Opalin MGI Mouse Gene Detail - MGI:2657025 - oligodendrocytic myelin paranodal and inner loop protein

Symbol

Opalin
Name

oligodendrocytic myelin paranodal and inner loop protein
Synonyms

Tmem10, Tmp10

Feature Type

protein coding gene
IDs

MGI:2657025
NCBI Gene: 226115
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr19:41050398-41065552 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 34.36 cM
Mapping Data

2 experiments

SNPs within 2kb

542 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2657025	protein coding gene	Chr19:41050149-41065552 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025119	protein coding gene	Chr19:40321782-40337796 (-)
A/J	MGP_AJ_G0025096	protein coding gene	Chr19:38384108-38398907 (-)
AKR/J	MGP_AKRJ_G0025064	protein coding gene	Chr19:39650416-39666479 (-)
BALB/cJ	MGP_BALBcJ_G0025090	protein coding gene	Chr19:38434776-38449445 (-)
C3H/HeJ	MGP_C3HHeJ_G0024850	protein coding gene	Chr19:39792882-39808066 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025534	protein coding gene	Chr19:41401548-41417015 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022947	protein coding gene	Chr19:37747601-37760912 (-)
CAST/EiJ	MGP_CASTEiJ_G0024315	protein coding gene	Chr19:39427291-39443928 (-)
CBA/J	MGP_CBAJ_G0024830	protein coding gene	Chr19:43414116-43432097 (-)
DBA/2J	MGP_DBA2J_G0024962	protein coding gene	Chr19:38246160-38260745 (-)
FVB/NJ	MGP_FVBNJ_G0024923	protein coding gene	Chr19:38000883-38015297 (-)
LP/J	MGP_LPJ_G0025048	protein coding gene	Chr19:40338361-40353415 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024954	protein coding gene	Chr19:43072797-43092498 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025591	protein coding gene	Chr19:39677363-39691710 (-)
PWK/PhJ	MGP_PWKPhJ_G0024065	protein coding gene	Chr19:38094511-38110103 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023868	protein coding gene	Chr19:38417831-38432878 (-)
WSB/EiJ	MGP_WSBEiJ_G0024385	protein coding gene	Chr19:39842943-39860405 (-)

Human Ortholog

OPALIN, oligodendrocytic myelin paranodal and inner loop protein

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

OPALIN, oligodendrocytic myelin paranodal and inner loop protein
Synonyms

HTMP10, TMEM10, TMP10
Links

HGNC:20707

NCBI Gene ID: 93377

neXtProt AC: NX_Q96PE5

UniProt: Q96PE5
Chr Location

10q24.1; chr10:96343221-96359365 (-) GRCh38

MGI Vertebrate Homology

Opalin stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: OPALIN
Gene Tree

Opalin

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
4 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Endonuclease-mediated

1
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

9 strains or lines available
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a knock-out allele show increased exploratory activity in a novel environment.

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All GO Annotations

7
GO References

5

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

785
Tissues

37
cDNA Data

6
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

32
RefSeq

2
UniProt

2
CCDS

CCDS37985.1

Ensembl

ENSMUSG00000050121 (Evidence)
NCBI Gene

226115

			Length	Strain/Species	Flank
genomic	226115	NCBI Gene Model \| MGI Sequence Detail	15155	C57BL/6J	± kb
transcript	NM_153520	RefSeq \| MGI Sequence Detail	2353	C57BL/6
polypeptide	Q7M750	UniProt \| EBI \| MGI Sequence Detail	143	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000011646 opalin

(term hierarchy)
InterPro Domains

IPR026609 Opalin
GlyGen

Q7M750 4 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 9

cDNA 6

Primer pair 3

Microarray probesets 1

Summaries

All 30

Developmental Gene Expression 7

Gene Ontology 5

Phenotypes 4
Earliest

J:74484 Nobile C, et al., Identification and characterization of a novel human brain-specific gene, homologous to S. scrofa tmp83.5, in the chromosome 10q24 critical region for temporal lobe epilepsy and spastic paraplegia. Gene. 2002 Jan 9;282(1-2):87-94
Latest

J:320720 Yu Z, et al., GATOR2 complex-mediated amino acid signaling regulates brain myelination. Proc Natl Acad Sci U S A. 2022 Jan 18;119(3):e2110917119

TSS for Opalin:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr159249	Chr19:41065545-41065557 (-)	1 bp
Tssr159248	Chr19:41065502-41065517 (-)	42 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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