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Tnn Gene Detail
Summary
  • Symbol
    Tnn
  • Name
    tenascin N
  • Synonyms
    tenascin-W, Tnw
  • Feature Type
    protein coding gene
  • IDs
    MGI:2665790
    NCBI Gene: 329278
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:159912599-159981150 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 69.40 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1824 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2665790
 protein coding gene Chr1:159912599-159981242 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016640
 protein coding gene Chr1:165258363-165341678 (-)
A/J MGP_AJ_G0016621
 protein coding gene Chr1:158561723-158631446 (-)
AKR/J MGP_AKRJ_G0016587
 protein coding gene Chr1:163409153-163479275 (-)
BALB/cJ MGP_BALBcJ_G0016582
 protein coding gene Chr1:159111686-159181819 (-)
C3H/HeJ MGP_C3HHeJ_G0016406
 protein coding gene Chr1:163564131-163649776 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017043
 protein coding gene Chr1:170877208-170947626 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014752
 protein coding gene Chr1:150717820-150784982 (-)
CAST/EiJ MGP_CASTEiJ_G0015986
 protein coding gene Chr1:163199430-163272466 (-)
CBA/J MGP_CBAJ_G0016381
 protein coding gene Chr1:176929607-177009536 (-)
DBA/2J MGP_DBA2J_G0016487
 protein coding gene Chr1:157536925-157607098 (-)
FVB/NJ MGP_FVBNJ_G0016485
 protein coding gene Chr1:155947027-156015185 (-)
LP/J MGP_LPJ_G0016558
 protein coding gene Chr1:166369988-166444118 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016510
 protein coding gene Chr1:184439882-184513849 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017079
 protein coding gene Chr1:163213979-163293519 (-)
PWK/PhJ MGP_PWKPhJ_G0015772
 protein coding gene Chr1:156680004-156750704 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015559
 protein coding gene Chr1:162063786-162131062 (-)
WSB/EiJ MGP_WSBEiJ_G0016048
 protein coding gene Chr1:163390403-163463149 (-)



Homology
more
  • Human Ortholog
    TNN, tenascin N
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNN, tenascin N
  • Synonyms
    TN-W, TNW
  • Links
    NCBI Gene ID: 63923
    neXtProt AC: NX_Q9UQP3
    UniProt: Q9UQP3

  • Chr Location
    1q25.1; chr1:175067833-175148075 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced food intake, body weight and lifespan, and major defects in the alveolar bone and periodontal ligament of growing incisors while molars remain unaffected.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    757
  • Tissues
    33
  • cDNA Data
    10
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026725 Ensembl Gene Model | MGI Sequence Detail 68552 C57BL/6J ±  kb
    transcript ENSMUST00000039178 Ensembl | MGI Sequence Detail 5817 Not Applicable  
    polypeptide ENSMUSP00000039452 Ensembl | MGI Sequence Detail 1560 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 10
      Primer pair 3
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 10
      Gene Ontology 8
      Phenotypes 11
    • Earliest
      J:83982 Neidhardt J, et al., Tenascin-N: characterization of a novel member of the tenascin family that mediates neurite repulsion from hippocampal explants. Mol Cell Neurosci. 2003 Jun;23(2):193-209
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory