Asic4 MGI Mouse Gene Detail - MGI:2652846 - acid-sensing ion channel family member 4

Symbol

Asic4
Name

acid-sensing ion channel family member 4
Synonyms

Accn4

Feature Type

protein coding gene
IDs

MGI:2652846
NCBI Gene: 241118
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr1:75427080-75450987 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 39.08 cM
Mapping Data

1 experiment

SNPs within 2kb

558 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2652846	protein coding gene	Chr1:75426467-75450987 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016188	protein coding gene	Chr1:76023127-76052102 (+)
A/J	MGP_AJ_G0016171	protein coding gene	Chr1:73373539-73398415 (+)
AKR/J	MGP_AKRJ_G0016128	protein coding gene	Chr1:75409606-75432355 (+)
BALB/cJ	MGP_BALBcJ_G0016126	protein coding gene	Chr1:73436853-73461019 (+)
C3H/HeJ	MGP_C3HHeJ_G0015957	protein coding gene	Chr1:75739859-75765256 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016579	protein coding gene	Chr1:78974486-79006305 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014300	protein coding gene	Chr1:68932726-68957551 (+)
CAST/EiJ	MGP_CASTEiJ_G0015541	protein coding gene	Chr1:75085135-75110262 (+)
CBA/J	MGP_CBAJ_G0015930	protein coding gene	Chr1:81545609-81583830 (+)
DBA/2J	MGP_DBA2J_G0016031	protein coding gene	Chr1:72693741-72717764 (+)
FVB/NJ	MGP_FVBNJ_G0016034	protein coding gene	Chr1:71897558-71923928 (+)
LP/J	MGP_LPJ_G0016103	protein coding gene	Chr1:77148827-77179474 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016054	protein coding gene	Chr1:84891418-84918368 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016626	protein coding gene	Chr1:75477103-75502248 (+)
PWK/PhJ	MGP_PWKPhJ_G0015328	protein coding gene	Chr1:72169640-72193722 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015106	protein coding gene	Chr1:74836405-74858214 (+)
WSB/EiJ	MGP_WSBEiJ_G0015603	protein coding gene	Chr1:75288315-75311819 (+)

Human Ortholog

ASIC4, acid sensing ion channel subunit family member 4

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ASIC4, acid sensing ion channel subunit family member 4
Synonyms

ACCN4, BNAC4
Links

HGNC:21263

NCBI Gene ID: 55515

neXtProt AC: NX_Q96FT7

UniProt: Q96FT7
Chr Location

2q35; chr2:219507093-219538772 (+) GRCh38

MGI Vertebrate Homology

Asic4 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ASIC4
Gene Tree

Asic4

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References

1 with disease annotations

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Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

2
Spontaneous

1
Targeted

6
Genomic Mutations

4 involving Asic4
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous knockout increases the fear response in the predator-odor induced fear test and increases anxiety in open field and elevated plus maze tests.

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All GO Annotations

7
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

823
Tissues

23
cDNA Data

11
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase asic4

ZFIN asic4a, asic4b

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All Sequences

35
RefSeq

4
UniProt

2
CCDS

CCDS15073.1

Ensembl

ENSMUSG00000033007 (Evidence)
NCBI Gene

241118

			Length	Strain/Species	Flank
genomic	ENSMUSG00000033007	Ensembl Gene Model \| MGI Sequence Detail	23908	C57BL/6J	± kb
transcript	ENSMUST00000037708	Ensembl \| MGI Sequence Detail	2464	Not Applicable
polypeptide	ENSMUSP00000045598	Ensembl \| MGI Sequence Detail	539	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000003617 acid-sensing ion channel 4

(term hierarchy)
InterPro Domains

IPR001873 Epithelial sodium channel

IPR020903 Epithelial sodium channel, conserved site
GlyGen

Q7TNS7 8 sites, 8 N-linked glycans (7 sites)

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All nucleic 11

cDNA 11

Microarray probesets 2

Summaries

All 53

Developmental Gene Expression 4

Diseases 1

Gene Ontology 5

Phenotypes 30
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Asic4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125	Chr1:75426367-75426368 (+)	-712 bp
Tssr7535	Chr1:75427144-75427160 (+)	72 bp
Tssr7536	Chr1:75427226-75427258 (+)	162 bp
Tssr7537	Chr1:75427357-75427375 (+)	286 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24