Cnksr2 MGI Mouse Gene Detail - MGI:2661175 - connector enhancer of kinase suppressor of Ras 2

Symbol

Cnksr2
Name

connector enhancer of kinase suppressor of Ras 2
Synonyms

Cnk2, Ksr2, mKIAA0902

Feature Type

protein coding gene
IDs

MGI:2661175
NCBI Gene: 245684
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

ChrX:156604432-156826290 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 72.76 cM
Mapping Data

1 experiment

SNPs within 2kb

4010 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2661175	protein coding gene	ChrX:156604426-156827454 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0036222	protein coding gene	ChrX:155712065-155950830 (-)
A/J	MGP_AJ_G0036192	protein coding gene	ChrX:155027526-155255340 (-)
AKR/J	MGP_AKRJ_G0036120	protein coding gene	ChrX:159923940-160156128 (-)
BALB/cJ	MGP_BALBcJ_G0036185	protein coding gene	ChrX:153083403-153307242 (-)
C3H/HeJ	MGP_C3HHeJ_G0035891	protein coding gene	ChrX:156071749-156313682 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0036707	protein coding gene	ChrX:160311812-160563383 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033528	protein coding gene	ChrX:146359801-146598164 (-)
CAST/EiJ	MGP_CASTEiJ_G0035179	protein coding gene	ChrX:135172241-135442636 (-)
CBA/J	MGP_CBAJ_G0035866	protein coding gene	ChrX:164894441-165143504 (-)
DBA/2J	MGP_DBA2J_G0036032	protein coding gene	ChrX:154000323-154224585 (-)
FVB/NJ	MGP_FVBNJ_G0035963	protein coding gene	ChrX:153097932-153338071 (-)
LP/J	MGP_LPJ_G0036117	protein coding gene	ChrX:156870526-157107115 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035995	protein coding gene	ChrX:173458637-173776804 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036748	protein coding gene	ChrX:155263537-155503217 (-)
PWK/PhJ	MGP_PWKPhJ_G0034877	protein coding gene	ChrX:132120710-132346401 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0034698	protein coding gene	ChrX:135644432-135864651 (-)
WSB/EiJ	MGP_WSBEiJ_G0035314	protein coding gene	ChrX:153256105-153486693 (-)

Human Ortholog

CNKSR2, connector enhancer of kinase suppressor of Ras 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CNKSR2, connector enhancer of kinase suppressor of Ras 2
Synonyms

CNK2, KSR2, MAGUIN, MRXSHG
Links

HGNC:19701

NCBI Gene ID: 22866

neXtProt AC: NX_Q8WXI2

UniProt: Q8WXI2
Chr Location

Xp22.12; chrX:21372801-21654695 (+) GRCh38

MGI Vertebrate Homology

Cnksr2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CNKSR2
Gene Tree

Cnksr2

Diseases

1 with human CNKSR2 associations

				Human Disease	Mouse Models
				syndromic X-linked mental retardation Hough type IDs syndromic X-linked mental retardation Hough type DOID:0080242 OMIM:301008

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

3
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

9 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

20
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

17

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cnksr2

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All Sequences

51
RefSeq

14
UniProt

3
CCDS

CCDS30501.1, CCDS90768.1

Ensembl

ENSMUSG00000025658 (Evidence)
NCBI Gene

245684

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025658	Ensembl Gene Model \| MGI Sequence Detail	221859	C57BL/6J	± kb
transcript	ENSMUST00000026750	Ensembl \| MGI Sequence Detail	5738	Not Applicable
polypeptide	ENSMUSP00000026750	Ensembl \| MGI Sequence Detail	1032	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000005638 connector enhancer of kinase suppressor of ras 2

(term hierarchy)
InterPro Domains

IPR049628 CNK1-3, SAM domain

IPR051566 Connector enhancer of kinase suppressor of Ras

IPR010599 Connector enhancer of kinase suppressor of ras 2/3 domain

IPR017874 CRIC domain

IPR001478 PDZ domain

IPR036034 PDZ superfamily

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR001660 Sterile alpha motif domain

IPR013761 Sterile alpha motif/pointed domain superfamily
GlyGen

Q80YA9 6 sites, 1 O-linked glycan (6 sites)

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All nucleic 17

cDNA 17

Microarray probesets 2

Summaries

All 34

Gene Ontology 8

Phenotypes 7
Earliest

J:83413 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Feb 28;10(1):35-48
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cnksr2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr164471	ChrX:156826401-156826421 (-)	-121 bp
Tssr164470	ChrX:156826262-156826282 (-)	18 bp
Tssr164469	ChrX:156826202-156826256 (-)	61 bp
Tssr5712	ChrX:156826126-156826135 (-)	159 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24