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Tent5a Gene Detail
Summary
  • Symbol
    Tent5a
  • Name
    terminal nucleotidyltransferase 5A
  • Synonyms
    BAP014, D930050G01Rik, Fam46a
  • Feature Type
    protein coding gene
  • IDs
    MGI:2670964
    NCBI Gene: 212943
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:85202492-85209203 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 46.04 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    170 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2670964
 protein coding gene Chr9:85202492-85209401 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035091
 protein coding gene Chr9:86077830-86084731 (-)
A/J MGP_AJ_G0035072
 protein coding gene Chr9:83087125-83094026 (-)
AKR/J MGP_AKRJ_G0035000
 protein coding gene Chr9:85050779-85057680 (-)
BALB/cJ MGP_BALBcJ_G0035060
 protein coding gene Chr9:82734068-82740968 (-)
C3H/HeJ MGP_C3HHeJ_G0034772
 protein coding gene Chr9:85531035-85537935 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035584
 protein coding gene Chr9:88408992-88415895 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032491
 protein coding gene Chr9:81908124-81915022 (-)
CAST/EiJ MGP_CASTEiJ_G0034090
 protein coding gene Chr9:85949255-86003151 (-)
CBA/J MGP_CBAJ_G0034745
 protein coding gene Chr9:91605760-91612667 (-)
DBA/2J MGP_DBA2J_G0034903
 protein coding gene Chr9:82663178-82670082 (-)
FVB/NJ MGP_FVBNJ_G0034846
 protein coding gene Chr9:81776549-81783449 (-)
LP/J MGP_LPJ_G0034984
 protein coding gene Chr9:86294880-86301781 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034888
 protein coding gene Chr9:93173379-93180279 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035604
 protein coding gene Chr9:85185801-85192701 (-)
PWK/PhJ MGP_PWKPhJ_G0033794
 protein coding gene Chr9:82799956-82848522 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033630
 protein coding gene Chr9:85327431-85376990 (-)
WSB/EiJ MGP_WSBEiJ_G0034207
 protein coding gene Chr9:85206470-85214451 (-)



Homology
more
  • Human Ortholog
    TENT5A, terminal nucleotidyltransferase 5A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TENT5A, terminal nucleotidyltransferase 5A
  • Synonyms
    C6orf37, FAM46A, OI18, XTP11
  • Links
    NCBI Gene ID: 55603
    neXtProt AC: NX_Q96IP4
    UniProt: Q96IP4

  • Chr Location
    6q14.1; chr6:81491439-81752774 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human TENT5A associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    65 phenotypes from 2 alleles in 2 genetic backgrounds
    3 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for an ENU-induced allele show partial lethality, high alkaline phosphatase (ALP) activity, short stature, and limb, long bone, rib, pelvis and skull anomalies, with absent trabeculae and reduced cortical thickness in long bones. Heterozygotes show high ALP activity but no other defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    803
  • Tissues
    27
  • cDNA Data
    61
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 212943 NCBI Gene Model | MGI Sequence Detail 6712 C57BL/6J ±  kb
    transcript NM_001160378 RefSeq | MGI Sequence Detail 5479 C57BL/6  
    polypeptide D3Z5S8 UniProt | EBI | MGI Sequence Detail 447 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 65
      Genomic 1
      cDNA 61
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2443837, MGI:5425501, MGI:6155752
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 4
      Gene Ontology 5
      Phenotypes 10
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory