Neu4 MGI Mouse Gene Detail - MGI:2661364

Symbol

Neu4
Name

sialidase 4

Feature Type

protein coding gene
IDs

MGI:2661364
NCBI Gene: 241159
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr1:93948215-93956056 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 47.46 cM
Mapping Data

1 experiment

SNPs within 2kb

286 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2661364	protein coding gene	Chr1:93948173-93956056 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016352	protein coding gene	Chr1:95676837-95684718 (+)
A/J	MGP_AJ_G0016336	protein coding gene	Chr1:92283735-92291616 (+)
AKR/J	MGP_AKRJ_G0016297	protein coding gene	Chr1:95002180-95010062 (+)
BALB/cJ	MGP_BALBcJ_G0016292	protein coding gene	Chr1:92491271-92499152 (+)
C3H/HeJ	MGP_C3HHeJ_G0016118	protein coding gene	Chr1:95253716-95261597 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016751	protein coding gene	Chr1:99437155-99445037 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014469	protein coding gene	Chr1:86493650-86500564 (+)
CAST/EiJ	MGP_CASTEiJ_G0015701	protein coding gene	Chr1:94570761-94578649 (+)
CBA/J	MGP_CBAJ_G0016092	protein coding gene	Chr1:102581545-102589426 (+)
DBA/2J	MGP_DBA2J_G0016197	protein coding gene	Chr1:91505013-91512894 (+)
FVB/NJ	MGP_FVBNJ_G0016198	protein coding gene	Chr1:90573189-90581082 (+)
LP/J	MGP_LPJ_G0016271	protein coding gene	Chr1:96946483-96954364 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016224	protein coding gene	Chr1:105644058-105651939 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016790	protein coding gene	Chr1:95002632-95010513 (+)
PWK/PhJ	MGP_PWKPhJ_G0015489	protein coding gene	Chr1:90806042-90814043 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015273	protein coding gene	Chr1:93903796-93911950 (+)
WSB/EiJ	MGP_WSBEiJ_G0015764	protein coding gene	Chr1:94834990-94842835 (+)

Human Ortholog

NEU4, neuraminidase 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NEU4, neuraminidase 4
Links

HGNC:21328

NCBI Gene ID: 129807

neXtProt AC: NX_Q8WWR8

UniProt: Q8WWR8
Chr Location

2q37.3; chr2:241809065-241817413 (+) GRCh38

MGI Vertebrate Homology

Neu4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NEU4
Gene Tree

Neu4

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

5
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Neu4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele are largely normal except increased lipid content in the lung and liver and vacuolization indicative of lysosomal storage disorder.

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All GO Annotations

31
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

834
Tissues

107
cDNA Data

10
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase neu4

ZFIN neu4

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All Sequences

36
RefSeq

4
UniProt

2
CCDS

CCDS15199.1, CCDS78660.1

Ensembl

ENSMUSG00000034000 (Evidence)
NCBI Gene

241159

			Length	Strain/Species	Flank
genomic	241159	NCBI Gene Model \| MGI Sequence Detail	7842	C57BL/6J	± kb
transcript	NM_001310769	RefSeq \| MGI Sequence Detail	4608	C57BL/6
polypeptide	Q8BZL1	UniProt \| EBI \| MGI Sequence Detail	478	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000011148 sialidase-4

(term hierarchy)
EC

3.2.1.18
InterPro Domains

IPR011040 Sialidase

IPR026856 Sialidase family

IPR036278 Sialidase superfamily

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All nucleic 13

cDNA 10

Primer pair 3

Microarray probesets 1

Summaries

All 38

Developmental Gene Expression 4

Gene Ontology 8

Phenotypes 15
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:329415 Howlader MA, et al., The Janus-like role of neuraminidase isoenzymes in inflammation. FASEB J. 2022 May;36(5):e22285

TSS for Neu4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8210	Chr1:93948181-93948207 (+)	-21 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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