Tspoap1 MGI Mouse Gene Detail - MGI:2450877

Symbol

Tspoap1
Name

TSPO associated protein 1
Synonyms

Bzrap1, mKIAA0612, peripheral

Feature Type

protein coding gene
IDs

MGI:2450877
NCBI Gene: 207777
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr11:87651367-87676754 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 52.21 cM
Mapping Data

1 experiment

SNPs within 2kb

219 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2450877	protein coding gene	Chr11:87649022-87676754 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018911	protein coding gene	Chr11:89392775-89418614 (+)
A/J	MGP_AJ_G0018878	protein coding gene	Chr11:85946243-85972146 (+)
AKR/J	MGP_AKRJ_G0018848	protein coding gene	Chr11:88515809-88546266 (+)
BALB/cJ	MGP_BALBcJ_G0018851	protein coding gene	Chr11:86347937-86373306 (+)
C3H/HeJ	MGP_C3HHeJ_G0018665	protein coding gene	Chr11:88560572-88586772 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019303	protein coding gene	Chr11:92108335-92135197 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016936	protein coding gene	Chr11:82974008-82999710 (+)
CAST/EiJ	MGP_CASTEiJ_G0018220	protein coding gene	Chr11:89252494-89279605 (+)
CBA/J	MGP_CBAJ_G0018636	protein coding gene	Chr11:95977947-96003481 (+)
DBA/2J	MGP_DBA2J_G0018744	protein coding gene	Chr11:85500419-85526049 (+)
FVB/NJ	MGP_FVBNJ_G0018733	protein coding gene	Chr11:85006528-85031885 (+)
LP/J	MGP_LPJ_G0018814	protein coding gene	Chr11:89884332-89910937 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018760	protein coding gene	Chr11:96017638-96042991 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019343	protein coding gene	Chr11:88758439-88783785 (+)
PWK/PhJ	MGP_PWKPhJ_G0017990	protein coding gene	Chr11:86349703-86375156 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017783	protein coding gene	Chr11:88317535-88342841 (+)
WSB/EiJ	MGP_WSBEiJ_G0018271	protein coding gene	Chr11:88649491-88676505 (+)

Human Ortholog

TSPOAP1, TSPO associated protein 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TSPOAP1, TSPO associated protein 1
Synonyms

BZRAP1, DYT22, PBR-IP, PRAX-1, PRAX1, RIM-BP1, RIMBP1
Links

HGNC:16831

NCBI Gene ID: 9256

neXtProt AC: NX_O95153

UniProt: O95153
Chr Location

17q22; chr17:58301228-58328795 (-) GRCh38

MGI Vertebrate Homology

Tspoap1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: TSPOAP1
Gene Tree

Tspoap1

Diseases

2 with human TSPOAP1 associations

				Human Disease	Mouse Models
				dystonia 22, adult-onset IDs dystonia 22, adult-onset DOID:0060967 OMIM:620456
				dystonia 22, juvenile-onset IDs dystonia 22, juvenile-onset DOID:0060966 OMIM:620453

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
5 phenotypes from multigenic genotypes
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

1
Targeted

6
Genomic Mutations

2 involving Tspoap1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

51 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous double-KO with Rimbp2^tm1.2Geno does not exacerbate the phenotype of the latter single KO.

less

All GO Annotations

17
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

709
Tissues

1
cDNA Data

56
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tspoap1

less

All Sequences

86
RefSeq

26
UniProt

7
CCDS

CCDS48879.1

Ensembl

ENSMUSG00000034156 (Evidence)
NCBI Gene

207777

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034156	Ensembl Gene Model \| MGI Sequence Detail	25388	C57BL/6J	± kb
transcript	ENSMUST00000039627	Ensembl \| MGI Sequence Detail	7616	Not Applicable
polypeptide	ENSMUSP00000048063	Ensembl \| MGI Sequence Detail	1846	Not Applicable

less

UniProt

7 Sequences
Protein Ontology

PR:000004863 peripheral-type benzodiazepine receptor-associated protein 1

(term hierarchy)
InterPro Domains

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR013783 Immunoglobulin-like fold

IPR040325 RIMS-binding protein 1/2/3

IPR035753 RIMS-binding protein, second SH3 domain

IPR035755 RIMS-binding protein, third SH3 domain

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily
GlyGen

Q7TNF8 1 site, 1 O-linked glycan (1 site)

less

All nucleic 57

cDNA 56

Primer pair 1

Microarray probesets 2

Summaries

All 47

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 22
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tspoap1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103972	Chr11:87651359-87651377 (+)	1 bp
Tssr103973	Chr11:87651724-87651729 (+)	360 bp
Tssr103974	Chr11:87651888-87651893 (+)	524 bp
Tssr103975	Chr11:87652874-87652895 (+)	1,518 bp
Tssr103976	Chr11:87655528-87655558 (+)	4,176 bp
Tssr103977	Chr11:87665297-87665298 (+)	13,931 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24