Il22ra1 MGI Mouse Gene Detail - MGI:2663588 - interleukin 22 receptor, alpha 1

Symbol

Il22ra1
Name

interleukin 22 receptor, alpha 1
Synonyms

Il22r

Feature Type

protein coding gene
IDs

MGI:2663588
NCBI Gene: 230828
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr4:135455483-135479451 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 67.99 cM
Mapping Data

1 experiment

SNPs within 2kb

869 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2663588	protein coding gene	Chr4:135455470-135482694 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028948	protein coding gene	Chr4:138191892-138216214 (+)
A/J	MGP_AJ_G0028907	protein coding gene	Chr4:132342543-132366496 (+)
AKR/J	MGP_AKRJ_G0028859	protein coding gene	Chr4:136159428-136183484 (+)
BALB/cJ	MGP_BALBcJ_G0028931	protein coding gene	Chr4:133002192-133026146 (+)
C3H/HeJ	MGP_C3HHeJ_G0028645	protein coding gene	Chr4:136429145-136454397 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029372	protein coding gene	Chr4:143112890-143138814 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026643	protein coding gene	Chr4:125395924-125420049 (+)
CAST/EiJ	MGP_CASTEiJ_G0028077	protein coding gene	Chr4:134558808-134585670 (+)
CBA/J	MGP_CBAJ_G0028610	protein coding gene	Chr4:147032924-147056979 (+)
DBA/2J	MGP_DBA2J_G0028759	protein coding gene	Chr4:132757319-132781337 (+)
FVB/NJ	MGP_FVBNJ_G0028726	protein coding gene	Chr4:131683887-131707839 (+)
LP/J	MGP_LPJ_G0028858	protein coding gene	Chr4:138288588-138312918 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028752	protein coding gene	Chr4:151326306-151350242 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029410	protein coding gene	Chr4:136611013-136637546 (+)
PWK/PhJ	MGP_PWKPhJ_G0027797	protein coding gene	Chr4:129535448-129559622 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027623	protein coding gene	Chr4:132430922-132455010 (+)
WSB/EiJ	MGP_WSBEiJ_G0028155	protein coding gene	Chr4:136779284-136805885 (+)

Human Ortholog

IL22RA1, interleukin 22 receptor subunit alpha 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IL22RA1, interleukin 22 receptor subunit alpha 1
Synonyms

CRF2-9, IL22R, IL22R1
Links

HGNC:13700

NCBI Gene ID: 58985

neXtProt AC: NX_Q8N6P7

UniProt: Q8N6P7
Chr Location

1p36.11; chr1:24119771-24143140 (-) GRCh38

MGI Vertebrate Homology

Il22ra1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: IL22RA1
Gene Tree

Il22ra1

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Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
5 phenotypes from multigenic genotypes
29 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

1
Targeted

8
Genomic Mutations

3 involving Il22ra1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

9
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

718
Tissues

5
cDNA Data

9
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase il22ra1

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All Sequences

31
RefSeq

2
UniProt

2
CCDS

CCDS18789.1

Ensembl

ENSMUSG00000037157 (Evidence)
NCBI Gene

230828

			Length	Strain/Species	Flank
genomic	ENSMUSG00000037157	Ensembl Gene Model \| MGI Sequence Detail	23969	C57BL/6J	± kb
transcript	ENSMUST00000102546	Ensembl \| MGI Sequence Detail	2569	Not Applicable
polypeptide	ENSMUSP00000099605	Ensembl \| MGI Sequence Detail	581	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008999 interleukin-22 receptor subunit alpha-1

(term hierarchy)
PDB

6WEO
InterPro Domains

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR013783 Immunoglobulin-like fold

IPR050650 Type II Cytokine and Tissue Factor Receptors
GlyGen

Q80XZ4 2 sites

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All nucleic 12

Genomic 1

cDNA 9

Primer pair 2

Microarray probesets 1

Summaries

All 54

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 29
Earliest

J:338066 Parrish-Novak J, et al., Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions. J Biol Chem. 2002 Dec 6;277(49):47517-23
Latest

J:350362 Sajiir H, et al., Pancreatic beta-cell IL-22 receptor deficiency induces age-dependent dysregulation of insulin biosynthesis and systemic glucose homeostasis. Nat Commun. 2024 May 29;15(1):4527

TSS for Il22ra1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr39632	Chr4:135455427-135455501 (+)	-19 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24