Otud7b MGI Mouse Gene Detail - MGI:2654703

Symbol

Otud7b
Name

OTU domain containing 7B
Synonyms

2900060B22Rik, 4930463P07Rik, Za20d1

Feature Type

protein coding gene
IDs

MGI:2654703
NCBI Gene: 229603
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr3:96011839-96068446 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 41.65 cM
Mapping Data

3 experiments

SNPs within 2kb

916 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2654703	protein coding gene	Chr3:96011759-96068446 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027604	protein coding gene	Chr3:96914991-96972023 (+)
A/J	MGP_AJ_G0027563	protein coding gene	Chr3:93867664-93928050 (+)
AKR/J	MGP_AKRJ_G0027530	protein coding gene	Chr3:96066473-96123040 (+)
BALB/cJ	MGP_BALBcJ_G0027575	protein coding gene	Chr3:93648508-93705439 (+)
C3H/HeJ	MGP_C3HHeJ_G0027308	protein coding gene	Chr3:96356134-96412938 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028023	protein coding gene	Chr3:100462263-100518797 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025363	protein coding gene	Chr3:90193226-90251498 (+)
CAST/EiJ	MGP_CASTEiJ_G0026758	protein coding gene	Chr3:95642229-95698937 (+)
CBA/J	MGP_CBAJ_G0027285	protein coding gene	Chr3:104148507-104207751 (+)
DBA/2J	MGP_DBA2J_G0027424	protein coding gene	Chr3:93161709-93218189 (+)
FVB/NJ	MGP_FVBNJ_G0027395	protein coding gene	Chr3:91237393-91294108 (+)
LP/J	MGP_LPJ_G0027533	protein coding gene	Chr3:98218721-98276714 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027422	protein coding gene	Chr3:110246482-110309778 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028077	protein coding gene	Chr3:95700846-95757596 (+)
PWK/PhJ	MGP_PWKPhJ_G0026486	protein coding gene	Chr3:93057222-93114545 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026307	protein coding gene	Chr3:94005165-94063256 (+)
WSB/EiJ	MGP_WSBEiJ_G0026840	protein coding gene	Chr3:96098364-96155122 (+)

Human Ortholog

OTUD7B, OTU deubiquitinase 7B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

OTUD7B, OTU deubiquitinase 7B
Synonyms

CEZANNE, ZA20D1
Links

HGNC:16683

NCBI Gene ID: 56957

neXtProt AC: NX_Q6GQQ9

UniProt: Q6GQQ9
Chr Location

1q21.2; chr1:149937812-150067653 (-) GRCh38

MGI Vertebrate Homology

Otud7b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: OTUD7B
Gene Tree

Otud7b

less

References

1 with disease annotations

less

Phenotype Summary

13 phenotypes from 3 alleles in 4 genetic backgrounds
27 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

27
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

16
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Otud7b
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

45 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit decreased body weight, tertiary lymphoid hyperplasia, increased stimulated B cell proliferation and survival and decreased susceptibility to C. rodentium infection.

less

All GO Annotations

45
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

11

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase otud7b

ZFIN otud7b

less

All Sequences

79
RefSeq

28
UniProt

3
CCDS

CCDS17629.1

Ensembl

ENSMUSG00000038495 (Evidence)
NCBI Gene

229603

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038495	Ensembl Gene Model \| MGI Sequence Detail	56608	C57BL/6J	± kb
transcript	ENSMUST00000035519	Ensembl \| MGI Sequence Detail	8043	Not Applicable
polypeptide	ENSMUSP00000046413	Ensembl \| MGI Sequence Detail	840	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000012084 OTU domain-containing protein 7B

(term hierarchy)
EC

3.4.19.12
InterPro Domains

IPR003323 OTU domain

IPR051346 OTU Domain-Containing Deubiquitinase

IPR009060 UBA-like superfamily

IPR002653 Zinc finger, A20-type
GlyGen

B2RUR8 1 site, 1 O-linked glycan (1 site)

less

All nucleic 12

cDNA 11

Other 1

Microarray probesets 6

less

MGI:1920219, MGI:1922172, MGI:2139730

Summaries

All 64

Diseases 1

Gene Ontology 12

Phenotypes 27
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:347611 Varner LR, et al., The deubiquitinase Otud7b suppresses cone photoreceptor degeneration in mouse models of retinal degenerative diseases. iScience. 2024 Apr 19;27(4):109380

TSS for Otud7b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr30678	Chr3:96011790-96011801 (+)	-43 bp
Tssr30679	Chr3:96011810-96011883 (+)	8 bp
Tssr30680	Chr3:96012128-96012139 (+)	295 bp
Tssr30681	Chr3:96015833-96015843 (+)	3,999 bp
Tssr30682	Chr3:96015846-96015878 (+)	4,023 bp
Tssr30683	Chr3:96015881-96015898 (+)	4,051 bp
Tssr30684	Chr3:96015900-96015924 (+)	4,073 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24