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Klhdc1 Gene Detail
Summary
  • Symbol
    Klhdc1
  • Name
    kelch domain containing 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2672853
    NCBI Gene: 271005
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:69287950-69331406 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 28.74 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1302 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2672853
 protein coding gene Chr12:69274529-69331420 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019792
 protein coding gene Chr12:68907616-68959189 (+)
A/J MGP_AJ_G0019750
 protein coding gene Chr12:66356558-66401065 (+)
AKR/J MGP_AKRJ_G0019726
 protein coding gene Chr12:68340413-68384218 (+)
BALB/cJ MGP_BALBcJ_G0019730
 protein coding gene Chr12:66820036-66864780 (+)
C3H/HeJ MGP_C3HHeJ_G0019536
 protein coding gene Chr12:68806097-68853457 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020182
 protein coding gene Chr12:71100168-71148914 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017802
 protein coding gene Chr12:63901239-63945882 (+)
CAST/EiJ MGP_CASTEiJ_G0019087
 protein coding gene Chr12:63557222-63601686 (+)
CBA/J MGP_CBAJ_G0019505
 protein coding gene Chr12:73730326-73785643 (+)
DBA/2J MGP_DBA2J_G0019621
 protein coding gene Chr12:66269993-66312894 (+)
FVB/NJ MGP_FVBNJ_G0019608
 protein coding gene Chr12:65169187-65211792 (+)
LP/J MGP_LPJ_G0019693
 protein coding gene Chr12:68872172-68917882 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019647
 protein coding gene Chr12:77079968-77128009 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020217
 protein coding gene Chr12:67813601-67858264 (+)
PWK/PhJ MGP_PWKPhJ_G0018852
 protein coding gene Chr12:60533217-60577024 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018647
 protein coding gene Chr12:62205705-62252097 (+)
WSB/EiJ MGP_WSBEiJ_G0019138
 protein coding gene Chr12:68423481-68473555 (+)



Homology
more
  • Human Ortholog
    KLHDC1, kelch domain containing 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KLHDC1, kelch domain containing 1
  • Synonyms
    MST025
  • Links
    NCBI Gene ID: 122773
    neXtProt AC: NX_Q8N7A1
    UniProt: Q8N7A1

  • Chr Location
    14q21.3; chr14:49693105-49753150 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    21
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000051890 Ensembl Gene Model | MGI Sequence Detail 43457 C57BL/6J ±  kb
transcript ENSMUST00000063445 Ensembl | MGI Sequence Detail 2620 Not Applicable  
polypeptide ENSMUSP00000068046 Ensembl | MGI Sequence Detail 406 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    cDNA 21

    Microarray probesets 1
References
more
  • Summaries
    All 26
    Gene Ontology 5
    Phenotypes 7
  • Earliest
    J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory