Agap1 MGI Mouse Gene Detail - MGI:2653690 - ArfGAP with GTPase domain, ankyrin repeat and PH domain 1

Symbol

Agap1
Name

ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
Synonyms

Centg2, Ggap1, mKIAA1099

Feature Type

protein coding gene
IDs

MGI:2653690
NCBI Gene: 347722
Alliance

gene page
Transcription Start Sites

23 TSS

Sequence Map

Chr1:89382533-89823004 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 45.06 cM
Mapping Data

1 experiment

SNPs within 2kb

10670 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2653690	protein coding gene	Chr1:89382528-89825339 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016290	protein coding gene	Chr1:90903718-91359471 (+)
A/J	MGP_AJ_G0016271	protein coding gene	Chr1:87644265-88096640 (+)
AKR/J	MGP_AKRJ_G0016232	protein coding gene	Chr1:90230646-90695920 (+)
BALB/cJ	MGP_BALBcJ_G0016227	protein coding gene	Chr1:87800141-88253984 (+)
C3H/HeJ	MGP_C3HHeJ_G0016056	protein coding gene	Chr1:90450317-90910619 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016686	protein coding gene	Chr1:94433924-94897897 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014404	protein coding gene	Chr1:81935016-82373465 (+)
CAST/EiJ	MGP_CASTEiJ_G0015641	protein coding gene	Chr1:89772033-90234337 (+)
CBA/J	MGP_CBAJ_G0016032	protein coding gene	Chr1:97462655-97937229 (+)
DBA/2J	MGP_DBA2J_G0016135	protein coding gene	Chr1:86873051-87320654 (+)
FVB/NJ	MGP_FVBNJ_G0016134	protein coding gene	Chr1:85891452-86337750 (+)
LP/J	MGP_LPJ_G0016206	protein coding gene	Chr1:92045070-92498243 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016159	protein coding gene	Chr1:100755406-101218805 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016726	protein coding gene	Chr1:90266887-90722444 (+)
PWK/PhJ	MGP_PWKPhJ_G0015425	protein coding gene	Chr1:86269983-86715098 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015208	protein coding gene	Chr1:89180828-89621199 (+)
WSB/EiJ	MGP_WSBEiJ_G0015699	protein coding gene	Chr1:89989977-90454185 (+)

Human Ortholog

AGAP1, ArfGAP with GTPase domain, ankyrin repeat and PH domain 1

Vertebrate Orthologs

7

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AGAP1, ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
Synonyms

AGAP-1, CENTG2, cnt-g2, GGAP1
Links

HGNC:16922

NCBI Gene ID: 116987

neXtProt AC: NX_Q9UPQ3

UniProt: Q9UPQ3
Chr Location

2q37.2; chr2:235494043-236131793 (+) GRCh38

Human Ortholog

AGAP11, ArfGAP with GTPase domain, ankyrin repeat and PH domain 11
Links

HGNC:29421

NCBI Gene ID: 119385

neXtProt AC: NX_Q8TF27

UniProt: Q8TF27
Chr Location

10q23.2; chr10:86970336-87010226 (+) GRCh38

Human Ortholog

AGAP5, ArfGAP with GTPase domain, ankyrin repeat and PH domain 5
Synonyms

CTGLF2
Links

HGNC:23467

NCBI Gene ID: 729092

neXtProt AC: NX_A6NIR3

UniProt: A6NIR3
Chr Location

10q22.2

Human Ortholog

AGAP7P, ArfGAP with GTPase domain, ankyrin repeat and PH domain 7, pseudogene
Synonyms

AGAP-7, AGAP7, bA109G10.1, CTGLF4
Links

HGNC:23465

NCBI Gene ID: 653268

UniProt: Q5VUJ5
Chr Location

chr10:46109495-46131678 (+) GRCh38

Human Ortholog

AGAP9, ArfGAP with GTPase domain, ankyrin repeat and PH domain 9
Synonyms

AGAP-9, bA301J7.2, CTGLF6
Links

HGNC:23463

NCBI Gene ID: 642517

neXtProt AC: NX_Q5VTM2

UniProt: Q5VTM2
Chr Location

10q11.22; chr10:47501854-47523638 (-) GRCh38

MGI Vertebrate Homology

Agap1 stringent orthology
5 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: AGAP1, AGAP11, AGAP5, AGAP7P, AGAP9
Gene Tree

Agap1

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Phenotype Summary

16 phenotypes from 1 allele in 1 genetic background
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

44
Chemically induced (other)

1
Gene trapped

40
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Agap1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

88 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

9
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

921
Tissues

62
cDNA Data

144
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA AGAP1

Xenbase agap1

ZFIN agap1

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All Sequences

62
RefSeq

4
UniProt

6
CCDS

CCDS15148.1, CCDS15149.1

Ensembl

ENSMUSG00000055013 (Evidence)
NCBI Gene

347722

			Length	Strain/Species	Flank
genomic	347722	NCBI Gene Model \| MGI Sequence Detail	440472	C57BL/6J	± kb
transcript	NM_178119	RefSeq \| MGI Sequence Detail	9581	C57BL/6
polypeptide	Q8BXK8	UniProt \| EBI \| MGI Sequence Detail	857	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000003813 Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

(term hierarchy)
InterPro Domains

IPR002110 Ankyrin repeat

IPR036770 Ankyrin repeat-containing domain superfamily

IPR038508 ArfGAP domain superfamily

IPR037278 ARFGAP/RecO-like zinc finger

IPR051282 Arf-GAP with GTPase, ANK repeat and PH domain-containing protein

IPR001164 Arf GTPase activating protein

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR001806 Small GTPase
GlyGen

Q8BXK8 1 site, 1 N-linked glycan (1 site)

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All nucleic 146

cDNA 144

Primer pair 1

Other 1

Microarray probesets 6

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MGI:2138732

Summaries

All 47

Developmental Gene Expression 5

Gene Ontology 4

Phenotypes 18
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Agap1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr7989	Chr1:89382491-89382607 (+)	16 bp
Tssr7990	Chr1:89382608-89382642 (+)	92 bp
Tssr7991	Chr1:89382655-89382670 (+)	130 bp
Tssr7992	Chr1:89383026-89383030 (+)	495 bp
Tssr7993	Chr1:89391628-89391632 (+)	9,097 bp
Tssr7995	Chr1:89507869-89507902 (+)	125,353 bp
Tssr7996	Chr1:89507905-89507924 (+)	125,382 bp
Tssr7997	Chr1:89507926-89507937 (+)	125,399 bp
Tssr7998	Chr1:89507952-89507964 (+)	125,425 bp
Tssr7999	Chr1:89507967-89507978 (+)	125,440 bp
Tssr8000	Chr1:89507984-89508008 (+)	125,463 bp
Tssr8001	Chr1:89508010-89508024 (+)	125,484 bp
Tssr8002	Chr1:89508037-89508048 (+)	125,510 bp
Tssr8003	Chr1:89530946-89530982 (+)	148,431 bp
Tssr8004	Chr1:89587056-89587085 (+)	204,538 bp
Tssr8005	Chr1:89665419-89665424 (+)	282,889 bp
Tssr8006	Chr1:89665928-89665952 (+)	283,407 bp
Tssr8007	Chr1:89674718-89674726 (+)	292,189 bp
Tssr8008	Chr1:89695449-89695468 (+)	312,926 bp
Tssr8009	Chr1:89711185-89711190 (+)	328,655 bp
Tssr8010	Chr1:89718986-89718990 (+)	336,455 bp
Tssr8011	Chr1:89794118-89794123 (+)	411,588 bp
Tssr8012	Chr1:89798829-89798859 (+)	416,311 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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