Hk3 MGI Mouse Gene Detail - MGI:2670962

Symbol

Hk3
Name

hexokinase 3

Feature Type

protein coding gene
IDs

MGI:2670962
NCBI Gene: 212032
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr13:55153798-55169198 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 29.80 cM
Mapping Data

1 experiment

SNPs within 2kb

464 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2670962	protein coding gene	Chr13:55153798-55169233 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020583	protein coding gene	Chr13:54440621-54455964 (-)
A/J	MGP_AJ_G0020537	protein coding gene	Chr13:52434340-52449773 (-)
AKR/J	MGP_AKRJ_G0020515	protein coding gene	Chr13:53979358-53994708 (-)
BALB/cJ	MGP_BALBcJ_G0020533	protein coding gene	Chr13:52675142-52690502 (-)
C3H/HeJ	MGP_C3HHeJ_G0020332	protein coding gene	Chr13:53801536-53816916 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020967	protein coding gene	Chr13:56091505-56122516 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018549	protein coding gene	Chr13:50420646-50436101 (-)
CAST/EiJ	MGP_CASTEiJ_G0019846	protein coding gene	Chr13:53892939-53908604 (-)
CBA/J	MGP_CBAJ_G0020292	protein coding gene	Chr13:58234160-58249727 (-)
DBA/2J	MGP_DBA2J_G0020415	protein coding gene	Chr13:52001273-52016629 (-)
FVB/NJ	MGP_FVBNJ_G0020394	protein coding gene	Chr13:51465750-51481097 (-)
LP/J	MGP_LPJ_G0020491	protein coding gene	Chr13:54715986-54731319 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020423	protein coding gene	Chr13:57736958-57752305 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021010	protein coding gene	Chr13:53569285-53584628 (-)
PWK/PhJ	MGP_PWKPhJ_G0019602	protein coding gene	Chr13:51994138-52009989 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019429	protein coding gene	Chr13:52498987-52514423 (-)
WSB/EiJ	MGP_WSBEiJ_G0019908	protein coding gene	Chr13:53913051-53928400 (-)

Human Ortholog

HK3, hexokinase 3

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HK3, hexokinase 3
Synonyms

HKIII, HXK3
Links

HGNC:4925

NCBI Gene ID: 3101

neXtProt AC: NX_P52790

UniProt: P52790
Chr Location

5q35.2; chr5:176880869-176899346 (-) GRCh38

MGI Vertebrate Homology

Hk3 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: HK3
Gene Tree

Hk3

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References

1 with disease annotations

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

4
Targeted

1
Genomic Mutations

2 involving Hk3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

45 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

31
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

834
Tissues

101
cDNA Data

21
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

78
RefSeq

11
UniProt

11
CCDS

CCDS26538.1, CCDS56883.1, CCDS56884.1

Ensembl

ENSMUSG00000025877 (Evidence)
NCBI Gene

212032

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025877	Ensembl Gene Model \| MGI Sequence Detail	15401	C57BL/6J	± kb
transcript	ENSMUST00000052949	Ensembl \| MGI Sequence Detail	3219	Not Applicable
polypeptide	ENSMUSP00000051215	Ensembl \| MGI Sequence Detail	922	Not Applicable

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UniProt

11 Sequences
Protein Ontology

PR:000008610 hexokinase-3

(term hierarchy)
EC

2.7.1.-, 2.7.1.1
InterPro Domains

IPR043129 ATPase, nucleotide binding domain

IPR001312 Hexokinase

IPR019807 Hexokinase, binding site

IPR022673 Hexokinase, C-terminal

IPR022672 Hexokinase, N-terminal

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All nucleic 23

cDNA 21

Primer pair 2

Microarray probesets 3

Summaries

All 39

Developmental Gene Expression 4

Diseases 1

Gene Ontology 9

Phenotypes 9
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Hk3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr122673	Chr13:55170584-55170596 (-)	-1,392 bp
Tssr122672	Chr13:55169357-55169369 (-)	-165 bp
Tssr122671	Chr13:55169299-55169306 (-)	-105 bp
Tssr122670	Chr13:55169285-55169298 (-)	-94 bp
Tssr122669	Chr13:55169100-55169116 (-)	90 bp
Tssr122668	Chr13:55169009-55169052 (-)	167 bp
Tssr122667	Chr13:55167939-55167948 (-)	1,254 bp
Tssr122666	Chr13:55166943-55166953 (-)	2,250 bp
Tssr122665	Chr13:55166360-55166374 (-)	2,831 bp
Tssr122664	Chr13:55166344-55166358 (-)	2,847 bp
Tssr122663	Chr13:55166182-55166195 (-)	3,009 bp
Tssr122662	Chr13:55166010-55166021 (-)	3,182 bp
Tssr122661	Chr13:55165910-55165921 (-)	3,282 bp
Tssr122660	Chr13:55154732-55154741 (-)	14,461 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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