Setd1b MGI Mouse Gene Detail - MGI:2652820

Symbol

Setd1b
Name

SET domain containing 1B
Synonyms

KMT2G, MGC:39035, mKIAA1076

Feature Type

protein coding gene
IDs

MGI:2652820
NCBI Gene: 208043
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr5:123280256-123306692 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 62.80 cM
Mapping Data

2 experiments

SNPs within 2kb

501 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2652820	protein coding gene	Chr5:123280109-123306693 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030065	protein coding gene	Chr5:126828783-126857584 (+)
A/J	MGP_AJ_G0030030	protein coding gene	Chr5:121575639-121602105 (+)
AKR/J	MGP_AKRJ_G0029966	protein coding gene	Chr5:125491261-125519481 (+)
BALB/cJ	MGP_BALBcJ_G0030041	protein coding gene	Chr5:122910006-122936614 (+)
C3H/HeJ	MGP_C3HHeJ_G0029758	protein coding gene	Chr5:126116891-126156645 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030494	protein coding gene	Chr5:131722270-131749932 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027720	protein coding gene	Chr5:116158949-116183049 (+)
CAST/EiJ	MGP_CASTEiJ_G0029167	protein coding gene	Chr5:125220935-125250627 (+)
CBA/J	MGP_CBAJ_G0029728	protein coding gene	Chr5:136886252-136921307 (+)
DBA/2J	MGP_DBA2J_G0029878	protein coding gene	Chr5:121621694-121645459 (+)
FVB/NJ	MGP_FVBNJ_G0029834	protein coding gene	Chr5:120623005-120650296 (+)
LP/J	MGP_LPJ_G0029967	protein coding gene	Chr5:127365041-127392473 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029865	protein coding gene	Chr5:140568614-140596249 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030535	protein coding gene	Chr5:125088613-125123022 (+)
PWK/PhJ	MGP_PWKPhJ_G0028881	protein coding gene	Chr5:120409481-120436836 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028718	protein coding gene	Chr5:122783823-122807717 (+)
WSB/EiJ	MGP_WSBEiJ_G0029242	protein coding gene	Chr5:125757388-125785632 (+)

Human Ortholog

SETD1B, SET domain containing 1B, histone lysine methyltransferase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SETD1B, SET domain containing 1B, histone lysine methyltransferase
Synonyms

IDDSELD, KMT2G, Set1B
Links

HGNC:29187

NCBI Gene ID: 23067

neXtProt AC: NX_Q9UPS6

UniProt: Q9UPS6
Chr Location

12q24.31; chr12:121790155-121832656 (+) GRCh38

MGI Vertebrate Homology

Setd1b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SETD1B
Gene Tree

Setd1b

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

23
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

13
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Setd1b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

51 strains or lines available

Homozygous mutant animals died during organogenesis by E11.5.

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All GO Annotations

21
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

852
Tissues

139
cDNA Data

13
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase setd1b

ZFIN setd1ba

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All Sequences

55
RefSeq

6
UniProt

3
CCDS

CCDS59684.1

Ensembl

ENSMUSG00000038384 (Evidence)
NCBI Gene

208043

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038384	Ensembl Gene Model \| MGI Sequence Detail	26437	C57BL/6J	± kb
transcript	ENSMUST00000056053	Ensembl \| MGI Sequence Detail	7362	Not Applicable
polypeptide	ENSMUSP00000134686	Ensembl \| MGI Sequence Detail	1985	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000014720 histone-lysine N-methyltransferase SETD1B

(term hierarchy)
EC

2.1.1.364
InterPro Domains

IPR024657 COMPASS complex Set1 subunit, N-SET domain

IPR044570 Histone-lysine N-methyltransferase Set1-like

IPR037841 Histone-lysine N-methyltransferase SETD1A/B-like, SET domain

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR003616 Post-SET domain

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain

IPR034468 Set1B, RNA recognition motif

IPR001214 SET domain

IPR046341 SET domain superfamily
GlyGen

Q8CFT2 1 site, 1 O-linked glycan (1 site)

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All nucleic 16

cDNA 13

Primer pair 3

Microarray probesets 4

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MGI:2140755

Summaries

All 55

Developmental Gene Expression 7

Gene Ontology 9

Phenotypes 18
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Setd1b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr48764	Chr5:123279287-123279303 (+)	-961 bp
Tssr48765	Chr5:123279492-123279499 (+)	-760 bp
Tssr48766	Chr5:123280173-123280184 (+)	-77 bp
Tssr48767	Chr5:123280250-123280292 (+)	15 bp
Tssr48768	Chr5:123280293-123280349 (+)	65 bp
Tssr48769	Chr5:123286319-123286332 (+)	6,070 bp
Tssr48770	Chr5:123305432-123305455 (+)	25,188 bp
Tssr48771	Chr5:123305640-123305661 (+)	25,395 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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