Serpinb6d MGI Mouse Gene Detail - MGI:2667783 - serine (or cysteine) peptidase inhibitor, clade B, member 6d

Symbol

Serpinb6d
Name

serine (or cysteine) peptidase inhibitor, clade B, member 6d
Synonyms

Gm11390, SPI3D

Feature Type

protein coding gene
IDs

MGI:2667783
NCBI Gene: 238568
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr13:33845388-33855564 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 13.94 cM
Mapping Data

1 experiment

SNPs within 2kb

302 from dbSNP Build 142
Strain Annotations

16

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2667783	protein coding gene	Chr13:33845388-33855568 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020440	protein coding gene	Chr13:31789569-31804672 (+)
A/J	MGP_AJ_G0020395	protein coding gene	Chr13:30864145-30875572 (+)
AKR/J	MGP_AKRJ_G0020372	protein coding gene	Chr13:31547759-31567435 (+)
BALB/cJ	MGP_BALBcJ_G0020390	protein coding gene	Chr13:30922415-30932870 (+)
C3H/HeJ	MGP_C3HHeJ_G0020189	protein coding gene	Chr13:31493780-31503912 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020824	protein coding gene	Chr13:32822808-32834554 (+)
CAROLI/EiJ	no annotation
CAST/EiJ	MGP_CASTEiJ_G0019705	protein coding gene	Chr13:31199538-31209836 (+)
CBA/J	MGP_CBAJ_G0020149	protein coding gene	Chr13:34254767-34264975 (+)
DBA/2J	MGP_DBA2J_G0020271	protein coding gene	Chr13:30345008-30357113 (+)
FVB/NJ	MGP_FVBNJ_G0020251	protein coding gene	Chr13:29944321-29954494 (+)
LP/J	MGP_LPJ_G0020347	protein coding gene	Chr13:32002581-32020330 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020282	protein coding gene	Chr13:34465823-34478483 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020867	protein coding gene	Chr13:31228805-31239893 (+)
PWK/PhJ	no annotation
SPRET/EiJ	MGP_SPRETEiJ_G0019285	protein coding gene	Chr13:29960167-29970158 (+)
WSB/EiJ	MGP_WSBEiJ_G0019767	protein coding gene	Chr13:31577278-31588843 (+)

Human Ortholog

SERPINB6, serpin family B member 6

Vertebrate Orthologs

6

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SERPINB6, serpin family B member 6
Synonyms

CAP, DFNB91, MSTP057, PI-6, PI6, PTI, SPI3
Links

HGNC:8950

NCBI Gene ID: 5269

neXtProt AC: NX_P35237

UniProt: P35237
Chr Location

6p25.2; chr6:2948159-2972165 (-) GRCh38

MGI Vertebrate Homology

Serpinb6d stringent orthology
1 human;1 mouse;5 zebrafish
HCOP

vertebrate homology predictions: SERPINB6
Gene Tree

Serpinb6d

Diseases

1 with human SERPINB6 associations

				Human Disease	Mouse Models
				autosomal recessive nonsyndromic deafness 91 IDs autosomal recessive nonsyndromic deafness 91 DOID:0110536 ICD10CM:H90.3 OMIM:613453

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

10 phenotype references

All Mutations and Alleles

4
Chemically induced (other)

1
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Serpinb6d
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

34 strains or lines available

less

All GO Annotations

10
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

710
Tissues

4
cDNA Data

2
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

less

All Sequences

30
RefSeq

4
UniProt

1
CCDS

CCDS36631.1

Ensembl

ENSMUSG00000047889 (Evidence)
NCBI Gene

238568

			Length	Strain/Species	Flank
genomic	ENSMUSG00000047889	Ensembl Gene Model \| MGI Sequence Detail	10177	C57BL/6J	± kb
transcript	ENSMUST00000059637	Ensembl \| MGI Sequence Detail	1463	Not Applicable
polypeptide	ENSMUSP00000063025	Ensembl \| MGI Sequence Detail	375	Not Applicable

less

UniProt

1 Sequence
InterPro Domains

IPR023795 Serpin, conserved site

IPR023796 Serpin domain

IPR000215 Serpin family

IPR036186 Serpin superfamily

IPR042178 Serpin superfamily, domain 1

IPR042185 Serpin superfamily, domain 2

less

All nucleic 4

Genomic 1

cDNA 2

Primer pair 1

Microarray probesets 1

less

MGI:3649829

Summaries

All 24

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 10
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Serpinb6d:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119194	Chr13:33845385-33845389 (+)	-1 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24