Mgat4a MGI Mouse Gene Detail - MGI:2662992 - mannoside acetylglucosaminyltransferase 4, isoenzyme A

Symbol

Mgat4a
Name

mannoside acetylglucosaminyltransferase 4, isoenzyme A
Synonyms

9530018I07Rik, GnT-IVa

Feature Type

protein coding gene
IDs

MGI:2662992
NCBI Gene: 269181
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr1:37478421-37580097 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 15.46 cM
Mapping Data

2 experiments

SNPs within 2kb

2821 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2662992	protein coding gene	Chr1:37478421-37580599 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0015939	protein coding gene	Chr1:36063947-36174213 (-)
A/J	MGP_AJ_G0015923	protein coding gene	Chr1:35067225-35168483 (-)
AKR/J	MGP_AKRJ_G0015878	protein coding gene	Chr1:35556223-35664941 (-)
BALB/cJ	MGP_BALBcJ_G0015877	protein coding gene	Chr1:34743983-34841504 (-)
C3H/HeJ	MGP_C3HHeJ_G0015710	protein coding gene	Chr1:35786454-35898449 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016330	protein coding gene	Chr1:37645631-37754991 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014052	protein coding gene	Chr1:32083543-32182800 (-)
CAST/EiJ	MGP_CASTEiJ_G0015291	protein coding gene	Chr1:35639043-35755335 (-)
CBA/J	MGP_CBAJ_G0015682	protein coding gene	Chr1:38661668-38782656 (-)
DBA/2J	MGP_DBA2J_G0015783	protein coding gene	Chr1:34390150-34491599 (-)
FVB/NJ	MGP_FVBNJ_G0015785	protein coding gene	Chr1:33923903-34021574 (-)
LP/J	MGP_LPJ_G0015853	protein coding gene	Chr1:36402168-36504052 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015805	protein coding gene	Chr1:40862086-40966966 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016377	protein coding gene	Chr1:35622671-35727638 (-)
PWK/PhJ	MGP_PWKPhJ_G0015074	protein coding gene	Chr1:34154223-34261398 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0014856	protein coding gene	Chr1:35557364-35668159 (-)
WSB/EiJ	MGP_WSBEiJ_G0015353	protein coding gene	Chr1:35574473-35680242 (-)

Human Ortholog

MGAT4A, alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MGAT4A, alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A
Synonyms

GnT-4a, GNT-IV, GNT-IVA
Links

HGNC:7047

NCBI Gene ID: 11320

neXtProt AC: NX_Q9UM21

UniProt: Q9UM21
Chr Location

2q11.2; chr2:98619106-98731132 (-) GRCh38

MGI Vertebrate Homology

Mgat4a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MGAT4A
Gene Tree

Mgat4a

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Phenotype Summary

12 phenotypes from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

2
Targeted

2
Genomic Mutations

1 involving Mgat4a
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

34 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele show defects in glucose-stimulated insulin secretion, impaired cellular glucose import, increased susceptibility to weight gain, hyperglycemia, impaired glucose tolerance, insulin resistance, high free fatty acid and triglyceride levels, and hepatic steatosis.

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All GO Annotations

19
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

94
cDNA Data

12
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mgat4a

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All Sequences

83
RefSeq

30
UniProt

4
CCDS

CCDS14893.1, CCDS69882.1

Ensembl

ENSMUSG00000026110 (Evidence)
NCBI Gene

269181

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026110	Ensembl Gene Model \| MGI Sequence Detail	101677	C57BL/6J	± kb
transcript	ENSMUST00000151952	Ensembl \| MGI Sequence Detail	7251	Not Applicable
polypeptide	ENSMUSP00000114175	Ensembl \| MGI Sequence Detail	535	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000010381 alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A

(term hierarchy)
PDB

7VMT
EC

2.4.1.145
InterPro Domains

IPR006759 Glycosyl transferase family 54
GlyGen

Q812G0 2 sites

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All nucleic 13

cDNA 12

Primer pair 1

Microarray probesets 5

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MGI:2443457

Summaries

All 36

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 9
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:217242 Kurimoto A, et al., The absence of core fucose up-regulates GnT-III and Wnt target genes: a possible mechanism for an adaptive response in terms of glycan function. J Biol Chem. 2014 Apr 25;289(17):11704-14

TSS for Mgat4a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr11309	Chr1:37580084-37580127 (-)	-9 bp
Tssr11308	Chr1:37580061-37580073 (-)	30 bp
Tssr11307	Chr1:37575313-37575317 (-)	4,782 bp
Tssr11306	Chr1:37558265-37558280 (-)	21,824 bp
Tssr11305	Chr1:37535203-37535237 (-)	44,877 bp
Tssr11304	Chr1:37535170-37535187 (-)	44,918 bp
Tssr11302	Chr1:37514536-37514539 (-)	65,559 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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