Cnga4 MGI Mouse Gene Detail - MGI:2664099 - cyclic nucleotide gated channel alpha 4

Symbol

Cnga4
Name

cyclic nucleotide gated channel alpha 4

Feature Type

protein coding gene
IDs

MGI:2664099
NCBI Gene: 233649
Alliance

gene page

Sequence Map

Chr7:105053775-105057949 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 55.85 cM
Mapping Data

1 experiment

SNPs within 2kb

213 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2664099	protein coding gene	Chr7:105049247-105057981 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032751	protein coding gene	Chr7:108648568-108652738 (+)
A/J	MGP_AJ_G0032731	protein coding gene	Chr7:105811591-105815761 (+)
AKR/J	MGP_AKRJ_G0032664	protein coding gene	Chr7:108574815-108581686 (+)
BALB/cJ	MGP_BALBcJ_G0032737	protein coding gene	Chr7:105528197-105532367 (+)
C3H/HeJ	MGP_C3HHeJ_G0032446	protein coding gene	Chr7:108673407-108677577 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033242	protein coding gene	Chr7:112965456-112969626 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030226	protein coding gene	Chr7:107790514-107794695 (+)
CAST/EiJ	MGP_CASTEiJ_G0031776	protein coding gene	Chr7:100496533-100501439 (+)
CBA/J	MGP_CBAJ_G0032420	protein coding gene	Chr7:116746424-116750594 (+)
DBA/2J	MGP_DBA2J_G0032573	protein coding gene	Chr7:104082515-104086685 (+)
FVB/NJ	MGP_FVBNJ_G0032526	protein coding gene	Chr7:103888240-103892411 (+)
LP/J	MGP_LPJ_G0032664	protein coding gene	Chr7:110052322-110056492 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032558	protein coding gene	Chr7:118355535-118359705 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033263	protein coding gene	Chr7:107624839-107629010 (+)
PWK/PhJ	MGP_PWKPhJ_G0031489	protein coding gene	Chr7:97009408-97018256 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031338	protein coding gene	Chr7:94743031-94747211 (+)
WSB/EiJ	MGP_WSBEiJ_G0031893	protein coding gene	Chr7:108268408-108272579 (+)

Human Ortholog

CNGA4, cyclic nucleotide gated channel subunit alpha 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CNGA4, cyclic nucleotide gated channel subunit alpha 4
Synonyms

CNCA2, CNG-4, CNG4, CNG5, CNGB2, OCNC2, OCNCb, OCNCBETA
Links

HGNC:2152

NCBI Gene ID: 1262

neXtProt AC: NX_Q8IV77

UniProt: Q8IV77
Chr Location

11p15.4; chr11:6234765-6244976 (+) GRCh38

MGI Vertebrate Homology

Cnga4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CNGA4
Gene Tree

Cnga4

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Cnga4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

34 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Inactivation of this gene results in odor adaptation defects.

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All GO Annotations

23
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

6

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cnga4

ZFIN cnga4

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All Sequences

36
RefSeq

6
UniProt

1
CCDS

CCDS21650.1

Ensembl

ENSMUSG00000030897 (Evidence)
NCBI Gene

233649

			Length	Strain/Species	Flank
genomic	ENSMUSG00000030897	Ensembl Gene Model \| MGI Sequence Detail	4175	C57BL/6J	± kb
transcript	ENSMUST00000033187	Ensembl \| MGI Sequence Detail	2484	Not Applicable
polypeptide	ENSMUSP00000033187	Ensembl \| MGI Sequence Detail	575	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000005631 cyclic nucleotide-gated cation channel alpha-4

(term hierarchy)
InterPro Domains

IPR018488 Cyclic nucleotide-binding, conserved site

IPR000595 Cyclic nucleotide-binding domain

IPR018490 Cyclic nucleotide-binding domain superfamily

IPR050866 Cyclic Nucleotide-Gated Cation Channel

IPR032406 Cyclic nucleotide-gated channel, C-terminal leucine zipper domain

IPR005821 Ion transport domain

IPR014710 RmlC-like jelly roll fold

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All nucleic 8

Genomic 2

cDNA 6

Microarray probesets 2

Summaries

All 40

Gene Ontology 9

Phenotypes 14
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:179991 Cisneros-Mejorado A, et al., cGMP and cyclic nucleotide-gated channels participate in mouse sperm capacitation. FEBS Lett. 2012 Jan 20;586(2):149-53

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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