Wfikkn2 MGI Mouse Gene Detail - MGI:2669209 - WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2

Symbol

Wfikkn2
Name

WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
Synonyms

2610304F08Rik, Gasp1

Feature Type

protein coding gene
IDs

MGI:2669209
NCBI Gene: 278507
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:94126782-94136831 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 58.90 cM, cytoband C
Mapping Data

2 experiments

SNPs within 2kb

390 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2669209	protein coding gene	Chr11:94126777-94138613 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018951	protein coding gene	Chr11:96303907-96315508 (-)
A/J	MGP_AJ_G0018919	protein coding gene	Chr11:92464834-92474381 (-)
AKR/J	MGP_AKRJ_G0018889	protein coding gene	Chr11:95338169-95348312 (-)
BALB/cJ	MGP_BALBcJ_G0018892	protein coding gene	Chr11:92899566-92910406 (-)
C3H/HeJ	MGP_C3HHeJ_G0018706	protein coding gene	Chr11:95418923-95429380 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019344	protein coding gene	Chr11:99305364-99314845 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016975	protein coding gene	Chr11:89959162-89969512 (-)
CAST/EiJ	MGP_CASTEiJ_G0018261	protein coding gene	Chr11:96119666-96131723 (-)
CBA/J	MGP_CBAJ_G0018677	protein coding gene	Chr11:103412831-103429529 (-)
DBA/2J	MGP_DBA2J_G0018785	protein coding gene	Chr11:92040472-92050005 (-)
FVB/NJ	MGP_FVBNJ_G0018774	protein coding gene	Chr11:91456622-91466687 (-)
LP/J	MGP_LPJ_G0018855	protein coding gene	Chr11:96847260-96862024 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018801	protein coding gene	Chr11:103470218-103481046 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019384	protein coding gene	Chr11:95555950-95565767 (-)
PWK/PhJ	MGP_PWKPhJ_G0018031	protein coding gene	Chr11:92944084-92975653 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017821	protein coding gene	Chr11:95226339-95235824 (-)
WSB/EiJ	MGP_WSBEiJ_G0018310	protein coding gene	Chr11:95436610-95447665 (-)

Human Ortholog

WFIKKN2, WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

WFIKKN2, WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
Synonyms

GASP-1, hGASP-1, WFDC20B, WFIKKNRP
Links

HGNC:30916

NCBI Gene ID: 124857

neXtProt AC: NX_Q8TEU8

UniProt: Q8TEU8
Chr Location

17q21.33; chr17:50834584-50842353 (+) GRCh38

MGI Vertebrate Homology

Wfikkn2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: WFIKKN2
Gene Tree

Wfikkn2

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References

1 with disease annotations

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
8 phenotypes from multigenic genotypes
3 images
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

1
Gene trapped

1
Targeted

8
Genomic Mutations

3 involving Wfikkn2
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation show impaired muscle regeneration and a mild decrease in skeletal muscle weight in males.

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All GO Annotations

22
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

757
Tissues

23
cDNA Data

13
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN wfikkn2a, wfikkn2b

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All Sequences

48
RefSeq

16
UniProt

4
CCDS

CCDS25251.1

Ensembl

ENSMUSG00000044177 (Evidence)
NCBI Gene

278507

			Length	Strain/Species	Flank
genomic	ENSMUSG00000044177	Ensembl Gene Model \| MGI Sequence Detail	10050	C57BL/6J	± kb
transcript	ENSMUST00000061469	Ensembl \| MGI Sequence Detail	3516	Not Applicable
polypeptide	ENSMUSP00000053238	Ensembl \| MGI Sequence Detail	571	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000017413 WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2

(term hierarchy)
PDB

6MAA
InterPro Domains

IPR036645 Elafin-like superfamily

IPR013098 Immunoglobulin I-set

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR002350 Kazal domain

IPR036058 Kazal domain superfamily

IPR001134 Netrin domain

IPR018933 Netrin module, non-TIMP type

IPR002223 Pancreatic trypsin inhibitor Kunitz domain

IPR036880 Pancreatic trypsin inhibitor Kunitz domain superfamily

IPR020901 Proteinase inhibitor I2, Kunitz, conserved site

IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold

IPR008197 WAP-type 'four-disulfide core' domain

IPR033638 WFIKKN1/2, immunoglobulin-like domain 3
GlyGen

Q7TQN3 2 sites

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All nucleic 17

cDNA 13

Primer pair 3

Other 1

Microarray probesets 3

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MGI:1917718

Summaries

All 44

Developmental Gene Expression 6

Diseases 1

Gene Ontology 6

Phenotypes 15
Earliest

J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Wfikkn2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr110140	Chr11:94133765-94133782 (-)	3,057 bp
Tssr110139	Chr11:94133731-94133755 (-)	3,088 bp
Tssr110138	Chr11:94133559-94133585 (-)	3,259 bp
Tssr110137	Chr11:94133527-94133555 (-)	3,290 bp
Tssr110136	Chr11:94133482-94133490 (-)	3,345 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24