Baiap2l2 MGI Mouse Gene Detail - MGI:2652819 - BAI1-associated protein 2-like 2

Symbol

Baiap2l2
Name

BAI1-associated protein 2-like 2
Synonyms

MGC:56984

Feature Type

protein coding gene
IDs

MGI:2652819
NCBI Gene: 207495
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr15:79142395-79169737 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 37.70 cM
Mapping Data

1 experiment

SNPs within 2kb

933 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2652819	protein coding gene	Chr15:79142395-79169756 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022070	protein coding gene	Chr15:79515031-79542279 (-)
A/J	MGP_AJ_G0022031	protein coding gene	Chr15:76774967-76803839 (-)
AKR/J	MGP_AKRJ_G0022006	protein coding gene	Chr15:78909381-78940252 (-)
BALB/cJ	MGP_BALBcJ_G0022037	protein coding gene	Chr15:76763459-76791285 (-)
C3H/HeJ	MGP_C3HHeJ_G0021808	protein coding gene	Chr15:78900038-78931295 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022480	protein coding gene	Chr15:82636500-82681915 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020010	protein coding gene	Chr15:73256108-73283851 (-)
CAST/EiJ	MGP_CASTEiJ_G0021329	protein coding gene	Chr15:79603249-79630614 (-)
CBA/J	MGP_CBAJ_G0021773	protein coding gene	Chr15:85194938-85239426 (-)
DBA/2J	MGP_DBA2J_G0021902	protein coding gene	Chr15:76252483-76280804 (-)
FVB/NJ	MGP_FVBNJ_G0021880	protein coding gene	Chr15:75285659-75314378 (-)
LP/J	MGP_LPJ_G0021970	protein coding gene	Chr15:79707948-79735028 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021900	protein coding gene	Chr15:90341319-90372258 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022494	protein coding gene	Chr15:78925251-78957246 (-)
PWK/PhJ	MGP_PWKPhJ_G0021071	protein coding gene	Chr15:76263648-76291610 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020908	protein coding gene	Chr15:78734533-78768380 (-)
WSB/EiJ	MGP_WSBEiJ_G0021381	protein coding gene	Chr15:79308604-79343425 (-)

Human Ortholog

BAIAP2L2, BAR/IMD domain containing adaptor protein 2 like 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BAIAP2L2, BAR/IMD domain containing adaptor protein 2 like 2
Links

HGNC:26203

NCBI Gene ID: 80115

neXtProt AC: NX_Q6UXY1

UniProt: Q6UXY1
Chr Location

22q13.1; chr22:38084652-38111015 (-) GRCh38

MGI Vertebrate Homology

Baiap2l2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: BAIAP2L2
Gene Tree

Baiap2l2

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References

1 with disease annotations

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Phenotype Summary

19 phenotypes from 3 alleles in 4 genetic backgrounds
31 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

2
Radiation induced

2
Targeted

3
Genomic Mutations

3 involving Baiap2l2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit early and progressive hearing loss associated with loss of stereocilia and reduced.

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All GO Annotations

17
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

2
cDNA Data

15
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase baiap2l2

ZFIN baiap2l2a, baiap2l2b

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All Sequences

42
RefSeq

12
UniProt

1
CCDS

CCDS37140.1

Ensembl

ENSMUSG00000018126 (Evidence)
NCBI Gene

207495

			Length	Strain/Species	Flank
genomic	ENSMUSG00000018126	Ensembl Gene Model \| MGI Sequence Detail	27343	C57BL/6J	± kb
transcript	ENSMUST00000165408	Ensembl \| MGI Sequence Detail	2100	Not Applicable
polypeptide	ENSMUSP00000127816	Ensembl \| MGI Sequence Detail	522	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000004634 brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2

(term hierarchy)
PDB

3OK8
InterPro Domains

IPR027267 AH/BAR domain superfamily

IPR030126 Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2, I-BAR domain

IPR027681 I-BAR domain containing protein IRSp53/IRTKS/Pinkbar

IPR013606 IMD/I-BAR domain

IPR035593 Pinkbar, SH3

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

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All nucleic 15

cDNA 15

Microarray probesets 1

Summaries

All 56

Developmental Gene Expression 2

Diseases 1

Gene Ontology 7

Phenotypes 31
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Baiap2l2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr135326	Chr15:79169702-79169716 (-)	28 bp
Tssr135325	Chr15:79169670-79169698 (-)	53 bp
Tssr135324	Chr15:79169650-79169665 (-)	79 bp
Tssr135323	Chr15:79169620-79169635 (-)	109 bp
Tssr135322	Chr15:79167734-79167782 (-)	1,979 bp
Tssr135321	Chr15:79149983-79149992 (-)	19,749 bp
Tssr135320	Chr15:79145477-79145509 (-)	24,244 bp
Tssr135319	Chr15:79142814-79142847 (-)	26,906 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24