Amigo1 MGI Mouse Gene Detail - MGI:2653612 - adhesion molecule with Ig like domain 1

Symbol

Amigo1
Name

adhesion molecule with Ig like domain 1

Feature Type

protein coding gene
IDs

MGI:2653612
NCBI Gene: 229715
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr3:108093651-108099602 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 46.86 cM
Mapping Data

1 experiment

SNPs within 2kb

159 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2653612	protein coding gene	Chr3:108093605-108099602 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027768	protein coding gene	Chr3:109723453-109729404 (+)
A/J	MGP_AJ_G0027728	protein coding gene	Chr3:106246847-106252798 (+)
AKR/J	MGP_AKRJ_G0027693	protein coding gene	Chr3:108831256-108837207 (+)
BALB/cJ	MGP_BALBcJ_G0027740	protein coding gene	Chr3:105948016-105953961 (+)
C3H/HeJ	MGP_C3HHeJ_G0027470	protein coding gene	Chr3:109176697-109182648 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028184	protein coding gene	Chr3:113827823-113833774 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025522	protein coding gene	Chr3:102398317-102404263 (+)
CAST/EiJ	MGP_CASTEiJ_G0026926	protein coding gene	Chr3:108562029-108567459 (+)
CBA/J	MGP_CBAJ_G0027445	protein coding gene	Chr3:117689436-117695387 (+)
DBA/2J	MGP_DBA2J_G0027587	protein coding gene	Chr3:105428459-105434410 (+)
FVB/NJ	MGP_FVBNJ_G0027555	protein coding gene	Chr3:103315919-103321866 (+)
LP/J	MGP_LPJ_G0027694	protein coding gene	Chr3:111143428-111149379 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027585	protein coding gene	Chr3:123759405-123765356 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028239	protein coding gene	Chr3:108431658-108437614 (+)
PWK/PhJ	MGP_PWKPhJ_G0026652	protein coding gene	Chr3:105178462-105183896 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026472	protein coding gene	Chr3:106567965-106573467 (+)
WSB/EiJ	MGP_WSBEiJ_G0027006	protein coding gene	Chr3:108960116-108966067 (+)

Human Ortholog

AMIGO1, adhesion molecule with Ig like domain 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AMIGO1, adhesion molecule with Ig like domain 1
Synonyms

ALI2, AMIGO, AMIGO-1
Links

HGNC:20824

NCBI Gene ID: 57463

neXtProt AC: NX_Q86WK6

UniProt: Q86WK6
Chr Location

1p13.3; chr1:109504178-109509738 (-) GRCh38

MGI Vertebrate Homology

Amigo1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: AMIGO1
Gene Tree

Amigo1

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References

1 with disease annotations

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Phenotype Summary

5 phenotypes from 1 allele in 3 genetic backgrounds
1 phenotype from multigenic genotypes
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Amigo1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available

Mice homozygous for a null allele show a reduced size of retinal horizontal cell axons with no changes in the size of their dendrites or the ability of both arbors to form connections. The changes in horizontal cell axons are matched by changes in synaptic partner dendrites to stabilize retinal function.

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All GO Annotations

33
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

839
Tissues

80
cDNA Data

7
Literature Summary

10

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase amigo1

ZFIN amigo1

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All Sequences

63
RefSeq

20
UniProt

3
CCDS

CCDS17753.1, CCDS71305.1

Ensembl

ENSMUSG00000050947 (Evidence)
NCBI Gene

229715

			Length	Strain/Species	Flank
genomic	ENSMUSG00000050947	Ensembl Gene Model \| MGI Sequence Detail	5952	C57BL/6J	± kb
transcript	ENSMUST00000106656	Ensembl \| MGI Sequence Detail	5482	Not Applicable
polypeptide	ENSMUSP00000102267	Ensembl \| MGI Sequence Detail	492	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000003991 amphoterin-induced protein 1

(term hierarchy)
PDB

2XOT
InterPro Domains

IPR031283 Amphoterin-induced protein

IPR000483 Cysteine-rich flanking region, C-terminal

IPR013098 Immunoglobulin I-set

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR001611 Leucine-rich repeat

IPR032675 Leucine-rich repeat domain superfamily

IPR003591 Leucine-rich repeat, typical subtype
GlyGen

Q80ZD8 5 sites, 3 N-linked glycans (2 sites)

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All nucleic 11

cDNA 7

Primer pair 3

Other 1

Microarray probesets 6

Summaries

All 44

Developmental Gene Expression 10

Diseases 1

Gene Ontology 7

Phenotypes 12
Earliest

J:18891 Ramamoorthy S, et al., Functional characterization and chromosomal localization of a cloned taurine transporter from human placenta. Biochem J. 1994 Jun 15;300(Pt 3):893-900
Latest

J:347599 Raja R, et al., Insertion of a neomycin selection cassette in the Amigo1 locus alters gene expression in the olfactory epithelium leading to region-specific defects in olfactory receptor neuron development. Genesis. 2024 Apr;62(2):e23594

TSS for Amigo1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr31235	Chr3:108093648-108093723 (+)	35 bp
Tssr31236	Chr3:108093726-108093740 (+)	82 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24