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Grhl3 Gene Detail
Summary
  • Symbol
    Grhl3
  • Name
    grainyhead like transcription factor 3
  • Synonyms
    ct, Get1, nmf231, Som
  • Feature Type
    protein coding gene
  • IDs
    MGI:2655333
    NCBI Gene: 230824
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:135269199-135300941 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 67.76 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    869 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2655333
 protein coding gene Chr4:135269199-135300943 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028946
 protein coding gene Chr4:137985516-138017228 (-)
A/J MGP_AJ_G0028905
 protein coding gene Chr4:132154255-132185955 (-)
AKR/J MGP_AKRJ_G0028857
 protein coding gene Chr4:135964197-135995934 (-)
BALB/cJ MGP_BALBcJ_G0028929
 protein coding gene Chr4:132814292-132847181 (-)
C3H/HeJ MGP_C3HHeJ_G0028643
 protein coding gene Chr4:136244335-136276060 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029370
 protein coding gene Chr4:142911592-142947672 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026641
 protein coding gene Chr4:125211625-125243237 (-)
CAST/EiJ MGP_CASTEiJ_G0028075
 protein coding gene Chr4:134364955-134402014 (-)
CBA/J MGP_CBAJ_G0028608
 protein coding gene Chr4:146817679-146849480 (-)
DBA/2J MGP_DBA2J_G0028757
 protein coding gene Chr4:132572082-132603921 (-)
FVB/NJ MGP_FVBNJ_G0028724
 protein coding gene Chr4:131493162-131524830 (-)
LP/J MGP_LPJ_G0028856
 protein coding gene Chr4:138089383-138121130 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028750
 protein coding gene Chr4:151126803-151159407 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029408
 protein coding gene Chr4:136407396-136439334 (-)
PWK/PhJ MGP_PWKPhJ_G0027795
 protein coding gene Chr4:129344079-129376026 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027621
 protein coding gene Chr4:132233096-132265020 (-)
WSB/EiJ MGP_WSBEiJ_G0028153
 protein coding gene Chr4:136585104-136618104 (-)



Homology
more
  • Human Ortholog
    GRHL3, grainyhead like transcription factor 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRHL3, grainyhead like transcription factor 3
  • Synonyms
    SOM, TFCP2L4, VWS2
  • Links
    NCBI Gene ID: 57822
    neXtProt AC: NX_Q8TE85
    UniProt: Q8TE85

  • Chr Location
    1p36.11; chr1:24199558-24364482 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Grhl3 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    61 phenotypes from 9 alleles in 17 genetic backgrounds
    42 phenotypes from multigenic genotypes
    1 images
    106 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for the variably penetrant curly-tail mutation (ct) show symptoms of cranial or spinal neural tube defects such as curly tails and/or spina bifida; homozygotes with more severe phenotypes display exencephaly and die in utero. Homozygous knockout mice show severe neural tube defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1067
  • Tissues
    226
  • cDNA Data
    9
  • Literature Summary
    52
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037188 Ensembl Gene Model | MGI Sequence Detail 31743 C57BL/6J ±  kb
    transcript ENSMUST00000105855 Ensembl | MGI Sequence Detail 2789 Not Applicable  
    polypeptide ENSMUSP00000101481 Ensembl | MGI Sequence Detail 603 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 11
      Primer pair 10
      Other 6

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-2211, MGI:2140331, MGI:88550
    References
    more
    • Summaries
      All 164
      Developmental Gene Expression 52
      Diseases 1
      Gene Ontology 17
      Phenotypes 106
    • Earliest
      J:264 Gruneberg H, Genetical studies on the skeleton of the mouse. VIII. Curly-tail. J Genet. 1954;52(1):52-67
    • Latest
      J:355461 Deng Z, et al., Single-cell transcriptomics reveals the cellular identity of a novel progenitor population crucial for murine neural tube closure. Heliyon. 2024 Sep 15;10(17):e37259
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory