
Tssr84246	Chr9:32175956-32175960 (+)	148,526 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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