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Tcfl5 Gene Detail
Summary
  • Symbol
    Tcfl5
  • Name
    transcription factor-like 5 (basic helix-loop-helix)
  • Synonyms
    FIG beta, Figlb
  • Feature Type
    protein coding gene
  • IDs
    MGI:2672878
    NCBI Gene: 277353
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:180263749-180284501 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 103.16 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    370 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2672878
 protein coding gene Chr2:180263749-180284540 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026999
 protein coding gene Chr2:187154627-187175241 (-)
A/J MGP_AJ_G0026965
 protein coding gene Chr2:179464670-179486167 (-)
AKR/J MGP_AKRJ_G0026935
 protein coding gene Chr2:184846398-184867318 (-)
BALB/cJ MGP_BALBcJ_G0026974
 protein coding gene Chr2:179928706-179949337 (-)
C3H/HeJ MGP_C3HHeJ_G0026715
 protein coding gene Chr2:185196645-185218205 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027420
 protein coding gene Chr2:192556641-192577330 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024785
 protein coding gene Chr2:170155611-170176565 (-)
CAST/EiJ MGP_CASTEiJ_G0026174
 protein coding gene Chr2:183437454-183459098 (-)
CBA/J MGP_CBAJ_G0026692
 protein coding gene Chr2:199558230-199578828 (-)
DBA/2J MGP_DBA2J_G0026830
 protein coding gene Chr2:178562241-178583142 (-)
FVB/NJ MGP_FVBNJ_G0026796
 protein coding gene Chr2:177177653-177198295 (-)
LP/J MGP_LPJ_G0026931
 protein coding gene Chr2:187164363-187185182 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026815
 protein coding gene Chr2:202156464-202177042 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027479
 protein coding gene Chr2:184800902-184822869 (-)
PWK/PhJ MGP_PWKPhJ_G0025910
 protein coding gene Chr2:176074181-176095074 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025710
 protein coding gene Chr2:181297806-181320330 (-)
WSB/EiJ MGP_WSBEiJ_G0026246
 protein coding gene Chr2:185785709-185807293 (-)



Homology
more
  • Human Ortholog
    TCFL5, transcription factor like 5
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TCFL5, transcription factor like 5
  • Synonyms
    bHLHe82, CHA, E2BP-1, Figlb, SOSF1
  • Links
    NCBI Gene ID: 10732
    neXtProt AC: NX_Q9UL49
    UniProt: Q9UL49

  • Chr Location
    20q13.33; chr20:62841005-62861822 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit male sterility associated with small testis size, azoospermia, multinucleated giant male germ cells, arrest of male meiosis in a diplotene like stage, and increased male germ cell apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    858
  • Tissues
    149
  • cDNA Data
    11
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038932 Ensembl Gene Model | MGI Sequence Detail 20753 C57BL/6J ±  kb
    transcript ENSMUST00000037877 Ensembl | MGI Sequence Detail 2225 Not Applicable  
    polypeptide ENSMUSP00000040611 Ensembl | MGI Sequence Detail 489 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR036638 Helix-loop-helix DNA-binding domain superfamily
      IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
      IPR039583 Transcription factor-like 5/SOLH1/2
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 11
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2139262
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 6
      Gene Ontology 3
      Phenotypes 10
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:344789 Cecchini K, et al., The transcription factor TCFL5 responds to A-MYB to elaborate the male meiotic program in mice. Reproduction. 2023 Feb 1;165(2):183-196
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory