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Ofcc1 Gene Detail
Summary
  • Symbol
    Ofcc1
  • Name
    orofacial cleft 1 candidate 1
  • Synonyms
    ojoplano, Opo
  • Feature Type
    protein coding gene
  • IDs
    MGI:2658851
    NCBI Gene: 218165
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr13:40155358-40514926 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 19.45 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    10439 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2658851
 protein coding gene Chr13:40155358-40529793 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020477
 protein coding gene Chr13:38408784-38707898 (-)
A/J MGP_AJ_G0020431
 protein coding gene Chr13:37155229-37438776 (-)
AKR/J MGP_AKRJ_G0020409
 protein coding gene Chr13:38150480-38445577 (-)
BALB/cJ MGP_BALBcJ_G0020427
 protein coding gene Chr13:37312227-37609393 (-)
C3H/HeJ MGP_C3HHeJ_G0020226
 protein coding gene Chr13:38027789-38321910 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020860
 protein coding gene Chr13:39644496-39948011 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018447
 protein coding gene Chr13:35291669-35572765 (-)
CAST/EiJ MGP_CASTEiJ_G0019741
 protein coding gene Chr13:37784097-38087938 (-)
CBA/J MGP_CBAJ_G0020187
 protein coding gene Chr13:41335997-41641679 (-)
DBA/2J MGP_DBA2J_G0020309
 protein coding gene Chr13:36716647-37000089 (-)
FVB/NJ MGP_FVBNJ_G0020288
 protein coding gene Chr13:36229450-36509416 (-)
LP/J MGP_LPJ_G0020384
 protein coding gene Chr13:38666774-38951517 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020317
 protein coding gene Chr13:41349298-41658191 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020903
 protein coding gene Chr13:37783439-38080850 (-)
PWK/PhJ MGP_PWKPhJ_G0019496
 protein coding gene Chr13:36782778-37080743 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019326
 protein coding gene Chr13:36389261-36717115 (-)
WSB/EiJ MGP_WSBEiJ_G0019803
 protein coding gene Chr13:38090422-38398093 (-)



Homology
more
  • Human Ortholog
    OFCC1, orofacial cleft 1 candidate 1 (pseudogene)
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OFCC1, orofacial cleft 1 candidate 1 (pseudogene)
  • Synonyms
    MRDS1, Opo
  • Links
    NCBI Gene ID: 266553
    UniProt: Q8IZS5

  • Chr Location
    6p24.3; chr6:9596297-10211608 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit normal skull morphology and normal behavior with in increase in gamma-glutamyl transpeptidase.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    830
  • Tissues
    50
  • cDNA Data
    2
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000047094 Ensembl Gene Model | MGI Sequence Detail 359569 C57BL/6J ±  kb
    transcript ENSMUST00000054635 Ensembl | MGI Sequence Detail 2816 Not Applicable  
    polypeptide ENSMUSP00000062217 Ensembl | MGI Sequence Detail 926 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR031390 Orofacial cleft 1 candidate gene 1 protein
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 2
      Primer pair 6

      Microarray probesets 1
    References
    more
    • Summaries
      All 21
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 8
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory