Wnk3 MGI Mouse Gene Detail - MGI:2652875 - WNK lysine deficient protein kinase 3

Symbol

Wnk3
Name

WNK lysine deficient protein kinase 3
Synonyms

Prkwnk3, PRKWNK3, Wnk3, Wnk3-ps

Feature Type

protein coding gene
IDs

MGI:2652875
NCBI Gene: 279561
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

ChrX:149981074-150103148 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 68.46 cM
Mapping Data

1 experiment

SNPs within 2kb

1918 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2652875	protein coding gene	ChrX:149951774-150103190 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0036176	protein coding gene	ChrX:148905353-149065414 (+)
A/J	MGP_AJ_G0036152	protein coding gene	ChrX:148121620-148264628 (+)
AKR/J	MGP_AKRJ_G0036078	protein coding gene	ChrX:152898189-153054936 (+)
BALB/cJ	MGP_BALBcJ_G0036143	protein coding gene	ChrX:146310749-146460053 (+)
C3H/HeJ	MGP_C3HHeJ_G0035851	protein coding gene	ChrX:149115781-149269442 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036668	protein coding gene	ChrX:153171696-153299439 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033492	protein coding gene	ChrX:139871710-140002630 (+)
CAST/EiJ	MGP_CASTEiJ_G0035142	protein coding gene	ChrX:128586794-128703546 (+)
CBA/J	MGP_CBAJ_G0035828	protein coding gene	ChrX:157663080-157824915 (+)
DBA/2J	MGP_DBA2J_G0035986	protein coding gene	ChrX:147196835-147360354 (+)
FVB/NJ	MGP_FVBNJ_G0035920	protein coding gene	ChrX:146340322-146485517 (+)
LP/J	MGP_LPJ_G0036077	protein coding gene	ChrX:150019171-150138036 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035956	protein coding gene	ChrX:165803371-165947328 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036703	protein coding gene	ChrX:148440597-148559486 (+)
PWK/PhJ	MGP_PWKPhJ_G0034836	protein coding gene	ChrX:125525287-125680037 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034662	protein coding gene	ChrX:129048782-129165328 (+)
WSB/EiJ	MGP_WSBEiJ_G0035277	protein coding gene	ChrX:146511891-146661838 (+)

Human Ortholog

WNK3, WNK lysine deficient protein kinase 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

WNK3, WNK lysine deficient protein kinase 3
Synonyms

MRXS2, PRKWNK3, PRS
Links

HGNC:14543

NCBI Gene ID: 65267

neXtProt AC: NX_Q9BYP7

UniProt: Q9BYP7
Chr Location

Xp11.22; chrX:54192823-54358900 (-) GRCh38

MGI Vertebrate Homology

Wnk3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: WNK3
Gene Tree

Wnk3

Diseases

1 with human WNK3 associations

				Human Disease	Mouse Models
				Prieto syndrome IDs Prieto syndrome DOID:0060805 OMIM:309610 ORDO:2958

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
1 images
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

4
Gene trapped

4
Targeted

1
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit lower blood pressure when fed a low-salt diet.

less

All GO Annotations

76
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

2
cDNA Data

8
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase wnk3

ZFIN wnk3

less

All Sequences

64
RefSeq

22
UniProt

2
CCDS

CCDS72450.1, CCDS72451.1

Ensembl

ENSMUSG00000041245 (Evidence)
NCBI Gene

279561

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041245	Ensembl Gene Model \| MGI Sequence Detail	122075	C57BL/6J	± kb
transcript	ENSMUST00000184392	Ensembl \| MGI Sequence Detail	5394	Not Applicable
polypeptide	ENSMUSP00000139037	Ensembl \| MGI Sequence Detail	1757	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000017433 serine/threonine-protein kinase WNK3

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

IPR024678 Serine/threonine-protein kinase OSR1/WNK, CCT domain

IPR050588 With No Lysine (K) Ser/Thr Protein Kinase
GlyGen

Q80XP9 5 sites, 1 O-linked glycan (5 sites)

less

All nucleic 8

cDNA 8

Microarray probesets 3

less

MGI:2182463

Summaries

All 45

Developmental Gene Expression 1

Gene Ontology 12

Phenotypes 15
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:315133 Lim WM, et al., WNK3 Maintains the GABAergic Inhibitory Tone, Synaptic Excitation and Neuronal Excitability via Regulation of KCC2 Cotransporter in Mature Neurons. Front Mol Neurosci. 2021;14:762142

TSS for Wnk3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr5700	ChrX:149983005-149983011 (+)	1,934 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24