Fez1 MGI Mouse Gene Detail - MGI:2670976 - fasciculation and elongation protein zeta 1

Symbol

Fez1
Name

fasciculation and elongation protein zeta 1
Synonyms

MGC:19293, UNC-76, UNC76, zygin I

Feature Type

protein coding gene
IDs

MGI:2670976
NCBI Gene: 235180
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr9:36733160-36790220 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 20.69 cM
Mapping Data

2 experiments

SNPs within 2kb

1510 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2670976	protein coding gene	Chr9:36732694-36790220 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034557	protein coding gene	Chr9:34741278-34806032 (+)
A/J	MGP_AJ_G0034536	protein coding gene	Chr9:33845037-33904676 (+)
AKR/J	MGP_AKRJ_G0034463	protein coding gene	Chr9:34591418-34651799 (+)
BALB/cJ	MGP_BALBcJ_G0034527	protein coding gene	Chr9:33684070-33743627 (+)
C3H/HeJ	MGP_C3HHeJ_G0034240	protein coding gene	Chr9:35019143-35081440 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035049	protein coding gene	Chr9:35875733-35940518 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031975	protein coding gene	Chr9:32973953-33030990 (+)
CAST/EiJ	MGP_CASTEiJ_G0033561	protein coding gene	Chr9:34699963-34826071 (+)
CBA/J	MGP_CBAJ_G0034213	protein coding gene	Chr9:37114751-37183403 (+)
DBA/2J	MGP_DBA2J_G0034371	protein coding gene	Chr9:33894147-33953928 (+)
FVB/NJ	MGP_FVBNJ_G0034312	protein coding gene	Chr9:33152366-33209792 (+)
LP/J	MGP_LPJ_G0034456	protein coding gene	Chr9:34982038-35042899 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034358	protein coding gene	Chr9:38761666-38822216 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035068	protein coding gene	Chr9:34523476-34585762 (+)
PWK/PhJ	MGP_PWKPhJ_G0033267	protein coding gene	Chr9:33801720-33861773 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033101	protein coding gene	Chr9:34730853-34849213 (+)
WSB/EiJ	MGP_WSBEiJ_G0033677	protein coding gene	Chr9:34326804-34389011 (+)

Human Ortholog

FEZ1, fasciculation and elongation protein zeta 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FEZ1, fasciculation and elongation protein zeta 1
Synonyms

UNC-76
Links

HGNC:3659

NCBI Gene ID: 9638

neXtProt AC: NX_Q99689

UniProt: Q99689
Chr Location

11q24.2; chr11:125442881-125592568 (-) GRCh38

MGI Vertebrate Homology

Fez1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FEZ1
Gene Tree

Fez1

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Phenotype Summary

10 phenotypes from 1 allele in 2 genetic backgrounds
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

44
Endonuclease-mediated

1
Gene trapped

41
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit hyperactivity and increased sensitivity to methamphetamine.

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All GO Annotations

33
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

788
Tissues

47
cDNA Data

53
Literature Summary

5

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fez1

ZFIN fez1

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All Sequences

73
RefSeq

18
UniProt

8
CCDS

CCDS40581.1

Ensembl

ENSMUSG00000032118 (Evidence)
NCBI Gene

235180

			Length	Strain/Species	Flank
genomic	ENSMUSG00000032118	Ensembl Gene Model \| MGI Sequence Detail	57061	C57BL/6J	± kb
transcript	ENSMUST00000034630	Ensembl \| MGI Sequence Detail	1794	Not Applicable
polypeptide	ENSMUSP00000034630	Ensembl \| MGI Sequence Detail	392	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000007466 fasciculation and elongation protein zeta-1

(term hierarchy)
InterPro Domains

IPR011680 Fasciculation and elongation protein zeta, FEZ

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All nucleic 56

cDNA 54

Primer pair 1

Other 1

Microarray probesets 2

Summaries

All 39

Developmental Gene Expression 5

Gene Ontology 7

Phenotypes 7
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Fez1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr84372	Chr9:36743996-36744151 (+)	10,914 bp
Tssr84373	Chr9:36761673-36761688 (+)	28,521 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24