Slc16a11 MGI Mouse Gene Detail - MGI:2663709 - solute carrier family 16 (monocarboxylic acid transporters), member 11

Symbol

Slc16a11
Name

solute carrier family 16 (monocarboxylic acid transporters), member 11
Synonyms

MNCb-2717

Feature Type

protein coding gene
IDs

MGI:2663709
NCBI Gene: 216867
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr11:70104717-70107239 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 42.99 cM
Mapping Data

1 experiment

SNPs within 2kb

42 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2663709	protein coding gene	Chr11:70103578-70107243 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018584	protein coding gene	Chr11:70733291-70736956 (+)
A/J	MGP_AJ_G0018552	protein coding gene	Chr11:68044607-68048272 (+)
AKR/J	MGP_AKRJ_G0018521	protein coding gene	Chr11:70075088-70078753 (+)
BALB/cJ	MGP_BALBcJ_G0018524	protein coding gene	Chr11:68367385-68371050 (+)
C3H/HeJ	MGP_C3HHeJ_G0018337	protein coding gene	Chr11:70113418-70117083 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018975	protein coding gene	Chr11:72831359-72835024 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016620	protein coding gene	Chr11:64962884-64966533 (+)
CAST/EiJ	MGP_CASTEiJ_G0017892	protein coding gene	Chr11:70358829-70362488 (+)
CBA/J	MGP_CBAJ_G0018309	protein coding gene	Chr11:76139519-76143184 (+)
DBA/2J	MGP_DBA2J_G0018419	protein coding gene	Chr11:67620332-67623994 (+)
FVB/NJ	MGP_FVBNJ_G0018409	protein coding gene	Chr11:67275852-67279517 (+)
LP/J	MGP_LPJ_G0018489	protein coding gene	Chr11:71302973-71306638 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018432	protein coding gene	Chr11:76708668-76712333 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019017	protein coding gene	Chr11:70346891-70350556 (+)
PWK/PhJ	MGP_PWKPhJ_G0017666	protein coding gene	Chr11:68273672-68277399 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017456	protein coding gene	Chr11:70144282-70147969 (+)
WSB/EiJ	MGP_WSBEiJ_G0017946	protein coding gene	Chr11:70009784-70013444 (+)

Human Ortholog

SLC16A11, solute carrier family 16 member 11

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC16A11, solute carrier family 16 member 11
Synonyms

MCT 11, MCT11
Links

HGNC:23093

NCBI Gene ID: 162515

neXtProt AC: NX_Q8NCK7

UniProt: Q8NCK7
Chr Location

17p13.1; chr17:7041621-7044092 (-) GRCh38

MGI Vertebrate Homology

Slc16a11 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC16A11
Gene Tree

Slc16a11

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
19 phenotype references

All Mutations and Alleles

16
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

7
Targeted

5
Transgenic

1
Genomic Mutations

3 involving Slc16a11
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

18 strains or lines available

Homozygous null mice show no significant metabolic defects.

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All GO Annotations

12
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

707
Tissues

1
cDNA Data

9
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

57
RefSeq

6
UniProt

6
CCDS

CCDS36203.1

Ensembl

ENSMUSG00000040938 (Evidence)
NCBI Gene

216867

			Length	Strain/Species	Flank
genomic	216867	NCBI Gene Model \| MGI Sequence Detail	2523	C57BL/6J	± kb
transcript	NM_001416062	RefSeq \| MGI Sequence Detail	1680	C57BL/6
polypeptide	Q5NC32	UniProt \| EBI \| MGI Sequence Detail	447	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000014946 monocarboxylate transporter 11

(term hierarchy)
InterPro Domains

IPR011701 Major facilitator superfamily

IPR020846 Major facilitator superfamily domain

IPR036259 MFS transporter superfamily

IPR050327 Proton-linked Monocarboxylate Transporter

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All nucleic 10

cDNA 9

Primer pair 1

Microarray probesets 3

Summaries

All 42

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 19
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:348785 Zhang D, et al., Maternal Ezh1/2 deficiency impairs the function of mitochondria in mouse oocytes and early embryos. J Cell Physiol. 2024 Mar 26;

TSS for Slc16a11:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102666	Chr11:70104749-70104770 (+)	43 bp
Tssr102667	Chr11:70104931-70104958 (+)	228 bp
Tssr102668	Chr11:70104962-70104988 (+)	258 bp
Tssr102669	Chr11:70105779-70105790 (+)	1,068 bp
Tssr102670	Chr11:70105800-70105808 (+)	1,087 bp
Tssr3567	Chr11:70105808-70105818 (+)	1,096 bp
Tssr102671	Chr11:70105838-70105845 (+)	1,125 bp
Tssr102672	Chr11:70105847-70105852 (+)	1,133 bp
Tssr102673	Chr11:70105856-70105884 (+)	1,153 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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