Dock5 MGI Mouse Gene Detail - MGI:2652871 - dedicator of cytokinesis 5

Symbol

Dock5
Name

dedicator of cytokinesis 5
Synonyms

1110060D06Rik, lr2, MGC:28003, rlc

Feature Type

protein coding gene
IDs

MGI:2652871
NCBI Gene: 68813
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr14:67989584-68170891 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 34.66 cM
Mapping Data

11 experiments

SNPs within 2kb

5726 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2652871	protein coding gene	Chr14:67989377-68171021 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021507	protein coding gene	Chr14:62496941-62681685 (-)
A/J	MGP_AJ_G0021466	protein coding gene	Chr14:60995120-61176713 (-)
AKR/J	MGP_AKRJ_G0021442	protein coding gene	Chr14:63075945-63262950 (-)
BALB/cJ	MGP_BALBcJ_G0021472	protein coding gene	Chr14:60989995-61171918 (-)
C3H/HeJ	MGP_C3HHeJ_G0021249	protein coding gene	Chr14:62803391-62992461 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021911	protein coding gene	Chr14:65334396-65524465 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019451	protein coding gene	Chr14:58903881-59088280 (-)
CAST/EiJ	MGP_CASTEiJ_G0020766	protein coding gene	Chr14:59301788-59497083 (-)
CBA/J	MGP_CBAJ_G0021216	protein coding gene	Chr14:67347475-67538065 (-)
DBA/2J	MGP_DBA2J_G0021339	protein coding gene	Chr14:60628095-60811367 (-)
FVB/NJ	MGP_FVBNJ_G0021318	protein coding gene	Chr14:60032957-60218065 (-)
LP/J	MGP_LPJ_G0021414	protein coding gene	Chr14:63550577-63741565 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021347	protein coding gene	Chr14:66321209-66508297 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021934	protein coding gene	Chr14:62306721-62501197 (-)
PWK/PhJ	MGP_PWKPhJ_G0020510	protein coding gene	Chr14:57393485-57579402 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020343	protein coding gene	Chr14:58250163-58440464 (-)
WSB/EiJ	MGP_WSBEiJ_G0020819	protein coding gene	Chr14:62635594-62822622 (-)

Human Ortholog

DOCK5, dedicator of cytokinesis 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DOCK5, dedicator of cytokinesis 5
Links

HGNC:23476

NCBI Gene ID: 80005

neXtProt AC: NX_Q9H7D0

UniProt: Q9H7D0
Chr Location

8p21.2; chr8:25184689-25418082 (+) GRCh38

MGI Vertebrate Homology

Dock5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DOCK5
Gene Tree

Dock5

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
4 phenotypes from multigenic genotypes
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

103
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

99
Spontaneous

1
Targeted

1
Genomic Mutations

1 involving Dock5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

158 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mutations at this locus result in lens abnormalities involving cataracts and rupturing of the lens nucleus.

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All GO Annotations

30
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

764
Tissues

33
cDNA Data

16
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dock5

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All Sequences

44
RefSeq

4
UniProt

3
CCDS

CCDS36963.1

Ensembl

ENSMUSG00000044447 (Evidence)
NCBI Gene

68813

			Length	Strain/Species	Flank
genomic	ENSMUSG00000044447	Ensembl Gene Model \| MGI Sequence Detail	181308	C57BL/6J	± kb
transcript	ENSMUST00000039135	Ensembl \| MGI Sequence Detail	9988	Not Applicable
polypeptide	ENSMUSP00000036674	Ensembl \| MGI Sequence Detail	1868	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000006622 dedicator of cytokinesis protein 5

(term hierarchy)
InterPro Domains

IPR016024 Armadillo-type fold

IPR027007 C2 DOCK-type domain

IPR035892 C2 domain superfamily

IPR026791 Dedicator of cytokinesis

IPR043161 Dedicator of cytokinesis, C-terminal, lobe A

IPR043162 Dedicator of cytokinesis, C-terminal, lobe C

IPR032376 Dedicator of cytokinesis, N-terminal domain

IPR042455 Dedicator of cytokinesis, N-terminal, subdomain 1

IPR047025 Dedicator of cytokinesis protein 1/5, SH3 domain

IPR030717 Dedicator of cytokinesis protein 5, DHR2 domain

IPR027357 DOCKER domain

IPR046769 DOCKER, Lobe A

IPR046770 DOCKER, Lobe B

IPR046773 DOCKER, Lobe C

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily
GlyGen

B2RY04 2 sites, 2 N-linked glycans (2 sites)

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All nucleic 20

cDNA 16

Primer pair 3

Other 1

Microarray probesets 4

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MGD-MRK-36554, MGI:107974, MGI:1101762, MGI:1916063, MGI:2145688, MGI:2145709

Summaries

All 58

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 25
Earliest

J:35527 Matsushima Y, et al., Mapping of rupture of lens cataract (rlc) on mouse chromosome 14. Genomics. 1996 15;36(3):553-4
Latest

J:335036 Kunimura K, et al., DOCK2 regulates MRGPRX2/B2-mediated mast cell degranulation and drug-induced anaphylaxis. J Allergy Clin Immunol. 2023 Feb 17;

TSS for Dock5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr129398	Chr14:68171184-68171212 (-)	-307 bp
Tssr129397	Chr14:68171141-68171155 (-)	-257 bp
Tssr129396	Chr14:68170961-68171034 (-)	-107 bp
Tssr129395	Chr14:68170873-68170899 (-)	5 bp
Tssr129393	Chr14:68017911-68017925 (-)	152,973 bp
Tssr129392	Chr14:68017866-68017890 (-)	153,013 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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