Pde5a MGI Mouse Gene Detail - MGI:2651499 - phosphodiesterase 5A, cGMP-specific

Symbol

Pde5a
Name

phosphodiesterase 5A, cGMP-specific
Synonyms

Pde5, PDE5A1

Feature Type

protein coding gene
IDs

MGI:2651499
NCBI Gene: 242202
Alliance

gene page
Transcription Start Sites

20 TSS

Sequence Map

Chr3:122522822-122653023 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 53.69 cM
Mapping Data

2 experiments

SNPs within 2kb

3921 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2651499	protein coding gene	Chr3:122522596-122653023 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027841	protein coding gene	Chr3:125010844-125148928 (+)
A/J	MGP_AJ_G0027799	protein coding gene	Chr3:120826021-120959633 (+)
AKR/J	MGP_AKRJ_G0027765	protein coding gene	Chr3:123907626-124044240 (+)
BALB/cJ	MGP_BALBcJ_G0027811	protein coding gene	Chr3:120637938-120775000 (+)
C3H/HeJ	MGP_C3HHeJ_G0027542	protein coding gene	Chr3:124301155-124442784 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028257	protein coding gene	Chr3:129541003-129687993 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025596	protein coding gene	Chr3:116257682-116385994 (+)
CAST/EiJ	MGP_CASTEiJ_G0026998	protein coding gene	Chr3:123697649-123838975 (+)
CBA/J	MGP_CBAJ_G0027517	protein coding gene	Chr3:133928526-134067747 (+)
DBA/2J	MGP_DBA2J_G0027658	protein coding gene	Chr3:119955624-120084245 (+)
FVB/NJ	MGP_FVBNJ_G0027626	protein coding gene	Chr3:117568950-117701772 (+)
LP/J	MGP_LPJ_G0027768	protein coding gene	Chr3:126524953-126665411 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027656	protein coding gene	Chr3:141479537-141620020 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028313	protein coding gene	Chr3:123463129-123607237 (+)
PWK/PhJ	MGP_PWKPhJ_G0026724	protein coding gene	Chr3:119677218-119808751 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026547	protein coding gene	Chr3:121571873-121703936 (+)
WSB/EiJ	MGP_WSBEiJ_G0027078	protein coding gene	Chr3:124198005-124338506 (+)

Human Ortholog

PDE5A, phosphodiesterase 5A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PDE5A, phosphodiesterase 5A
Synonyms

CGB-PDE, CN5A, PDE5
Links

HGNC:8784

NCBI Gene ID: 8654

neXtProt AC: NX_O76074

UniProt: O76074
Chr Location

4q26; chr4:119494397-119628804 (-) GRCh38

MGI Vertebrate Homology

Pde5a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PDE5A
Gene Tree

Pde5a

Diseases

1 with human PDE5A associations

				Human Disease	Mouse Models
				IgA glomerulonephritis IDs IgA glomerulonephritis DOID:2986 EFO:0004194 MESH:D005922 NCI:C34643 OMIM:161950 UMLS_CUI:C0017661

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

5
Radiation induced

1
Targeted

1
Genomic Mutations

2 involving Pde5a
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

54 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice with a mutation that prevents luteinizing hormone-induced phosphorylation are viable, fertile and show no obvious morphological or behavioral abnormalities.

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All GO Annotations

32
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

921
Tissues

106
cDNA Data

31
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA PDE5A

Xenbase pde5a

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All Sequences

41
RefSeq

4
UniProt

4
CCDS

CCDS17812.1

Ensembl

ENSMUSG00000053965 (Evidence)
NCBI Gene

242202

			Length	Strain/Species	Flank
genomic	242202	NCBI Gene Model \| MGI Sequence Detail	130202	C57BL/6J	± kb
transcript	NM_001409793	RefSeq \| MGI Sequence Detail	7031	C57BL/6
polypeptide	Q8CG03	UniProt \| EBI \| MGI Sequence Detail	865	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000012477 cGMP-specific 3',5'-cyclic phosphodiesterase

(term hierarchy)
PDB

2K31
EC

3.1.4.-, 3.1.4.35
InterPro Domains

IPR023088 3'5'-cyclic nucleotide phosphodiesterase

IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily

IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site

IPR003018 GAF domain

IPR029016 GAF-like domain superfamily

IPR003607 HD/PDEase domain

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All nucleic 34

cDNA 31

Primer pair 3

Microarray probesets 1

Summaries

All 68

Developmental Gene Expression 7

Diseases 1

Gene Ontology 14

Phenotypes 12
Earliest

J:49444 Loughney K, et al., Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase. Gene. 1998 Aug 17;216(1):139-47
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Pde5a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr31509	Chr3:122522593-122522644 (+)	-203 bp
Tssr31510	Chr3:122522653-122522664 (+)	-163 bp
Tssr31511	Chr3:122522768-122522783 (+)	-46 bp
Tssr31512	Chr3:122522812-122522831 (+)	0 bp
Tssr31513	Chr3:122522847-122522882 (+)	43 bp
Tssr31514	Chr3:122523358-122523384 (+)	549 bp
Tssr31515	Chr3:122523499-122523518 (+)	687 bp
Tssr31516	Chr3:122523519-122523543 (+)	709 bp
Tssr31517	Chr3:122523567-122523578 (+)	751 bp
Tssr31518	Chr3:122523696-122523706 (+)	879 bp
Tssr31519	Chr3:122523762-122523768 (+)	943 bp
Tssr31520	Chr3:122523785-122523802 (+)	972 bp
Tssr31521	Chr3:122523865-122523888 (+)	1,055 bp
Tssr31522	Chr3:122523901-122523910 (+)	1,084 bp
Tssr31523	Chr3:122627998-122628008 (+)	105,181 bp
Tssr31524	Chr3:122628144-122628152 (+)	105,326 bp
Tssr31525	Chr3:122628209-122628233 (+)	105,399 bp
Tssr31526	Chr3:122628403-122628420 (+)	105,590 bp
Tssr31527	Chr3:122628430-122628447 (+)	105,617 bp
Tssr31528	Chr3:122650075-122650089 (+)	127,260 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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