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Il1f10 Gene Detail
Summary
  • Symbol
    Il1f10
  • Name
    interleukin 1 family, member 10
  • Feature Type
    protein coding gene
  • IDs
    MGI:2652548
    NCBI Gene: 215274
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr2:24181208-24183832 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 16.32 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    179 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2652548
 protein coding gene Chr2:24177095-24184236 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025407
 protein coding gene Chr2:22085755-22088391 (+)
A/J MGP_AJ_G0025384
 protein coding gene Chr2:21236686-21239309 (+)
AKR/J MGP_AKRJ_G0025354
 protein coding gene Chr2:21965492-21968115 (+)
BALB/cJ MGP_BALBcJ_G0025380
 protein coding gene Chr2:21347097-21349721 (+)
C3H/HeJ MGP_C3HHeJ_G0025141
 protein coding gene Chr2:21903745-21906369 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025824
 protein coding gene Chr2:22796158-22798782 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023235
 protein coding gene Chr2:20163536-20166727 (+)
CAST/EiJ MGP_CASTEiJ_G0024604
 protein coding gene Chr2:21734784-21737484 (+)
CBA/J MGP_CBAJ_G0025119
 protein coding gene Chr2:23600954-23603651 (+)
DBA/2J MGP_DBA2J_G0025252
 protein coding gene Chr2:21095677-21098316 (+)
FVB/NJ MGP_FVBNJ_G0025214
 protein coding gene Chr2:20837350-20839965 (+)
LP/J MGP_LPJ_G0025338
 protein coding gene Chr2:22016917-22019574 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025245
 protein coding gene Chr2:23839314-23841938 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025883
 protein coding gene Chr2:21888332-21890956 (+)
PWK/PhJ MGP_PWKPhJ_G0024352
 protein coding gene Chr2:20880454-20883093 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024152
 protein coding gene Chr2:22004503-22007122 (+)
WSB/EiJ MGP_WSBEiJ_G0024673
 protein coding gene Chr2:21961781-21964429 (+)



Homology
more
  • Human Ortholog
    IL1F10, interleukin 1 family member 10
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL1F10, interleukin 1 family member 10
  • Synonyms
    FIL1-theta, FKSG75, IL-1HY2, IL1HY2, IL1-theta, IL-38
  • Links
    NCBI Gene ID: 84639
    neXtProt AC: NX_Q8WWZ1
    UniProt: Q8WWZ1

  • Chr Location
    2q14.1; chr2:113067970-113075843 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Mice homozygous for a null allele are healthy, fertile and do not show any overt phenotype. Induced psoriasis develops similarly to wild-type mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000046845 Ensembl Gene Model | MGI Sequence Detail 2625 C57BL/6J ±  kb
transcript ENSMUST00000058056 Ensembl | MGI Sequence Detail 538 Not Applicable  
polypeptide ENSMUSP00000063004 Ensembl | MGI Sequence Detail 152 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 2
References
more
  • Summaries
    All 34
    Gene Ontology 5
    Phenotypes 15
  • Earliest
    J:76507 Taylor SL, et al., Genomic organization of the interleukin-1 locus. Genomics. 2002 May;79(5):726-33
  • Latest
    J:354202 da Silva P, et al., Neutralizing IL-38 activates gammadelta T cell-dependent antitumor immunity and sensitizes for chemotherapy. J Immunother Cancer. 2024 Aug 28;12(8)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory