Mapk15 MGI Mouse Gene Detail - MGI:2652894 - mitogen-activated protein kinase 15

Symbol

Mapk15
Name

mitogen-activated protein kinase 15
Synonyms

MGC:56865, MGC:56903

Feature Type

protein coding gene
IDs

MGI:2652894
NCBI Gene: 332110
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr15:75865618-75871003 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 35.20 cM
Mapping Data

2 experiments

SNPs within 2kb

158 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2652894	protein coding gene	Chr15:75865581-75871003 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021970	protein coding gene	Chr15:76046026-76051409 (+)
A/J	MGP_AJ_G0021928	protein coding gene	Chr15:73276199-73281582 (+)
AKR/J	MGP_AKRJ_G0021911	protein coding gene	Chr15:75258263-75263646 (+)
BALB/cJ	MGP_BALBcJ_G0021937	protein coding gene	Chr15:73296331-73301714 (+)
C3H/HeJ	MGP_C3HHeJ_G0021709	protein coding gene	Chr15:75315502-75320885 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022377	protein coding gene	Chr15:78883799-78889182 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019906	protein coding gene	Chr15:69947168-69952535 (+)
CAST/EiJ	MGP_CASTEiJ_G0021228	protein coding gene	Chr15:76106746-76112156 (+)
CBA/J	MGP_CBAJ_G0021676	protein coding gene	Chr15:81395309-81400692 (+)
DBA/2J	MGP_DBA2J_G0021801	protein coding gene	Chr15:72806744-72812127 (+)
FVB/NJ	MGP_FVBNJ_G0021782	protein coding gene	Chr15:71857076-71862471 (+)
LP/J	MGP_LPJ_G0021872	protein coding gene	Chr15:76126085-76131468 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021806	protein coding gene	Chr15:86698325-86703711 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022397	protein coding gene	Chr15:75506084-75511467 (+)
PWK/PhJ	MGP_PWKPhJ_G0020969	protein coding gene	Chr15:72950327-72955728 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020808	protein coding gene	Chr15:75224894-75230285 (+)
WSB/EiJ	MGP_WSBEiJ_G0021280	protein coding gene	Chr15:75589017-75594403 (+)

Human Ortholog

MAPK15, mitogen-activated protein kinase 15

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MAPK15, mitogen-activated protein kinase 15
Synonyms

ERK7, ERK8
Links

HGNC:24667

NCBI Gene ID: 225689

neXtProt AC: NX_Q8TD08

UniProt: Q8TD08
Chr Location

8q24.3; chr8:143716340-143722458 (+) GRCh38

MGI Vertebrate Homology

Mapk15 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MAPK15
Gene Tree

Mapk15

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References

1 with disease annotations

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
27 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

3
Radiation induced

2
Targeted

3
Genomic Mutations

5 involving Mapk15
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available

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All GO Annotations

69
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

848
Tissues

31
cDNA Data

9
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mapk15

ZFIN mapk15

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All Sequences

81
RefSeq

46
UniProt

3
CCDS

CCDS27558.1

Ensembl

ENSMUSG00000063704 (Evidence)
NCBI Gene

332110

			Length	Strain/Species	Flank
genomic	ENSMUSG00000063704	Ensembl Gene Model \| MGI Sequence Detail	5386	C57BL/6J	± kb
transcript	ENSMUST00000089669	Ensembl \| MGI Sequence Detail	1931	Not Applicable
polypeptide	ENSMUSP00000087098	Ensembl \| MGI Sequence Detail	549	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000010155 mitogen-activated protein kinase 15

(term hierarchy)
EC

2.7.11.24
InterPro Domains

IPR050117 Mitogen-activated protein kinase

IPR003527 Mitogen-activated protein (MAP) kinase, conserved site

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily
GlyGen

Q80Y86 1 site, 1 O-linked glycan (1 site)

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All nucleic 9

cDNA 9

Microarray probesets 2

Summaries

All 59

Developmental Gene Expression 2

Diseases 1

Gene Ontology 12

Phenotypes 27
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mapk15:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr131699	Chr15:75865574-75865583 (+)	-39 bp
Tssr131700	Chr15:75865605-75865681 (+)	25 bp
Tssr131701	Chr15:75868611-75868627 (+)	3,001 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24