Nynrin MGI Mouse Gene Detail - MGI:2652872 - NYN domain and retroviral integrase containing

Symbol

Nynrin
Name

NYN domain and retroviral integrase containing

Feature Type

protein coding gene
IDs

MGI:2652872
NCBI Gene: 277154
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr14:56091572-56112193 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 28.19 cM
Mapping Data

1 experiment

SNPs within 2kb

474 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2652872	protein coding gene	Chr14:56091467-56112193 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021374	protein coding gene	Chr14:49905872-49929223 (+)
A/J	MGP_AJ_G0021333	protein coding gene	Chr14:48902203-48922906 (+)
AKR/J	MGP_AKRJ_G0021309	protein coding gene	Chr14:50665089-50686988 (+)
BALB/cJ	MGP_BALBcJ_G0021337	protein coding gene	Chr14:48876603-48897243 (+)
C3H/HeJ	MGP_C3HHeJ_G0021117	protein coding gene	Chr14:50351585-50372227 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021775	protein coding gene	Chr14:52401969-52429270 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019322	protein coding gene	Chr14:47263683-47286306 (+)
CAST/EiJ	MGP_CASTEiJ_G0020636	protein coding gene	Chr14:46602354-46624763 (+)
CBA/J	MGP_CBAJ_G0021084	protein coding gene	Chr14:53969795-53993602 (+)
DBA/2J	MGP_DBA2J_G0021205	protein coding gene	Chr14:48617852-48638604 (+)
FVB/NJ	MGP_FVBNJ_G0021187	protein coding gene	Chr14:48070845-48091493 (+)
LP/J	MGP_LPJ_G0021279	protein coding gene	Chr14:50948265-50970156 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021211	protein coding gene	Chr14:53326186-53347906 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021802	protein coding gene	Chr14:49842266-49863264 (+)
PWK/PhJ	MGP_PWKPhJ_G0020383	protein coding gene	Chr14:45158525-45179333 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020211	protein coding gene	Chr14:45834642-45856373 (+)
WSB/EiJ	MGP_WSBEiJ_G0020689	protein coding gene	Chr14:50120502-50143836 (+)

Human Ortholog

NYNRIN, NYN domain and retroviral integrase containing

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NYNRIN, NYN domain and retroviral integrase containing
Synonyms

CGIN1, KIAA1305
Links

HGNC:20165

NCBI Gene ID: 57523

neXtProt AC: NX_Q9P2P1

UniProt: Q9P2P1
Chr Location

14q12; chr14:24399003-24419283 (+) GRCh38

MGI Vertebrate Homology

Nynrin stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: NYNRIN
Gene Tree

Nynrin

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

7
Genomic Mutations

1 involving Nynrin
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

67 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

8
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

72

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

38
RefSeq

2
UniProt

2
CCDS

CCDS49501.1

Ensembl

ENSMUSG00000075592 (Evidence)
NCBI Gene

277154

			Length	Strain/Species	Flank
genomic	277154	NCBI Gene Model \| MGI Sequence Detail	20622	C57BL/6J	± kb
transcript	NM_001040072	RefSeq \| MGI Sequence Detail	7422	C57BL/6
polypeptide	Q5DTZ0	UniProt \| EBI \| MGI Sequence Detail	1840	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000031047 protein NYNRIN

(term hierarchy)
InterPro Domains

IPR043502 DNA/RNA polymerase superfamily

IPR001584 Integrase, catalytic core

IPR041588 Integrase zinc-binding domain

IPR043128 Reverse transcriptase/Diguanylate cyclase domain

IPR041577 Reverse transcriptase/retrotransposon-derived protein, RNase H-like domain

IPR002156 Ribonuclease H domain

IPR012337 Ribonuclease H-like superfamily

IPR036397 Ribonuclease H superfamily

IPR021869 Ribonuclease Zc3h12a-like, NYN domain

IPR051101 ZC3H12/N4BP1 Ribonuclease and Regulator

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All nucleic 72

cDNA 72

Microarray probesets 4

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MGI:2145554, MGI:2145867

Summaries

All 31

Gene Ontology 3

Phenotypes 9
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Nynrin:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125824	Chr14:56091435-56091446 (+)	-131 bp
Tssr125825	Chr14:56091454-56091490 (+)	-100 bp
Tssr125826	Chr14:56091582-56091663 (+)	51 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24