Asb16 MGI Mouse Gene Detail - MGI:2654437 - ankyrin repeat and SOCS box-containing 16

Symbol

Asb16
Name

ankyrin repeat and SOCS box-containing 16

Feature Type

protein coding gene
IDs

MGI:2654437
NCBI Gene: 217217
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:102159577-102170280 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 66.29 cM
Mapping Data

1 experiment

SNPs within 2kb

395 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2654437	protein coding gene	Chr11:102159569-102170288 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019228	protein coding gene	Chr11:105227797-105240601 (+)
A/J	MGP_AJ_G0019196	protein coding gene	Chr11:100782773-100793448 (+)
AKR/J	MGP_AKRJ_G0019165	protein coding gene	Chr11:103905959-103916258 (+)
BALB/cJ	MGP_BALBcJ_G0019170	protein coding gene	Chr11:101272166-101283141 (+)
C3H/HeJ	MGP_C3HHeJ_G0018979	protein coding gene	Chr11:104107683-104119018 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019619	protein coding gene	Chr11:108506576-108519705 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017245	protein coding gene	Chr11:98214751-98225759 (+)
CAST/EiJ	MGP_CASTEiJ_G0018533	protein coding gene	Chr11:105084047-105096420 (+)
CBA/J	MGP_CBAJ_G0018948	protein coding gene	Chr11:112977634-112991499 (+)
DBA/2J	MGP_DBA2J_G0019060	protein coding gene	Chr11:100307338-100318680 (+)
FVB/NJ	MGP_FVBNJ_G0019050	protein coding gene	Chr11:99836304-99849449 (+)
LP/J	MGP_LPJ_G0019129	protein coding gene	Chr11:105745186-105758162 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019081	protein coding gene	Chr11:112492954-112503277 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019657	protein coding gene	Chr11:104265811-104280209 (+)
PWK/PhJ	MGP_PWKPhJ_G0018296	protein coding gene	Chr11:101370653-101382263 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018088	protein coding gene	Chr11:104022530-104034352 (+)
WSB/EiJ	MGP_WSBEiJ_G0018582	protein coding gene	Chr11:104262897-104274498 (+)

Human Ortholog

ASB16, ankyrin repeat and SOCS box containing 16

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ASB16, ankyrin repeat and SOCS box containing 16
Links

HGNC:19768

NCBI Gene ID: 92591

neXtProt AC: NX_Q96NS5

UniProt: Q96NS5
Chr Location

17q21.31; chr17:44170447-44179084 (+) GRCh38

MGI Vertebrate Homology

Asb16 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ASB16
Gene Tree

Asb16

less

Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

1
Gene trapped

4
Targeted

1
Genomic Mutations

1 involving Asb16
Incidental Mutations

APF
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

2
GO References

2

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

11

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase asb16

less

All Sequences

35
RefSeq

2
UniProt

5
CCDS

CCDS25493.1

Ensembl

ENSMUSG00000034768 (Evidence)
NCBI Gene

217217

			Length	Strain/Species	Flank
genomic	217217	NCBI Gene Model \| MGI Sequence Detail	10704	C57BL/6J	± kb
transcript	NM_148953	RefSeq \| MGI Sequence Detail	2827	C57BL/6
polypeptide	Q8VHS5	UniProt \| EBI \| MGI Sequence Detail	453	Not Applicable

less

UniProt

5 Sequences
Protein Ontology

PR:000004348 ankyrin repeat and SOCS box protein 16

(term hierarchy)
InterPro Domains

IPR002110 Ankyrin repeat

IPR050663 Ankyrin Repeat and SOCS Box

IPR051573 Ankyrin repeat and SOCS box domain-containing protein

IPR036770 Ankyrin repeat-containing domain superfamily

IPR001496 SOCS box domain

IPR036036 SOCS box-like domain superfamily

less

All nucleic 11

cDNA 11

Microarray probesets 2

Summaries

All 25

Gene Ontology 2

Phenotypes 10
Earliest

J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Asb16:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105203	Chr11:102159558-102159587 (+)	-4 bp
Tssr105204	Chr11:102159595-102159604 (+)	23 bp
Tssr105205	Chr11:102159605-102159614 (+)	33 bp
Tssr105206	Chr11:102167483-102167515 (+)	7,922 bp
Tssr105207	Chr11:102167631-102167659 (+)	8,068 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24