Snx13 MGI Mouse Gene Detail - MGI:2661416

Symbol

Snx13
Name

sorting nexin 13
Synonyms

mKIAA0713, RGS-PX1

Feature Type

protein coding gene
IDs

MGI:2661416
NCBI Gene: 217463
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr12:35097191-35197479 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 15.67 cM
Mapping Data

1 experiment

SNPs within 2kb

2276 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2661416	protein coding gene	Chr12:35097185-35197479 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019683	protein coding gene	Chr12:33208329-33310652 (+)
A/J	MGP_AJ_G0019649	protein coding gene	Chr12:32196454-32298370 (+)
AKR/J	MGP_AKRJ_G0019620	protein coding gene	Chr12:33195496-33292928 (+)
BALB/cJ	MGP_BALBcJ_G0019627	protein coding gene	Chr12:32382667-32489237 (+)
C3H/HeJ	MGP_C3HHeJ_G0019431	protein coding gene	Chr12:33101813-33220632 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020074	protein coding gene	Chr12:34165804-34271480 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017699	protein coding gene	Chr12:31351545-31447454 (+)
CAST/EiJ	MGP_CASTEiJ_G0018985	protein coding gene	Chr12:28154501-28263672 (+)
CBA/J	MGP_CBAJ_G0019403	protein coding gene	Chr12:35274263-35396354 (+)
DBA/2J	MGP_DBA2J_G0019516	protein coding gene	Chr12:32020269-32125476 (+)
FVB/NJ	MGP_FVBNJ_G0019505	protein coding gene	Chr12:31750470-31852809 (+)
LP/J	MGP_LPJ_G0019586	protein coding gene	Chr12:33275881-33377576 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019541	protein coding gene	Chr12:34983244-35088238 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020114	protein coding gene	Chr12:32699475-32801375 (+)
PWK/PhJ	MGP_PWKPhJ_G0018752	protein coding gene	Chr12:26740421-26841874 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018541	protein coding gene	Chr12:27368716-27462880 (+)
WSB/EiJ	MGP_WSBEiJ_G0019035	protein coding gene	Chr12:32956947-33061893 (+)

Human Ortholog

SNX13, sorting nexin 13

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SNX13, sorting nexin 13
Synonyms

RGS-PX1
Links

HGNC:21335

NCBI Gene ID: 23161

neXtProt AC: NX_Q9Y5W8

UniProt: Q9Y5W8
Chr Location

7p21.1; chr7:17790761-17940501 (-) GRCh38

MGI Vertebrate Homology

Snx13 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SNX13
Gene Tree

Snx13

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Phenotype Summary

15 phenotypes from 2 alleles in 2 genetic backgrounds
2 images
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

53 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice are growth retarded and die at midgestation with defects in neural tube closure, vasculogenesis and placental development. Mutant visceral yolk sac endoderm cells exhibit altered endocytic compartments, abundant autophagic vacuoles and mislocalization of endocytic markers.

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All GO Annotations

10
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

710
Tissues

1
cDNA Data

71
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase snx13

ZFIN snx13

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All Sequences

92
RefSeq

33
UniProt

10
CCDS

CCDS56837.1

Ensembl

ENSMUSG00000020590 (Evidence)
NCBI Gene

217463

			Length	Strain/Species	Flank
genomic	217463	NCBI Gene Model \| MGI Sequence Detail	100289	C57BL/6J	± kb
transcript	NM_001408821	RefSeq \| MGI Sequence Detail	6461	C57BL/6
polypeptide	Q6PHS6	UniProt \| EBI \| MGI Sequence Detail	957	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000015362 sorting nexin-13

(term hierarchy)
InterPro Domains

IPR003114 Phox-associated domain

IPR001683 Phox homology

IPR036871 PX domain superfamily

IPR016137 RGS domain

IPR036305 RGS domain superfamily

IPR044926 RGS, subdomain 2

IPR037896 SNX13, RGS domain

IPR037437 Sorting nexin-13, PX domain

IPR013937 Sorting nexin, C-terminal
GlyGen

Q6PHS6 1 site, 1 N-linked glycan (1 site)

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All nucleic 72

cDNA 71

Primer pair 1

Microarray probesets 6

Summaries

All 28

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 6
Earliest

J:83413 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Feb 28;10(1):35-48
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Snx13:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr113215	Chr12:35097179-35097229 (+)	13 bp
Tssr113216	Chr12:35097251-35097262 (+)	66 bp
Tssr113217	Chr12:35100992-35100998 (+)	3,804 bp
Tssr113218	Chr12:35147692-35147719 (+)	50,515 bp
Tssr113219	Chr12:35185985-35186004 (+)	88,804 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24